DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brp and Erc2

DIOPT Version :9

Sequence 1:	NP_001246228.1	Gene:	brp / 35977	FlyBaseID:	FBgn0259246	Length:	2238	Species:	Drosophila melanogaster
Sequence 2:	XP_017455492.2	Gene:	Erc2 / 259269	RGDID:	708372	Length:	1136	Species:	Rattus norvegicus

Alignment Length:	1443	Identity:	302/1443 - (20%)
Similarity:	510/1443 - (35%)	Gaps:	598/1443 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SPGRVRRLQELPTV-DRSPSRDYGAPRGSPLAM-------------GSPYYRDMD---EPTSPAG 63
            ||.|..||...|.: .|..|...|...|..|:|             |..|..|.:   ..|.|.|
  Rat    14 SPSRSPRLPRSPRLGHRRTSSGGGGGTGKTLSMENIQSLNAAYATSGPMYLSDHEGVASTTYPKG 78

  Fly    64 A---GHHRSRS---------ASRPPMAHA-MDYPRTRYQSLDRGGL--VDPHDREFIP--IREPR 111
            .   |...:|:         .|.|.:|.| :.:......:...|||  ...|....:|  :|:.|
  Rat    79 TMTLGRATNRAVYGGRVTAMGSSPNIASAGLSHTDVLSYTDQHGGLGGSSHHHHHQVPSMLRQVR 143

  Fly   112 DRSRDRSLERGLYLEDELYGRSARQSPSAMGGYNTGMGPTSDRAYLGDLQHQNTDLQRELGNLKR 176
            |.:                                          :.|||.|..:||||...|::
  Rat   144 DST------------------------------------------MLDLQAQLKELQRENDLLRK 166

  Fly   177 ELELTNQKLGSSMHSIKTFWSPELKKERALRKEESAKYSLINDQLKLLSTENQ-------KQAML 234
            ||::.:.||||||:||||||||||||||.|||||:|:.|::.:|:::...|||       |...|
  Rat   167 ELDIKDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLKEQMRVSHEENQLLDARRTKHLQL 231

  Fly   235 -VRQLEEELRLRMRQPNLEMQQQ-----------------MEAIYAENDHLQREISILRETIKDL 281
             ::.|::|||.: |..|..:||:                 ...:.||:|...:|:.:||:|::::
  Rat   232 TIQALQDELRTQ-RDLNHLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEM 295

  Fly   282 ECRVETQKQTLIARDESIKKLLEMLQAKGMGKEEERQMFQQMQAMAQKQMYNNYTGASGSSPPLP 346
            |.|:|||||||.||||||||||||||:||:
  Rat   296 ELRIETQKQTLNARDESIKKLLEMLQSKGL----------------------------------- 325

  Fly   347 DIIGQYYGPGSLGPGPLSYGSGNGYGPPGYDLYGPSTSTAAGGYGLYDPQIYGPCQQTSPIRRRR 411
                                              ||.|.                 :....|.||
  Rat   326 ----------------------------------PSKSL-----------------EDDNERTRR 339

  Fly   412 YSIAGLPSATMYNDVYGYPAPPLQQTSSSNIVNLLNEAHKSISRSSQILNLTNQARQLGQLVTTP 476
              :|...|...:.:|.      |.|....|| :|..|.|    |.||:
  Rat   340 --MAEAESQVSHLEVI------LDQKEKENI-HLREELH----RRSQL----------------- 374

  Fly   477 LGGGGVGMGLGRVVSSYPTLHPGDTSPPYLNDNLMQMSTSFSSQPNMYFQPQAQVQQVLPTQLTA 541
                                                             ||:....:.|.|.:..
  Rat   375 -------------------------------------------------QPEPAKTKALQTVIEM 390

  Fly   542 AQSAAAAAARLRPAYSVTNLVSSYPTTTAAGYGCKYGGYGNPYQSDLGYGNPLAPFQQRQLMAHQ 606
            ..:..|:..|
  Rat   391 KDTKIASLER------------------------------------------------------- 400

  Fly   607 SLHASNPAISQYYQNQGAATGTGASAAALAYNLQQQFAGTQHYGGGSQGPPLGHSHIQASVQQQM 671

  Rat   401 ----------------------------------------------------------------- 400

  Fly   672 HPQYQYHVHQHQNHLQTHPLAALANTSGPFGGTLASSARDYVDGLHHAAHSHTHPHSHPHHSSHH 736
                  ::...::.:|......:.||.
  Rat   401 ------NIRDLEDEIQMLKANGVLNTE-------------------------------------- 421

  Fly   737 SHHTAYPHSHSHHQQQQPHQAHHHHHLPYSKLDLDYPKLPQEHKRQLDEFRLEIQRRDQEILAMA 801
                   ......:|.:.:::|       ||.          .|.::|:.:.|:.:::.|:||:.
  Rat   422 -------DREEEIKQIEVYKSH-------SKF----------MKTKIDQLKQELSKKESELLALQ 462

  Fly   802 AKMKTLEEQHQDYQRHIAVLKESLCAKEEHYNMLQTDVEEMRARLEEKNRLIEKKTQGTLQTVQE 866
            .|::||..|:.|.::||.||||||.|||:...:|||:|:.:|.|||||...:.|||:......:|
  Rat   463 TKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEE 527

  Fly   867 RNRLTSELTELKDHMDIKDRKISVLQRKIENLEDLLKEKDNQVDMARARLSAMQAHHSSSEGALT 931
            :..|..|:.::||.:::|:|||:|||:|||||::.|::||.|:...:.|:.::|...|:::.||.
  Rat   528 KGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALA 592

  Fly   932 SLEEAIGDKEKQMAQLRDQRDRAEHEKQEERDLHEREVADYKIKLRAAESEVEKLQTRLERAVTE 996
            :||||:.:||:.:.:|::||:|.:.|:.||.:...:|..|.|.|:.|.::|           :||
  Rat   593 TLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAE-----------LTE 646

  Fly   997 RERLEIKLEASQSELGKSKAELEKATCEMGRSSADWESTKQRIARLELENERLKHDLERSQNVQK 1061
            :|...|.|:...|.|         |:..:.|.|        ::..||:..|:.|
  Rat   647 KESSLIDLKEHASSL---------ASAGLKRDS--------KLKSLEIAIEQKK----------- 683

  Fly  1062 LMFETGKISTTFGRTTMTTSQELDRAQERADKASAELRRTQAEL---------------RVTQSD 1111
                                       |..:|..|:|::...:|               |:....
  Rat   684 ---------------------------EECNKLEAQLKKQAEQLFNQMYNPAHNIEDDSRMNPEF 721

  Fly  1112 AERARE---EAAALQEKLEKSQGEVYRLKAKLENAQGEQESLRQELEKAQSGVSRIHADRDRAFS 1173
            |:|.::   ||:..:::..|:|.||.||...|:..:.|:....:::.:.:|...|...|:::..:
  Rat   722 ADRLKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTLRHMKDQNKKVA 786

  Fly  1174 ------EVEKIK-----EEMERTQATL--GKSQLQHEKLQNSLDKAQNEVDHLQDKLDKACTENR 1225
                  ::||.|     ||:.|.:.::  ....||.|:|.|:|:|.:.|:|..:.:|    ...:
  Rat   787 NLKHNQQLEKKKNAQLLEEVRRREDSMVDNSQHLQIEELMNALEKTRQELDATKARL----ASTQ 847

  Fly  1226 RLVLEKEKLTYDYDNLQSQLDKALGQAARMQKERETLSLD--------TDRIREKLEKTQVQLGR 1282
            :.:.|||.   ...||:.:..|.|.:...|::|....::.        .:....|.:|||.::..
  Rat   848 QSLAEKEA---HLANLRMERRKQLEEILEMKQEALLAAISEKDANIALLELSASKKKKTQEEVMA 909

  Fly  1283 IQKERDQFSDELE---------------------------TLKERSESAQTLLMKAARDREAMQT 1320
            :::|:|:...:|:                           |.|....|....:    ..|...|.
  Rat   910 LKREKDRLVHQLKQQVYRPRKQPPCSNIPCTCDAGYSPDFTAKYHGSSYDAYM----GQRSQTQN 970

  Fly  1321 DLEVLKERYEKSH 1333
            .::::.:.|:..|
  Rat   971 RMKLMADNYDDDH 983

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brp	NP_001246228.1	KRTAP	332..401	CDD:256601	3/68 (4%)
		Myosin_tail_1	789..1824	CDD:279860	152/611 (25%)
		SMC_prok_B	1509..>2215	CDD:274008
		Bud13	2091..>2157	CDD:286779
Erc2	XP_017455492.2	Cast	151..924	CDD:401982	261/1199 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	350	1.000	Inparanoid score	I2209
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002038
OrthoInspector	1	1.000	-	-		otm45885
orthoMCL	1	0.900	-	-		OOG6_104556
Panther	1	1.100	-	-	LDO	PTHR18861
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1708
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.960