DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brp and ERC1

DIOPT Version :9

Sequence 1:	NP_001246228.1	Gene:	brp / 35977	FlyBaseID:	FBgn0259246	Length:	2238	Species:	Drosophila melanogaster
Sequence 2:	XP_016874541.1	Gene:	ERC1 / 23085	HGNCID:	17072	Length:	1141	Species:	Homo sapiens

Alignment Length:	1655	Identity:	349/1655 - (21%)
Similarity:	602/1655 - (36%)	Gaps:	668/1655 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 RSPGRVRRLQELPTVDRSPSRDYGAPRGSPLAMGSPYYRDMDEPTSPAGAGHHRSRSASRPPMAH 79
            :||||..||...|.:....:...|...||.:..||.....|:...|...|      .|:..||
Human    16 QSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAA------YATSGPM-- 72

  Fly    80 AMDYPRTRYQSLDRGGLVDPHDREFIPIREPRDRSRDRSLERGLYLEDELYGRSARQSP-----S 139
                    |.|          |.|.:....|:...              ..|||..:.|     :
Human    73 --------YLS----------DHENVGSETPKSTM--------------TLGRSGGRLPYGVRMT 105

  Fly   140 AMGGYN--TGMGPTSDRAYLG--------------------------DLQHQNTDLQRELGNLKR 176
            |||...  ...|..||....|                          |||.|..::.||...|::
Human   106 AMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRK 170

  Fly   177 ELELTNQKLGSSMHSIKTFWSPELKKERALRKEESAKYSLINDQLKLLSTENQKQAMLVRQLEEE 241
            ::|:...||.|||:||||||||||||||||||:|::|.::..:|.:::..|||...|.::.|::|
Human   171 DVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDE 235

  Fly   242 LRLRMRQPNLEMQQ-----------------QMEAIYAENDHLQREISILRETIKDLECRVETQK 289
            ||:: |..|...||                 ..:.::||::...:|:.:||:|::::|.|:||||
Human   236 LRIQ-RDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQK 299

  Fly   290 QTLIARDESIKKLLEMLQAKGMGKEEERQMFQQMQAMAQKQMYNNYTGASGSSPPLPDIIGQYYG 354
            |||.||||||||||||||:||:..:...:..::.:.:|:.:|:.::
Human   300 QTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHH------------------- 345

  Fly   355 PGSLGPGPLSYGSGNGYGPPGYDLYGPSTSTAAGGYGLYDPQIYGPCQQTSPIRRRRYSIAGLPS 419
                                                                          |.|
Human   346 --------------------------------------------------------------LES 348

  Fly   420 ATMYNDVYGYPAPPLQQTSSSNIVNLLNEAHKSISRSSQILNLTNQARQLGQLVTTPLGGGGVGM 484
            .             |:|....|  ::|.|
Human   349 L-------------LEQKEKEN--SMLRE------------------------------------ 362

  Fly   485 GLGRVVSSYPTLHPGDTSPPYLNDNLMQMSTSFSSQPNMYFQPQAQVQQVLPTQLTAAQSAAAAA 549
                                       :|...|.:.|:                          :
Human   363 ---------------------------EMHRRFENAPD--------------------------S 374

  Fly   550 ARLRPAYSVTNLVSSYPTTTAAGYGCKYGGYGNPYQSDLGYGNPLAPFQQRQLMAHQSLHASNPA 614
            |:.:...:|..:..|..::...|.                          |.|.....:..||.|
Human   375 AKTKALQTVIEMKDSKISSMERGL--------------------------RDLEEEIQMLKSNGA 413

  Fly   615 ISQYYQNQGAATGTGASAAALAYNLQQQFAGTQHYGGGSQGPPLGHSHIQASVQQQMHPQYQYHV 679
            :                                                  |.:::.....|..|
Human   414 L--------------------------------------------------STEEREEEMKQMEV 428

  Fly   680 HQHQNHLQTHPLAALANTSGPFGGTLASSARDYVDGLHHAAHSHTHPHSHPHHSSHHSHHTAYPH 744
            ::
Human   429 YR--------------------------------------------------------------- 430

  Fly   745 SHSHHQQQQPHQAHHHHHLPYSKLDLDYPKLP------QEHKRQLDEFRLEIQRRDQEILAMAAK 803
            |||...:.:..|....    .|..:..:.:|.      |.....:.:.:.|:.|:|.|:||:..|
Human   431 SHSKFMKNKVEQLKEE----LSSKEAQWEELKKKAAGLQAEVFAIGQVKQELSRKDTELLALQTK 491

  Fly   804 MKTLEEQHQDYQRHIAVLKESLCAKEEHYNMLQTDVEEMRARLEEKNRLIEKKTQGTLQTVQERN 868
            ::||..|..|.::||.||||||.|||:...:|||:|:.:|.|||||..::.|||:......:|:.
Human   492 LETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKG 556

  Fly   869 RLTSELTELKDHMDIKDRKISVLQRKIENLEDLLKEKDNQVDMARARLSAMQAHHSSSEGALTSL 933
            ....|:.:|||.:|:|:||::|||:|||||::.|::|:.|:...:.|:.::||..::::.|||:|
Human   557 TQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTL 621

  Fly   934 EEAIGDKEKQMAQLRDQRDRAEHEKQEERDLHEREVADYKIKLRAAESEVEKLQTRL----ERAV 994
            |||:.:||:.:.:|::||||.|.|||||.|.:::::.|.|.|:...:.::.:.:..|    |.|.
Human   622 EEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHAS 686

  Fly   995 ----------TERERLEIKLEASQSELGKSKAELEKATCEMGRSSADWESTKQRIARLELENERL 1049
                      :..:.|||.||..:.|..|.:::|:||          .|:..:..|..|: ::|:
Human   687 SLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA----------HEAALEARASPEM-SDRI 740

  Fly  1050 KHDLERSQNVQKLMFETGKISTTFGRTTMTTSQELDRAQERADKASAELRR---TQAELRVTQSD 1111
            :| |||                           |:.|.::.:.||.||:.|   ...|:...::|
Human   741 QH-LER---------------------------EITRYKDESSKAQAEVDRLLEILKEVENEKND 777

  Fly  1112 AERAREEAAALQEKLEKSQG-EVYRLKAKLENAQGEQESLRQELEKAQSGVSRIHADRDRAFSEV 1175
            .::...|..:|..:..|.|. :|..||.|            :::||.:|.
Human   778 KDKKIAELESLTSRQVKDQNKKVANLKHK------------EQVEKKKSA--------------- 815

  Fly  1176 EKIKEEMERTQATLGKSQLQHEKLQNSLDKAQNEVDHLQDKLDKA--CTENRRLVLEKEKLTYDY 1238
             ::.||..|.:..|..|.   ::||:||.|..:.::.|::.|.::  .|..|.:||.:|
Human   816 -QMLEEARRREDNLNDSS---QQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQE------ 870

  Fly  1239 DNLQSQLDKALGQAARMQKERETLSLDTDRIREKLEKTQ------VQLGRIQKERDQFSDELETL 1297
                        ::||...|::.|       ||.|.:|.      .::..:....::...|||::
Human   871 ------------ESARTNAEKQLL-------REILHETSYLNFKWFKVEELLMAMEKVKQELESM 916

  Fly  1298 KERSESAQTLLMKAARDREAMQTDLEVLKERYEKSHAIQQKLQMERDDAVTEVEILKEKLDKALY 1362
            |.:..|.|    ::..::|...|:|     |.|:...:::.|:|:::               ||.
Human   917 KAKLSSTQ----QSLAEKETHLTNL-----RAERRKHLEEVLEMKQE---------------ALL 957

  Fly  1363 ASQKLIDEKDTSNKEFEKMLEKYDRAQNEIYRLQSRCDTAEADRARLEVEAERSGLAASKAREDL 1427
            |:   |.|||                               |:.|.||       |::||
Human   958 AA---ISEKD-------------------------------ANIALLE-------LSSSK----- 976

  Fly  1428 RKLQDESTRLQEACDRAALQLSRAKECEDNARSELEHSRDRFDKLQTDIRRAQGEKEHFQSELER 1492
            :|.|:|...|:...||...||.             :.:::|. ||..|    ..|.:||:|
Human   977 KKTQEEVAALKREKDRLVQQLK-------------QQTQNRM-KLMAD----NYEDDHFKS---- 1019

  Fly  1493 VTYELERAHAAQTKASASVEAAKEEAAHYAVELEKMRDR------------YEKSQVELRKLQDT 1545
                   :|:.||....|    .::.....:||::.|.:            :::..:.||.|...
Human  1020 -------SHSNQTNHKPS----PDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPP 1073

  Fly  1546 DTFGRETRRLKEENE-------RLREKLDK 1568
            .::..:..:...|||       :|:::|:|
Human  1074 ASYNLDDDQAAWENELQKMTRGQLQDELEK 1103

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brp	NP_001246228.1	KRTAP	332..401	CDD:256601	0/68 (0%)
		Myosin_tail_1	789..1824	CDD:279860	207/825 (25%)
		SMC_prok_B	1509..>2215	CDD:274008	13/79 (16%)
		Bud13	2091..>2157	CDD:286779
ERC1	XP_016874541.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	186	1.000	Domainoid score	I3375
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	371	1.000	Inparanoid score	I2131
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002038
OrthoInspector	1	1.000	-	-		otm41752
orthoMCL	1	0.900	-	-		OOG6_104556
Panther	1	1.100	-	-	O	PTHR18861
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3525
SonicParanoid	1	1.000	-	-		X1708
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.990