DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brp and elks-1

DIOPT Version :9

Sequence 1:	NP_001246228.1	Gene:	brp / 35977	FlyBaseID:	FBgn0259246	Length:	2238	Species:	Drosophila melanogaster
Sequence 2:	NP_500329.1	Gene:	elks-1 / 177102	WormBaseID:	WBGene00018330	Length:	836	Species:	Caenorhabditis elegans

Alignment Length:	1021	Identity:	197/1021 - (19%)
Similarity:	367/1021 - (35%)	Gaps:	304/1021 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   358 LGPGPLSYGS------GNGYGPPGYDLYGPSTSTAAGGYGLYDPQIYGPCQQTSPIRRRRYSIAG 416
            :.|||..|.|      .:|..|..|....|.||.:|.              ...|::|:..|:.|
Worm     1 MAPGPAPYSSRTSVMNSSGRNPMNYPSVPPHTSISAA--------------SRRPLQRQHRSMDG 51

  Fly   417 LPSATMYNDVYGY-----PAP--PLQQTS------SSNIVNLLNEAHKSISRSSQILNLTNQA-- 466
            |.....|.|...|     |:|  ||.|.|      |::..:.....|.:..:..|.|.|:|..
Worm    52 LGVLDAYKDSLDYDMMLQPSPPKPLHQPSYLPLEISTSQHHHPPHHHPTQFQRGQSLALSNPIPT 116

  Fly   467 -----RQLGQLVTTPL--------------GGGGVGMGLGRVVSSYPTLHPGDTSPPYLNDNLMQ 512
                 :....:.||.:              .|.|.|:.:.|........:  ||....||..:..
Worm   117 QNAFWQHNNSMATTSVQDYDLMQPGISRIPTGTGSGLNIAREYEQLKVEY--DTMMEKLNQTMNS 179

  Fly   513 MSTSFSSQPNMYFQPQAQVQQVLPTQLTAAQSAAAAAARLRPAYSVTNLVSSYPTTTAAGYGCKY 577
            :.|.:|.:              |..:....:..|...|:|.      .:|.|            .
Worm   180 IKTFWSPE--------------LKRERQMRRDEATRIAQLE------RMVQS------------G 212

  Fly   578 GGYGNPYQSDLGYGNPLAPFQQRQLMAHQSLHASNPAISQYYQNQGAATGTGASAAAL------A 636
            ||.||.|    |.|:..|      |.....|...:..|.|.  .....:|:|.....:      .
Worm   213 GGGGNDY----GLGSSEA------LQLRMELRERDERIRQL--TTALESGSGGMDGRIRELEDTI 265

  Fly   637 YNLQQQFAGTQHYGGGSQGPPLGHSHIQASVQQQMHPQYQYHVHQHQNHLQTHPLAALANTSGPF 701
            ..||......:.....:...|.|...|:.::::  ..:.|..:.:.:..|....:..
Worm   266 MRLQDLLTTKETQSMMASQDPSGRQAIENALRR--IDEKQARIVELEEELMRQRMGR-------- 320

  Fly   702 GGTLASSARDYVDGLHHAAHSHTHPHSHPHHSSHHSHHTAYPHSHSHHQQQQPHQAHHHHHLPYS 766
                ::..||:.|                .:.|.|...|.
Worm   321 ----SNQPRDFTD----------------KNLSGHEMATM------------------------- 340

  Fly   767 KLDLDYPKLPQEHKRQLDEFRLEIQRRDQEILAMAAKMKTLEEQHQDYQRHIAVLKESLCAKEEH 831
                         :.::|...:|:..:.||:.....:|:|.||...:.:.|:.:||:.|..:|:|
Worm   341 -------------RMKMDRSEVELAEKKQELFGCQTRMQTAEETANEMRGHLQLLKDQLTNREQH 392

  Fly   832 YNMLQTDVEEMRARLEEKNRLIEKKTQGTLQTVQERNRLTSELTELKDHMDI---KDRKISVLQR 893
            ..:||.||:.:|.:|:.||:.:|:|.:..  ...||: |:|...::.|..::   .:.|.|.|..
Worm   393 NTLLQGDVDALRQKLDSKNKQLEQKDERV--AALERD-LSSSKADVSDKGELIRQTEMKTSQLIG 454

  Fly   894 KIENLEDLLKEKDNQVDMARARLSAMQAHHSSSEGALTSLEEAIGDKEKQMAQLRDQRDR----- 953
            ::::||..::||:.::|.|:.|              |.|..:.:  |||:|.:..:|.:|
Worm   455 RVDSLETTVREKEQELDRAKIR--------------LLSHPDVV--KEKEMTEKIEQGERERQRL 503

  Fly   954 AEH----EKQEERDLHEREVADYKIKLRAAESEVEKLQTRLERAVTERERLEIKLEASQSELGKS 1014
            |||    .:..|:|..|::        :..::|:.:|:..:|....|....:|.||:...::|..
Worm   504 AEHIDQVRRNAEKDAMEQQ--------KTYQNEMTQLKATIENLQKELSDRDILLESQNEKIGDM 560

  Fly  1015 KAELEKATCEMGRSSADWESTKQRI--ARLELENERLKHDLERSQN-VQKLMFETGKISTTFGRT 1076
            ..:|.:|              |:|:  |.::...:.|:.|:|.::| |:||:    |:..:..:.
Worm   561 NRDLVQA--------------KKRLDDAMVDKGTDELRRDVEGARNEVEKLL----KMVHSLEKE 607

  Fly  1077 TMTTSQELDRAQERADKASAELRRTQAELRVTQSDAERAREEAAALQEKLEKSQGEVYRLKAKLE 1141
            .:|.:.:           ..:|:|         .|..||...:|      ..:.|.:.|    ..
Worm   608 NLTLTAQ-----------CKQLKR---------DDTPRAGTTSA------PSAPGTLTR----ST 642

  Fly  1142 NAQGEQESLRQELEKAQSGVSRIHADRDRAFSEVEKIKEEMERTQATLGKSQLQH-EKLQNSLDK 1205
            :||.......:|||:|......|.|:|:...|:                  |..| :::.:.|::
Worm   643 SAQNNMHKRIEELEEALRESVSITAEREVHLSQ------------------QKHHLQQVSSQLNE 689

  Fly  1206 AQNEVDHLQDKLDKACTENRRLVLEKEKLTYDYDNLQSQLDKALGQAARMQKERETLSLDTDRIR 1270
            |:.|:           ||.|| ..:....|.|.|    |:.:|: :..|.|...:...|..:.:.
Worm   690 ARKEI-----------TELRR-TKQNPSETGDRD----QIIRAI-ETERRQHLEQLFQLKQEALL 737

  Fly  1271 EKLEKTQVQLGRIQKERDQFSDELETLKERSESAQTLLMKAARDRE 1316
            ..:.:....|..::|.|.. .||:||::...::   |:.|..::.|
Worm   738 AAISEKDTHLALLEKSRGP-RDEIETIRRHKDA---LIRKLKQENE 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brp	NP_001246228.1	KRTAP	332..401	CDD:256601	12/48 (25%)
		Myosin_tail_1	789..1824	CDD:279860	119/544 (22%)
		SMC_prok_B	1509..>2215	CDD:274008
		Bud13	2091..>2157	CDD:286779
elks-1	NP_500329.1	Cast	154..781	CDD:287183	160/854 (19%)
elks-1	NP_500329.1	FAM76	<448..545	CDD:292665	28/120 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	89	1.000	Domainoid score	I4995
eggNOG	1	0.900	-	-		E1_KOG4809
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002038
OrthoInspector	1	1.000	-	-		oto17343
orthoMCL	1	0.900	-	-		OOG6_104556
Panther	1	1.100	-	-	LDO	PTHR18861
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3525
SonicParanoid	1	1.000	-	-		X1708
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.840