DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brp and Erc1

DIOPT Version :9

Sequence 1:	NP_001246228.1	Gene:	brp / 35977	FlyBaseID:	FBgn0259246	Length:	2238	Species:	Drosophila melanogaster
Sequence 2:	NP_444434.2	Gene:	Erc1 / 111173	MGIID:	2151013	Length:	1120	Species:	Mus musculus

Alignment Length:	1554	Identity:	328/1554 - (21%)
Similarity:	586/1554 - (37%)	Gaps:	558/1554 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 RSPGRVRRLQELPTVDRSPSRDYGAPRGSPLAMGSPYYRDMDEPTSPAGAGHHRSRSASRPPMAH 79
            :||||..||...|.:....:...|...|:.:..||.....|:...|...|      .|:..||
Mouse    16 QSPGRSPRLPRSPRLGHRRTNSTGGSSGNSVGGGSGKTLSMENIQSLNAA------YATSGPM-- 72

  Fly    80 AMDYPRTRYQSLDRGGLVDPHDREFIPIREPRDRSRDRSLERGLYLEDELYGRSARQSP-----S 139
                    |.|          |.|.:....|:...              ..|||..:.|     :
Mouse    73 --------YLS----------DHENVGAETPKSTM--------------TLGRSGGRLPYGVRMT 105

  Fly   140 AMGGYN--TGMGPTSDRAYLG--------------------------DLQHQNTDLQRELGNLKR 176
            |||...  ...|..||....|                          |||.|..::.||...|::
Mouse   106 AMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRK 170

  Fly   177 ELELTNQKLGSSMHSIKTFWSPELKKERALRKEESAKYSLINDQLKLLSTENQKQAMLVRQLEEE 241
            ::|:...||.|||:||||||||||||||||||:|::|.::..:|.:::..|||...|.::.|::|
Mouse   171 DVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDE 235

  Fly   242 LRLRMRQPNLEMQQ-----------------QMEAIYAENDHLQREISILRETIKDLECRVETQK 289
            ||:: |..|...||                 ..:.::||::...:|:.:||:|::::|.|:||||
Mouse   236 LRIQ-RDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQK 299

  Fly   290 QTLIARDESIKKLLEMLQAKGMGKEEERQMFQQMQAMAQKQMYNNYTGASGSSPPLPDIIGQYYG 354
            |||.||||||||||||||:||:..:...:..::.:.:|:.:|:.::
Mouse   300 QTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHH------------------- 345

  Fly   355 PGSLGPGPLSYGSGNGYGPPGYDLYGPSTSTAAGGYGLYDPQIYGPCQQTSPIRRRRYSIAGLPS 419
                                                                          |.|
Mouse   346 --------------------------------------------------------------LES 348

  Fly   420 ATMYNDVYGYPAPPLQQTSSSNIVNLLNEAHKSISRSSQILNLTNQARQLGQLVTTPLGGGGVGM 484
            .             |:|....|  |:|.|
Mouse   349 L-------------LEQKEKEN--NMLRE------------------------------------ 362

  Fly   485 GLGRVVSSYPTLHPGDTSPPYLNDNLMQMSTSFSSQPNMYFQPQAQVQQVLPTQLTAAQSAAAAA 549
                                       :|...|.:.|:                          :
Mouse   363 ---------------------------EMHRRFENAPD--------------------------S 374

  Fly   550 ARLRPAYSVTNLVSSYPTTTAAGYGCKYGGYGNPYQSDLGYGNPLAPFQQRQLMAHQSLHASNPA 614
            |:.:...:|..:..|..::...|.                          |.|.....:..||.|
Mouse   375 AKTKALQTVIEMKDSKISSMERGL--------------------------RDLEEEIQMLKSNGA 413

  Fly   615 ISQYYQNQGAATGTGASAAALAYNLQQQFAGTQHYGGGSQGPPLGHSHIQASVQQQMHPQYQYHV 679
            :|.                                                  :::.....|..|
Mouse   414 LSS--------------------------------------------------EEREEEMKQMEV 428

  Fly   680 HQHQNHLQTHPLAALANTSGPFGGTLASSARDYVDGLHHAAHSHTHPHSHPHHSSHHSHHTAYPH 744
            ::
Mouse   429 YR--------------------------------------------------------------- 430

  Fly   745 SHSHHQQQQPHQAHHHHHLPYSKLDLDYPKLPQEH---KRQLDEFRLEIQRRDQEILAMAAKMKT 806
            |||...:.:..|....    .|..|....:|.:..   :.::.:.:.|:.|:|.|:||:..|::|
Mouse   431 SHSKFMKNKVEQLKEE----LSSKDAQGEELKKRAAGLQSEIGQVKQELSRKDTELLALQTKLET 491

  Fly   807 LEEQHQDYQRHIAVLKESLCAKEEHYNMLQTDVEEMRARLEEKNRLIEKKTQGTLQTVQERNRLT 871
            |..|..|.::||.||||||.|||:...:|||:|:.:|.|||||..::.|||:......:|:....
Mouse   492 LTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQA 556

  Fly   872 SELTELKDHMDIKDRKISVLQRKIENLEDLLKEKDNQVDMARARLSAMQAHHSSSEGALTSLEEA 936
            .|:.:|||.:|:|:||::|||:|||||::.|::|:.|:...:.|:.::||..::::.|||:||||
Mouse   557 GEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEA 621

  Fly   937 IGDKEKQMAQLRDQRDRAEHEKQEERDLHEREVADYKIKLRAAESEVEKLQTRL----ERAV--- 994
            :.|||:.:.:|::||||.|.|||||.|.:::::.|.:.|:...:.::.:.:..|    |.|.
Mouse   622 LADKERTIERLKEQRDRDEREKQEEIDTYKKDLKDLREKVSLLQGDLSEKEASLLDIKEHASSLA 686

  Fly   995 -------TERERLEIKLEASQSELGKSKAELEK---ATCEMGRSSADWESTKQRIARLELENERL 1049
                   :..:.|||.||..:.|..|.:::|:|   ||.| .|:|.:   ...||.:||.|..|.
Mouse   687 SSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEATLE-ARASPE---MSDRIQQLEREISRY 747

  Fly  1050 KHDLERSQNVQKLMFETGKISTTFGRTTMTTSQELDRAQERADKASAELRRTQAELRVTQSDAER 1114
            |                               .|..:||...|:....|:..:.|    ::|.::
Mouse   748 K-------------------------------DESSKAQTEVDRLLEILKEVENE----KNDKDK 777

  Fly  1115 AREEAAALQEKLEKSQG-EVYRLKAKLENAQGEQESLRQELEKAQSGVSRIHADRDRAFSEVEKI 1178
            ...|..:|..:..|.|. :|..||.|            :::||.:|.                ::
Mouse   778 KIAELESLTSRQVKDQNKKVANLKHK------------EQVEKKKSA----------------QM 814

  Fly  1179 KEEMERTQATLGKSQLQHEKLQNSLDKAQNEVDHLQDKLDKA--CTENRRLVLEKEKLTYDYDNL 1241
            .||..|.:.:|..|.   ::||:||.|..:.::.|::.|.::  .|..|.:||.:|:..  ..|.
Mouse   815 LEEARRREDSLSDSS---QQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESA--RTNA 874

  Fly  1242 QSQLDKALGQAARMQKERETLSLDTDRIREKLEKTQVQLGRIQKERDQFSDELETLKERS----- 1301
            :.|:::.|....::::|.|::.......::.|.:.:..|..::.||.:..:|:..:|:.:
Mouse   875 EKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAI 939

  Fly  1302 --ESAQTLLMKAARDREAMQTDLEVLKERYEKSHAIQQKLQMERDDAVTEVEILKEKLDKALYAS 1364
              :.|...|::.:..::..|.::..||.  ||...:||..|..::    .::::.:..:...:.|
Mouse   940 SEKDANIALLELSSSKKKTQEEVAALKR--EKDRLVQQLKQQTQN----RMKLMADNYEDDHFRS 998

  Fly  1365 QK--LIDEKDTSNKEFEKMLE-KYDRAQNEIY--RLQSRCD----------------TAEADRAR 1408
            .:  ..:.|.:.::..:.:|| ..:|::.::|  .|.:.|.                .|:.::|.
Mouse   999 SRSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTALCHDRDPLILRGLTPPASYNADGEQAA 1063

  Fly  1409 LEVEAERSGLAASKAREDLRKLQDESTRLQEACDRAALQLSRAKECED------NARSE 1461
            .|.|.::  :...:.:.:|.|::.::..|||..:....|:  |..|.|      ||..|
Mouse  1064 WENELQK--MTQEQLQNELEKVEGDNAELQEFANTILQQI--ADHCPDILEQVVNALEE 1118

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brp	NP_001246228.1	KRTAP	332..401	CDD:256601	0/68 (0%)
		Myosin_tail_1	789..1824	CDD:279860	186/727 (26%)
		SMC_prok_B	1509..>2215	CDD:274008
		Bud13	2091..>2157	CDD:286779
Erc1	NP_444434.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..54		11/37 (30%)
		Cast	155..986	CDD:370855	269/1237 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	801..840		15/69 (22%)
		RBD-FIP	1072..1112	CDD:370506	9/41 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	188	1.000	Domainoid score	I3320
eggNOG	1	0.900	-	-		E1_KOG4809
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	370	1.000	Inparanoid score	I2114
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002038
OrthoInspector	1	1.000	-	-		otm43803
orthoMCL	1	0.900	-	-		OOG6_104556
Panther	1	1.100	-	-	O	PTHR18861
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3525
SonicParanoid	1	1.000	-	-		X1708
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.890