Protein Alignment brp and Erc1

DIOPT Version :10

• Sequence 1: NP_001400998.1
• Gene: brp / 35977
• FlyBaseID: FBgn0259246
• Length: 2243
• Species: Drosophila melanogaster
• Sequence 2: NP_444434.2
• Gene: Erc1 / 111173
• MGIID: 2151013
• Length: 1120
• Species: Mus musculus
• Alignment Length: 1552
• Identity: 326/1552 - (21%)
• Similarity: 590/1552 - (38%)
• Gaps: 549/1552 - (35%)

  Fly    15 RSPGRVRRLQELPTVDRSPSRDYGAPRGSPLAMGSPYYRDMDEPTSPAGAGHHRSRSASRPPMAH 79
            :||||..||...|.:....:...|...|:.:..||.....|:...|...|      .|:..||
Mouse    16 QSPGRSPRLPRSPRLGHRRTNSTGGSSGNSVGGGSGKTLSMENIQSLNAA------YATSGPM-- 72

  Fly    80 AMDYPRTRYQSLDRGGLVDPHDREFIPIREPRDRSRDRSLERGLYLEDELYGRSARQSP-----S 139
                    |.|          |.|.:....|:...              ..|||..:.|     :
Mouse    73 --------YLS----------DHENVGAETPKSTM--------------TLGRSGGRLPYGVRMT 105

  Fly   140 AMGGYN--TGMGPTSDRAYLG--------------------------DLQHQNTDLQRELGNLKR 176
            |||...  ...|..||....|                          |||.|..::.||...|::
Mouse   106 AMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRK 170

  Fly   177 ELELTNQKLGSSMHSIKTFWSPELKKERALRKEESAKYSLINDQLKLLSTENQKQAMLVRQLEEE 241
            ::|:...||.|||:||||||||||||||||||:|::|.::..:|.:::..|||...|.::.|::|
Mouse   171 DVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDE 235

  Fly   242 LRLRMRQPNLEMQQ-----------------QMEAIYAENDHLQREISILRETIKDLECRVETQK 289
            ||:: |..|...||                 ..:.::||::...:|:.:||:|::::|.|:||||
Mouse   236 LRIQ-RDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQK 299

  Fly   290 QTLIARDESIKKLLEMLQAKGMGKEEERQMFQQMQAMAQKQMYNNYTGASGSSPPLPDIIGQYYG 354
            |||.||||||||||||||:||:..:...:..::.:.:|:.:|:.::
Mouse   300 QTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHH------------------- 345

  Fly   355 PGSLGPGPLSYGSGNGYGPPGYDLYGPSTSTAAGGYGLYDPQIYGPCQQTSPIRRRRYSIAGLPS 419
                                                                          |.|
Mouse   346 --------------------------------------------------------------LES 348

  Fly   420 ATMYNDVYGYPAPPLQQTSSSNIVNLLNEAHKSISRSSQILNLTNQARQLGQLVTTPLGGGGVGM 484
            .             |:|....|  |:|.|
Mouse   349 L-------------LEQKEKEN--NMLRE------------------------------------ 362

  Fly   485 GLGRVVSSYPTLHPGDTSPPYLNDNLMQMSTSFSSQPNMYFQPQAQVQQVLPTQLTAAQSAAAAA 549
                                       :|...|.:.|:                          :
Mouse   363 ---------------------------EMHRRFENAPD--------------------------S 374

  Fly   550 ARLRPAYSVTNLVSSYPTTTAAGYGCKYGGYGNPYQSDLGYGNPLAPFQQRQLMAHQSLHASNPA 614
            |:.:...:|..:..|..::...|.                          |.|.....:..||.|
Mouse   375 AKTKALQTVIEMKDSKISSMERGL--------------------------RDLEEEIQMLKSNGA 413

  Fly   615 ISQYYQNQGAATGTGASAAALAYNLQQQFAGTQHYGGGSQGPPLGHSHIQASVQQQMHPQYQYHV 679
            :|.                                                  :::.....|..|
Mouse   414 LSS--------------------------------------------------EEREEEMKQMEV 428

  Fly   680 HQHQNHLQTHPLAALANTSGPFGGTLASSARDYVDGLHHAAHSHTHPHSHPHHSSHHSHHTAYPH 744
            ::
Mouse   429 YR--------------------------------------------------------------- 430

  Fly   745 SHSHHQQQQPHQAHHHHHLPYSKLDLDYPKLPQEH---KRQLDEFRLEIQRRDQEILAMAAKMKT 806
            |||...:.:..|....    .|..|....:|.:..   :.::.:.:.|:.|:|.|:||:..|::|
Mouse   431 SHSKFMKNKVEQLKEE----LSSKDAQGEELKKRAAGLQSEIGQVKQELSRKDTELLALQTKLET 491

  Fly   807 LEEQHQDYQRHIAVLKESLCAKEEHYNMLQTDVEEMRARLEEKNRLIEKKTQGTLQTVQERNRLT 871
            |..|..|.::||.||||||.|||:...:|||:|:.:|.|||||..::.|||:......:|:....
Mouse   492 LTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQA 556

  Fly   872 SELTELKDHMDIKDRKISVLQRKIENLEDLLKEKDNQVDMARARLSAMQAHHSSSEGALTSLEEA 936
            .|:.:|||.:|:|:||::|||:|||||::.|::|:.|:...:.|:.::||..::::.|||:||||
Mouse   557 GEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEA 621

  Fly   937 IGDKEKQMAQLRDQRDRAEHEKQEERDLHEREVADYKIKLRAAESEVEKLQTRLERAVTERERLE 1001
            :.|||:.:.:|::||||.|.|||||.|.:::::.|.:.|:...:.::.:.:..|         |:
Mouse   622 LADKERTIERLKEQRDRDEREKQEEIDTYKKDLKDLREKVSLLQGDLSEKEASL---------LD 677

  Fly  1002 IKLEASQSELGKSKAELEKATCEMGRSSADWESTKQRIARLELENERLKHDLERSQMQLEEQTTL 1066
            ||..||    ..:.:.|:|               ..|:..||:..|:.|.:..:.:.||
Mouse   678 IKEHAS----SLASSGLKK---------------DSRLKTLEIALEQKKEECLKMESQL------ 717

  Fly  1067 HKTTFGRTTMTTSQELDRAQERADKASAELRRTQAELRVTQGETEKRFSDAERAREEAAALQEKL 1131
                                ::|.:|:.|.|.:.        |...|....||   |.:..:::.
Mouse   718 --------------------KKAHEATLEARASP--------EMSDRIQQLER---EISRYKDES 751

  Fly  1132 EKSQGEVYRLKAKLENAQGEQESLRQELEKAQSGVSRIHADRDRAFS------EVEKIK-----E 1185
            .|:|.||.||...|:..:.|:....:::.:.:|..||...|:::..:      :|||.|     |
Mouse   752 SKAQTEVDRLLEILKEVENEKNDKDKKIAELESLTSRQVKDQNKKVANLKHKEQVEKKKSAQMLE 816

  Fly  1186 EMERTQATLGKSQLQHEKLQNSLDKAQNEVDHLQDKLDKA--CTENRRLVLEKEKLTYDYDNLQS 1248
            |..|.:.:|..|.   ::||:||.|..:.::.|::.|.::  .|..|.:||.:|:..  ..|.:.
Mouse   817 EARRREDSLSDSS---QQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESA--RTNAEK 876

  Fly  1249 QLDKALGQAARMQKERETLSLDTDRIREKLEKTQVQLGRIQKERDQFSDELETLKERS------- 1306
            |:::.|....::::|.|::.......::.|.:.:..|..::.||.:..:|:..:|:.:
Mouse   877 QVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISE 941

  Fly  1307 ESAQTLLMKAARDREAMQTDLEVLKERYEKSHAIQQKLQMERDDAVTEVEILKEKLDKALYASQK 1371
            :.|...|::.:..::..|.::..||.  ||...:||..|..::    .::::.:..:...:.|.:
Mouse   942 KDANIALLELSSSKKKTQEEVAALKR--EKDRLVQQLKQQTQN----RMKLMADNYEDDHFRSSR 1000

  Fly  1372 --LIDEKDTSNKEFEKMLE-KYDRAQNEIY--RLQSRCD----------------TAEADRARLE 1415
              ..:.|.:.::..:.:|| ..:|::.::|  .|.:.|.                .|:.::|..|
Mouse  1001 SNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTALCHDRDPLILRGLTPPASYNADGEQAAWE 1065

  Fly  1416 VEAERSGLAASKAREDLRKLQDESTRLQEACDRAALQLSRAKECED------NARSE 1466
            .|.::  :...:.:.:|.|::.::..|||..:....|:  |..|.|      ||..|
Mouse  1066 NELQK--MTQEQLQNELEKVEGDNAELQEFANTILQQI--ADHCPDILEQVVNALEE 1118

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brp	NP_001400998.1	Cast	160..>313	CDD:431111	76/169 (45%)
		Cast	<780..1186	CDD:431111	122/416 (29%)
		SMC_prok_B	870..1664	CDD:274008	148/644 (23%)
		SMC_prok_B	1427..2214	CDD:274008	12/46 (26%)
Erc1	NP_444434.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..54		11/37 (30%)
		Cast	154..986	CDD:431111	268/1236 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	801..840		14/41 (34%)
		RBD-FIP	1072..1112	CDD:462805	9/41 (22%)