DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brp and Numa1

DIOPT Version :9

Sequence 1:	NP_001246228.1	Gene:	brp / 35977	FlyBaseID:	FBgn0259246	Length:	2238	Species:	Drosophila melanogaster
Sequence 2:	XP_006507232.1	Gene:	Numa1 / 101706	MGIID:	2443665	Length:	2108	Species:	Mus musculus

Alignment Length:	1797	Identity:	409/1797 - (22%)
Similarity:	721/1797 - (40%)	Gaps:	479/1797 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   771 DYPKLPQEHKRQL-DEFRLEIQRRDQEILAMAAKMKTLEEQHQD----YQR--HIAVLKESLCAK 828
            |..:.||...|:| .:...|...||...|.::..:|.|.|:...    .||  |:|:|.|...|.
Mouse   205 DILQTPQFQMRRLKKQLADERSNRDDLELELSESLKLLTEKDAQIAMMQQRIDHLALLNEKQAAS 269

  Fly   829 EEHYNMLQTDVEEMRARLEEKNRLIEKKTQGTLQTVQERNRLTSELTELKDHMDIKDRKISVLQR 893
            .:.    .:::||:|.    ||..:..:...||:..|          .||......|||||.|..
Mouse   270 SQE----PSELEELRG----KNESLTVRLHETLKQCQ----------NLKTEKSQMDRKISQLSE 316

  Fly   894 KIENLEDLLKEKDNQVDMARARLSAMQAHHS--SSEGA------LTSLEEAIGDK----EK---- 942
            :..:|...::|..|.:...:...:.:...||  |.|.|      ...|..|:.||    ||
Mouse   317 ENGDLSFKVREFANHLQQLQGAFNDLIEEHSKASQEWAEKQARLENELSTALQDKKCLEEKNEIL 381

  Fly   943 --QMAQLRDQRDRAEHEKQEERDLHEREVADYKIKLRAAESEVEKLQTRLERAVTERERLEIKLE 1005
              :::||.||..|.:.....|:.    ||....::|...:.|..||       .|:..:|:.::|
Mouse   382 QGKLSQLEDQATRLQESPAPEKG----EVLGDALQLDTLKQEAAKL-------ATDNTQLQTRVE 435

  Fly  1006 ASQSELGKSKAELEKATCEMGRSSADWESTKQRIARL--ELEN-----ERLKHDLERSQNVQKLM 1063
            ..:.|.||.:|:|   ..|..|    :|..||::|.|  :|::     .:.|.:||::...|...
Mouse   436 TLECERGKQEAQL---LAERSR----FEDEKQQLASLIADLQSSVSNLSQAKEELEQASQAQGAQ 493

  Fly  1064 FETGKISTTFG--RTTMTTSQELDRAQERADKASAELRRTQAELRVTQSDAERAREEAA-ALQEK 1125
            . |.::::..|  .|.....|||...:|:|.|..|::.:|..|           :|:|| .|:::
Mouse   494 L-TAQLTSMTGLNATLQQRDQELASLKEQAKKEQAQMLQTMQE-----------QEQAAQGLRQQ 546

  Fly  1126 LEKSQGEVYRLKAKLENAQGEQESLRQE-------LEKAQSGVSRIHADRDRAFSEVEKIKEEME 1183
            :|:....:...:.:||.|..|||:.||:       :.:|:....|   :||.|..::|.:::|.:
Mouse   547 VEQLSSSLKLKEQQLEEAAKEQEATRQDHAQQLAIVAEAREASLR---ERDTARQQLETVEKEKD 608

  Fly  1184 RTQATLGKSQLQ-----HEKLQNSLDKAQNEVDHLQDKLDK--ACTENRRLVLEKEKLTYDYDNL 1241
            ....:| :.|||     .:..|.|:.:||.|...|..|:.:  ||.|...  .|:.::......|
Mouse   609 AKLESL-QQQLQAANDARDNAQTSVTQAQQEKAELSQKIGELHACIEASH--QEQRQVQARVTEL 670

  Fly  1242 QSQLDKALGQAARMQK--ERETLSLDTDRIREKL----EKTQVQLGRIQKERDQFSDELETLKER 1300
            ::||      .|..||  |||.:..:..:::|:|    |..::..|.:::|:.:.:|.|:..:.|
Mouse   671 EAQL------KAEQQKTTEREKVVQEKAQLQEQLRALEESLKITKGSLEEEKRRAADALKEQQCR 729

  Fly  1301 SESAQTLLMKAARDREAMQTDLEVLKERYEKS--HAIQQKLQMERDDAVTEVEILKEKLDKALYA 1363
            :...:.........||..|.:||     .||:  ..::.::|...:....|.|.|:.:|.:|. |
Mouse   730 ATEMEAESRSLMEQREREQKELE-----QEKAGRKGLEARIQQLEEAHQAETEALRHELAEAT-A 788

  Fly  1364 SQ--------KLIDEKDTSNKEFEKMLEKYDR----AQNEIYRLQSRCDTAEADRARLEVEAE-- 1414
            ||        :||.|.::..|.||...::..|    .|.::..|:......|.....:|:.:|
Mouse   789 SQHRAESECERLIREVESRQKRFEARQQEEARYGAMFQEQLMALKGEKTGQEVQEEAVEIHSEGQ 853

  Fly  1415 ----RSGLA---ASKAREDLRKLQDESTRLQEAC-DRAALQLSRAKECEDNARSELEHSRDRFDK 1471
                :|.||   ||.|:. ::::|::..|.|:.. |.:|||...|...::.|            .
Mouse   854 PGQQQSQLAQLHASLAKA-IQQVQEKEVRAQKLVDDLSALQEKMAATNKEVA------------C 905

  Fly  1472 LQTDIRRAQGEKEHFQSELERVTYELERAHAAQTKAS---------------ASVEAAKEEAAHY 1521
            |:|.:.:|..::|....||      |:....|..:||               |:|:|.:.||...
Mouse   906 LKTLVLKAGEQQETASLEL------LKEPPRAANRASDQLGEQQGRPFSSTHAAVKAMEREAEQM 964

  Fly  1522 AVELEKMRDRYEKS---QVELRKLQDTDTFGRETRRLKEENERLREKLDKTLMELETIRGKSQYE 1583
            ..|||::|....||   |.|.|..|:     ||..||.:|                  ||::|.:
Mouse   965 GGELERLRAALIKSQGQQQEERGQQE-----REVARLTQE------------------RGQAQAD 1006

  Fly  1584 SESFEKYKDKYEKIEMEVQNMESKLHETSLQLELSKGEVAKMLANQEKQRSELERAHIEREKARD 1648
            ..     ::|..|.|:|:: :::.|:|..::....:..:|..|..:|....||.:...:....|.
Mouse  1007 LA-----QEKAAKAELEMR-LQNTLNEQRVEFAALQEALAHALTEKEGTDQELAKLRGQEAAQRT 1065

  Fly  1649 KHEKLLKEVDRLRLQQSSVSPGDPV------RASTSSSSALSAGERQ----EIDRLRDRLEKALQ 1703
            :.::|.:.:::|::|........|.      .||...:.:.:||:..    |:..||..:.|..|
Mouse  1066 ELKELQQTLEQLKIQLVKKEKEHPAGGASGEDASGPGTQSETAGKTDAPGPELQALRAEISKLEQ 1130

  Fly  1704 SRDATELEAGRLAKELEKAQMHLAKQQENTESTRIEFERMGAELGRLHDRLEKAEAERE--ALRQ 1766
            .....:.:...|...|:..:...|:|.:..|:.:.:.|....|||  |::...|.|:||  |||
Mouse  1131 QCQQQQQQVEGLTHSLKSERACRAEQDKALETLQGQLEEKARELG--HNQAASASAQRELQALR- 1192

  Fly  1767 ANRSGGAGAAPHPQLEKH------------------VQKLESDVKQL---AMERE--------QL 1802
                  |.|..|.:.|:.                  :..||.:|..|   .:|:|        .:
Mouse  1193 ------AKAQDHSKAEEEWKAQVARGQQEAERKSSLISSLEEEVSILNRQVLEKEGESKELKRLV 1251

  Fly  1803 VLQLEKSQEI-----LMNFQKELQNAEA---------ELQKTREENRKLR----NGHQVPPVAAP 1849
            |.:.||||::     |:..:....:|.|         |:|..|||..|.|    |..|.....|.
Mouse  1252 VAESEKSQKLEERLRLLQVETASNSARAAERSSALREEVQSLREEVEKQRVVSENSRQELASQAE 1316

  Fly  1850 PAGPSPAEFQAMQKEIQTLQQKLQESERALQAAGPQ---------------------QAQAAAAA 1893
            .|       :.:.:|::..|:|..:.|:||.|...:                     ||:.|||.
Mouse  1317 RA-------EELGQELKAWQEKFFQKEQALSALQLEHTSTQALVSELLPAKHLCQQLQAEQAAAE 1374

  Fly  1894 GASREEIEQWR-------------------------KVIEQEKS----RADMADKAAQ-----EM 1924
            ...|||:||.:                         |::|||::    ||:.|..|.|     :.
Mouse  1375 KRFREELEQSKQAAGGLQAELMRAQRELGELGSLRQKIVEQERAAQQLRAEKASYAEQLSMLKKA 1439

  Fly  1925 H-----------KRIQLMDQHIKDQHAQ-MQKMQQQMQQQQQAAQQAVQQAAQQQQSAAGAGGAD 1977
            |           :|..|..|.::.:..| .:|..|::...:..|:..:.:..|:.||.:
Mouse  1440 HGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRTDAETHLAEMRQEAQSTS------ 1498

  Fly  1978 PKELE----KVRGELQAACTERDRFQQQLELLVTELEKSKMSNQEQAKQLQ-------------- 2024
             :|||    |..|.......||.|||::.:.|..::|:.::..:||.||::
Mouse  1499 -RELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLTEHDQASK 1562

  Fly  2025 --------------TAQQQVQQLQQQVQQLQQQMQQLQQA----------ASAGAGATDVQRQQL 2065
                          .:||:||:||.|:.:||.|:.|.:||          |.....|...|.|:|
Mouse  1563 VQQQKLKAFQAQRGESQQEVQRLQTQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQKL 1627

  Fly  2066 EQQQKQLEEVRKQIDNQAKATEGERKIIDEQRKQIDAKRKDIEEK-----------EKKMAEFDV 2119
            ::|.:.|||::|  :|:...:|.||  :..:.:|...|.|:.|:.           |.::|..|.
Mouse  1628 QEQLQDLEELQK--ENKELRSEAER--LGRELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQ 1688

  Fly  2120 QLR------------KRKE---------QMDQLEKSLQ-------------TQGGGAAAAGE--- 2147
            |||            |.:|         .:|.|:.||:             ||..|.:..||
Mouse  1689 QLRDLGKFQVATDALKSREPQVKPQLDLSIDSLDLSLEEGTPCSVASKLPRTQPDGTSVPGEPAS 1753

  Fly  2148 -LNKKLMDT----------------QRQLEACVKELQNT-KEEHKKAATETERLLQLVQMSQ--- 2191
             ::::|...                |..||..:..|.:. .:..:|..:...|..|::.::.
Mouse  1754 PISQRLPPKVESLESLYFTPTPARGQAPLETSLDSLGDAFPDSGRKTRSARRRTTQIINITMTKK 1818

  Fly  2192 ---EEQNAKEKTIMDLQQALKIAQAKVKQAQTQQQQQQDAGP 2230
               ||.::...:....|.| ..:||.::...:.|...:...|
Mouse  1819 LELEEPDSANSSFYSTQSA-PASQANLRATSSTQSLARLGSP 1859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brp	NP_001246228.1	KRTAP	332..401	CDD:256601
		Myosin_tail_1	789..1824	CDD:279860	274/1176 (23%)
		SMC_prok_B	1509..>2215	CDD:274008	209/948 (22%)
		Bud13	2091..>2157	CDD:286779	22/130 (17%)
Numa1	XP_006507232.1	SMC_prok_B	<211..844	CDD:274008	169/698 (24%)
		SMC_prok_B	554..1323	CDD:274008	194/850 (23%)
		SMC_prok_B	1003..>1695	CDD:274008	162/724 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000