Protein Alignment brp and smyhc2

DIOPT Version :10

• Sequence 1: NP_001400998.1
• Gene: brp / 35977
• FlyBaseID: FBgn0259246
• Length: 2243
• Species: Drosophila melanogaster
• Sequence 2: NP_001096096.2
• Gene: smyhc2 / 100124599
• ZFINID: ZDB-GENE-070822-12
• Length: 1939
• Species: Danio rerio
• Alignment Length: 1419
• Identity: 299/1419 - (21%)
• Similarity: 596/1419 - (42%)
• Gaps: 347/1419 - (24%)

  Fly   785 EFRLEIQRRDQEILA-------MAAK--------------MKTLEEQHQ--DYQRHIAVLKESLC 826
            ||:..::|||..::.       |..|              :||.|.:.:  :.:.....|||:..
Zfish   803 EFQKIVERRDSLLVIQWNVRAFMGVKNWPWMKLYFKIKPLLKTAETEKEMANMKEEFTKLKEAYA 867

  Fly   827 AKEEHYNMLQTDVEEMRARLEEKN--RLIEKKTQGTLQTVQER--------NRLTSELTELKDHM 881
            ..|.....|:   |:|.:.|:|||  :|..:..|..|...:||        .:..:::.||.:.:
Zfish   868 KSEARKKELE---EKMVSLLQEKNDLQLAVQSEQDNLADAEERCEGLIKSKIQFEAKVKELTERL 929

  Fly   882 DIKDRKISVLQRKIENLEDLLKEKDNQVDMARARLSAMQAHHSSSEGALTSLEEAIGDKEKQMAQ 946
            :.::...:.|..|...|||...|....:|.....|:.::....::|..:.:|.|       :||.
Zfish   930 EDEEEMNAELVAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTE-------EMAA 987

  Fly   947 LRDQRDRAEHEKQEERDLHEREVADYKIKLRAAESEVEKLQTRLERAVTERERLEIKLEASQSEL 1011
            |.:...:...||:..::.|::.:.|       .:||.:|:.| |.:|..:.|:....||.|..:.
Zfish   988 LDEIIAKLTKEKKALQEAHQQTLDD-------LQSEEDKVNT-LTKAKAKLEQQVDDLEGSLEQE 1044

  Fly  1012 GKSKAELEKATCEMGRSSADWESTKQRI-ARLELENERLKHDLERSQMQLEEQTTLHKTTFGRTT 1075
            .|.:.:||:|              |::: ..|:|..|.|. |||..:.|:||:  |.|..|..:.
Zfish  1045 KKIRMDLERA--------------KRKLEGDLKLTQENLM-DLENDKQQMEER--LKKKDFEISQ 1092

  Fly  1076 MTTSQELDRAQERADKASAELRRTQAELRVTQGETEKRFSDAERAREEAAALQEKLEKSQGEVYR 1140
            :.:..|.::|.|      |:|::...||:....|.|:.. :|||      |.:.|:||.:.::.|
Zfish  1093 LNSKIEDEQALE------AQLQKKLKELQARIEELEEEL-EAER------AARAKVEKQRADLSR 1144

  Fly  1141 LKAKLENAQGEQESLRQELEKAQSG-VSRIHADRDRAFSEVEKIKEEMERTQATLGKSQLQHEKL 1204
                      |.|.:.:.||:|... .::|..::.|. :|.:|::.::|  :||     ||||..
Zfish  1145 ----------ELEEISERLEEAGGATAAQIEMNKKRE-AEFQKLRRDLE--EAT-----LQHEAT 1191

  Fly  1205 QNSLDKAQ-NEVDHLQDKLDKACTENRRLVLEKEKLTYDYDNLQSQLDKALGQAARMQKERETLS 1268
            .::|.|.. :.|..|.:::|......::|..||.:|..:.|::.|.:::.:...|.::|...||.
Zfish  1192 ASTLRKKHADSVSDLGEQIDNLQRVKQKLEKEKSELRLELDDVVSNMEQIVKAKANLEKMCRTLE 1256

  Fly  1269 LDTDRIREKLEKTQ-------VQLGRIQKERDQFSDELETLKERSESAQTLLMKAARDREAMQTD 1326
            ......|.|.|:.|       :|..::|.|..:.|.:|       |...:|:.:..|.:::....
Zfish  1257 DQMSEYRTKAEEGQRTINDFTMQKAKLQTENGELSRQL-------EEKDSLVSQLTRGKQSYTQQ 1314

  Fly  1327 LEVLKERYEK----SHAIQQKLQMERDDAVTEVEILKEKLDKALYASQKLIDEKDTSNKEFEKML 1387
            :|.||.:.|:    .:|:...:|..|.||    |:|:|:           .:|:..:..|.::.|
Zfish  1315 IEDLKRQLEEEVKAKNALAHAVQSARHDA----ELLREQ-----------YEEEQEAKAELQRSL 1364

  Fly  1388 EKYDRAQNEIYRLQSRCDTAEADRARLEVEAERSGLAASKAREDLRKLQDESTRLQEACDRAALQ 1452
            .|   |.:|:.:.:::.:|....|.. |:|..:..||               .|||:|  ..|::
Zfish  1365 SK---ANSEVAQWRTKYETDAIQRTE-ELEEAKKKLA---------------QRLQDA--EEAVE 1408

  Fly  1453 LSRAKECEDNARSELEHSRDRFDKLQTDIRRAQGEKEHFQSELERVTYELERAHAAQTKASASVE 1517
            ...|| |     |.||.::.|                 .|:|:|.:..::||::||       ..
Zfish  1409 AVNAK-C-----SSLEKTKHR-----------------LQNEIEDLMVDVERSNAA-------AA 1443

  Fly  1518 AAKEEAAHYAVELEKMRDRYEKSQVELRKLQDTDTFGRETRRLKEENERLREKLDKTLMELETIR 1582
            |..::..::...|.:.:.:||:||.||...|      :|:|.|..|..:|:
Zfish  1444 ALDKKQRNFDKVLAEWKQKYEESQTELESAQ------KESRSLSTELFKLK-------------- 1488

  Fly  1583 GKSQYESESFEKYKDKYEKIEMEVQNMESKLHETSLQLELSKGEVAKMLANQEKQRSELERAHIE 1647
                   .|:|:..|..|.::.|.:|::.::.:.:.||    ||..|.:...||.|.:||:...|
Zfish  1489 -------NSYEESLDHLESMKRENKNLQEEISDLTEQL----GESGKNIHELEKVRKQLEQEKQE 1542

  Fly  1648 REKARDKHEKLLKEVDRLRLQQSSVSPGDPVRASTSSSSALSAGERQEIDRLRDRLEKALQSRDA 1712
            .:.|.::.|..|:..:           |..:||            :.|.::::..:|:.|..:|
Zfish  1543 IQTALEEAEGSLEHEE-----------GKILRA------------QLEFNQVKADIERKLSEKD- 1583

  Fly  1713 TELEAGRLAKELEKAQMHLAKQQENTESTRIEFERMGAELGRLHDRLE-KAEAEREALRQANRSG 1776
                     :|:|:|:    :.|:....|             |...|| :..:..||||
Zfish  1584 ---------EEMEQAK----RNQQRVVDT-------------LQSSLESETRSRNEALR------ 1616

  Fly  1777 GAGAAPHPQLEKHVQKLESDVKQLAMEREQLVLQLEKSQEILMNFQKELQNAEAELQKTREENRK 1841
                     |:|   |:|.|:.::.::..|...|..::|:.|......|::|:.:|......|..
Zfish  1617 ---------LKK---KMEGDLNEMEIQLSQANRQASEAQKQLKGLHGHLKDAQLQLDDALRGNDD 1669

  Fly  1842 LRNGHQVPPVAAPPAGPSPAEFQAMQKEIQTLQQKLQESERALQAAGPQQAQAAAAAGASREEIE 1906
            |:....:                            ::.....|||                 |::
Zfish  1670 LKENIAI----------------------------VERRNNLLQA-----------------ELD 1689

  Fly  1907 QWRKVIEQEKSRADMADKAAQEMHKRIQLMDQHIKDQHAQMQKMQQQMQQQQQAAQQAVQQAAQQ 1971
            :.|.::||.:....:|::...::.:|:||:.........|.:|::....|.|...::|||:....
Zfish  1690 ELRSLVEQTERGRKLAEQELMDVSERVQLLHSQNTSLLNQKKKLEGDNTQLQTEVEEAVQECRNA 1754

  Fly  1972 QQSAAGAGGADPKELEKVRGELQAACTERDRFQQQLELLVTELEKSKMSNQEQAKQLQTAQQQVQ 2036
            ::.|..|........|:::.| |......:|.::.:|..:.:|: .::...||. .::..::|||
Zfish  1755 EEKAKKAITDAAMMAEELKKE-QDTSAHLERMKKNMEQTIKDLQ-HRLDEAEQI-AMKGGKKQVQ 1816

  Fly  2037 QLQQQVQQLQQQMQQLQQAASAGAGATDVQRQQLEQQQKQLEEVRKQIDNQAKATEGERKIIDEQ 2101
            :|:.:|::|:.:::..|:.||..........:::::...|.||.||   |.|:..:    ::|:.
Zfish  1817 KLESRVRELESEVEMEQRKASDSVKGVRKYERRIKELTYQTEEDRK---NLARLQD----LVDKL 1874

  Fly  2102 RKQIDAKRKDIEEKEKKMAEFDVQLRKRKEQMDQLEKSLQTQGGGAAAAGELNK 2155
            :.::.:.::..||.|::......:.||.:.::|:.|:...      .|..::||
Zfish  1875 QLKVKSYKRTAEEAEEQANSNLGKFRKLQHELDEAEERAD------IAESQVNK 1922

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brp	NP_001400998.1	Cast	160..>313	CDD:431111
		Cast	<780..1186	CDD:431111	100/435 (23%)
		SMC_prok_B	870..1664	CDD:274008	185/807 (23%)
		SMC_prok_B	1427..2214	CDD:274008	141/730 (19%)
smyhc2	NP_001096096.2	Myosin_N	32..76	CDD:460670
		MYSc_class_II	99..769	CDD:276951
		Myosin_tail_1	849..1926	CDD:460256	289/1373 (21%)