Protein Alignment Wnt2 and WNT7A

DIOPT Version :9

• Sequence 1: NP_476810.1
• Gene: Wnt2 / 35975
• FlyBaseID: FBgn0004360
• Length: 352
• Species: Drosophila melanogaster
• Sequence 2: NP_004616.2
• Gene: WNT7A / 7476
• HGNCID: 12786
• Length: 349
• Species: Homo sapiens
• Alignment Length: 340
• Identity: 168/340 - (49%)
• Similarity: 223/340 - (65%)
• Gaps: 21/340 - (6%)

  Fly    21 VSSFTSV------MLCGRIPGLTPGQRNMCREMPDALIALGEGHQLGAQECQHQFRGHRWNCSEV 79
            :..|:||      ::|.:||||.|.||.:|:..|||:|.:|||.|:|..|||.|||..|||||.:
Human    23 IGGFSSVVALGASIICNKIPGLAPRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSAL 87

  Fly    80 WQRNVFAHVIPTASREAAYTYAIASAGAAYAVTAACARGNISTCGCDVRHKATPTGGGTPDEPWK 144
            .:|.||...:...|||||:||||.:||.|:|:||||.:||:|.||||...:    |....||.||
Human    88 GERTVFGKELKVGSREAAFTYAIIAAGVAHAITAACTQGNLSDCGCDKEKQ----GQYHRDEGWK 148

  Fly   145 WGGCSADVDFGMRYARRFMDARELERDSRTLMNLHNNRAGRTLVKKMLRTDCKCHGVSGSCVMKT 209
            |||||||:.:|:.:|:.|:||||:::::|||||||||.|||.::::.::.:||||||||||..||
Human   149 WGGCSADIRYGIGFAKVFVDAREIKQNARTLMNLHNNEAGRKILEENMKLECKCHGVSGSCTTKT 213

  Fly   210 CWKSLPPFRLVGDRLMLKYQKAKTVQAVKGKRGLRLVLSRKKHAGTARAQKPVLDWPKRM--ELI 272
            ||.:||.||.:|..|..||.:|..|:.|:.        ||.|.....:.:|| |.:.|.|  :|:
Human   214 CWTTLPQFRELGYVLKDKYNEAVHVEPVRA--------SRNKRPTFLKIKKP-LSYRKPMDTDLV 269

  Fly   273 YLEASPNYCERSLQTGSQGTSGRTCQRTGHGPQSCDLLCCGRGHNTQHIRRTTQCRCQFRWCCEV 337
            |:|.||||||....|||.||.||.|.:|......|||:|||||:||....|..||.|:|.|||.|
Human   270 YIEKSPNYCEEDPVTGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYV 334

  Fly   338 KCDECDESYEEFTCK 352
            ||:.|.|..|.:|||
Human   335 KCNTCSERTEMYTCK 349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wnt2	NP_476810.1	wnt	36..352	CDD:278536	159/317 (50%)
WNT7A	NP_004616.2	Wnt_Wnt7a	32..349	CDD:381723	163/329 (50%)
		Disordered linker. /evidence=ECO:0000269|PubMed:30026314	238..266		10/36 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152260
Domainoid	1	1.000	350	1.000	Domainoid score	I1024
eggNOG	1	0.900	-	-		E1_KOG3913
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	356	1.000	Inparanoid score	I2234
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D326151at33208
OrthoFinder	1	1.000	-	-		FOG0002358
OrthoInspector	1	1.000	-	-		otm40508
orthoMCL	1	0.900	-	-		OOG6_107270
Panther	1	1.100	-	-	O	PTHR12027
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X108
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.760