Protein Alignment Wnt2 and WNT3

DIOPT Version :10

• Sequence 1: NP_476810.1
• Gene: Wnt2 / 35975
• FlyBaseID: FBgn0004360
• Length: 352
• Species: Drosophila melanogaster
• Sequence 2: NP_110380.1
• Gene: WNT3 / 7473
• HGNCID: 12782
• Length: 355
• Species: Homo sapiens
• Alignment Length: 349
• Identity: 164/349 - (46%)
• Similarity: 208/349 - (59%)
• Gaps: 23/349 - (6%)

  Fly    11 YILWIMEIRLVSSFTSV----MLCGRIPGLTPGQRNMCREMPDALIALGEGHQLGAQECQHQFRG 71
            |.:| ..:.|...:||:    :|||.||||.|.|...||...:.:.::.||.:||.|||||||||
Human    23 YPIW-WSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRG 86

  Fly    72 HRWNCSEVWQR-NVFAHVIPTASREAAYTYAIASAGAAYAVTAACARGNISTCGCDVRHKATPTG 135
            .||||:.:... .:|..|:..|:||:|:.:||||||.|:|||.:||.|..:.||||..||
Human    87 RRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHK----- 146

  Fly   136 GGTPDEPWKWGGCSADVDFGMRYARRFMDARELERDSRTLMNLHNNRAGRTLVKKMLRTDCKCHG 200
             |.|.|.|||||||.|.|||:..:|.|.||||...|:|:.||.|||.||||.:...:...|||||
Human   147 -GPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHG 210

  Fly   201 VSGSCVMKTCWKSLPPFRLVGDRLMLKYQKAK--TVQAVKGKRGLRLVLSRKKHAGTARAQKPVL 263
            :||||.:||||.:.|.||.:||.|..||..|.  .|:..:..||         ...|.||:..:.
Human   211 LSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRG---------WVETLRAKYSLF 266

  Fly   264 DWPKRMELIYLEASPNYCERSLQTGSQGTSGRTCQRTGHGPQSCDLLCCGRGHNTQHIRRTTQCR 328
            ..|...:|:|.|.|||:||.:.:|||.||..|||..|.||...||||||||||||:..:|..:|.
Human   267 KPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCH 331

  Fly   329 CQFRWCCEVKCDECDESYEEFTCK 352
            |.|.|||.|.|.||...|:..|||
Human   332 CIFHWCCYVSCQECIRIYDVHTCK 355

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Wnt2	NP_476810.1	Wnt_Wnt7	29..352	CDD:381713	157/325 (48%)
WNT3	NP_110380.1	Wnt_Wnt3_Wnt3a	42..355	CDD:381709	157/327 (48%)