DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wnt2 and wnt8a

DIOPT Version :9

Sequence 1:	NP_476810.1	Gene:	Wnt2 / 35975	FlyBaseID:	FBgn0004360	Length:	352	Species:	Drosophila melanogaster
Sequence 2:	NP_571021.3	Gene:	wnt8a / 30122	ZFINID:	ZDB-GENE-980526-332	Length:	359	Species:	Danio rerio

Alignment Length:	347	Identity:	126/347 - (36%)
Similarity:	179/347 - (51%)	Gaps:	28/347 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 RLVSSFTSVMLCGRIPGLTPGQRNMCREMPDALIALGEGHQLGAQ----ECQHQFRGHRWNCSEV 79
            ::.:|....:.|..:........|.....|.|.:|.....|.|||    ||:|||...||||.|.
Zfish     5 QIFASLVMSICCHILSSTAWSVNNFLMTGPKAYLAYTSSVQAGAQSGIEECKHQFAWDRWNCPES 69

  Fly    80 WQRNVFAHVIPTASREAAYTYAIASAGAAYAVTAACARGNISTCGCDVRHKATPTGGGTPDEPWK 144
            ..:......:.:|:||.|:.:||::||..|.:|..|:.|:...|||| ..|....||    ..|.
Zfish    70 ALQLSTHKGLRSATRETAFVHAISAAGVMYTLTKNCSMGDFENCGCD-DSKIGKMGG----RGWV 129

  Fly   145 WGGCSADVDFGMRYARRFMDARELERDSRTLMNLHNNRAGRTLVKKMLRTDCKCHGVSGSCVMKT 209
            |||||.:|:||.|.|:.|:||.|...|||..:|||||.|||..||..|:..|||||:||||.::|
Zfish   130 WGGCSDNVNFGDRIAKLFVDALENGHDSRAAVNLHNNEAGRLAVKATLKRTCKCHGLSGSCSIQT 194

  Fly   210 CWKSLPPFRLVGDRLMLKYQKAKTVQAVKGKRGLRLVLSRKKHAGTARAQKPVLDW---PKRMEL 271
            ||..|..||.:|..|.:|:.:|:.::..|         .|.:...:|..:..:.|.   ..|.||
Zfish   195 CWMQLADFRDIGSYLKIKHDQARKLEMDK---------IRMRAGNSADNRGAIADTFSAVARTEL 250

  Fly   272 IYLEASPNYCERSLQTGSQGTSGRTCQRTGHG-----PQSCDLLC--CGRGHNTQHIRRTTQCRC 329
            |::|.||:||.::|..|..||.||.|.::|..     .:||..||  ||.....:.|...:.|.|
Zfish   251 IFMEDSPDYCVKNLSMGLHGTEGRECLQSGKNLSQWERRSCRRLCHECGLKVEERRIETVSSCNC 315

  Fly   330 QFRWCCEVKCDECDESYEEFTC 351
            :|.|||.|||:.|.::...:.|
Zfish   316 KFHWCCTVKCETCTQTVTRYFC 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wnt2	NP_476810.1	wnt	36..352	CDD:278536	124/330 (38%)
wnt8a	NP_571021.3	WNT1	22..337	CDD:128408	123/328 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586713
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3913
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740