DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wnt2 and Wnt2b

DIOPT Version :9

Sequence 1:	NP_476810.1	Gene:	Wnt2 / 35975	FlyBaseID:	FBgn0004360	Length:	352	Species:	Drosophila melanogaster
Sequence 2:	NP_033546.2	Gene:	Wnt2b / 22414	MGIID:	1261834	Length:	389	Species:	Mus musculus

Alignment Length:	358	Identity:	149/358 - (41%)
Similarity:	217/358 - (60%)	Gaps:	34/358 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLIYILWIMEIRLVSSFTSV------MLCGRIPGLTPGQRNMCREMPDALIALGEGHQLGAQECQ 66
            ||:.:|..:..|:.:|:..:      ::|..||||...||.:|:..||.:.::|||.:...:|||
Mouse    42 LLLLLLLTLPARVDTSWWYIGALGARVICDNIPGLVSRQRQLCQRYPDIMRSVGEGAREWIRECQ 106

  Fly    67 HQFRGHRWNCSEV-WQRNVFAHVIPTASREAAYTYAIASAGAAYAVTAACARGNISTCGCDVRHK 130
            ||||.|||||:.: ....||...:..:|||||:.|||:|||..:|:|.||::|.:|.|.||
Mouse   107 HQFRHHRWNCTTLDRDHTVFGRAMLRSSREAAFVYAISSAGVVHAITRACSQGELSVCSCD---- 167

  Fly   131 ATP-TGGGTPDE--PWKWGGCSADVDFGMRYARRFMDARELE-RDSRTLMNLHNNRAGRTLVKKM 191
              | |.|...|:  .:.|||||.::.:|:|:|:.|:||:|.. :|:|.||||||||.|||.|::.
Mouse   168 --PYTRGRHHDQRGDFDWGGCSDNIHYGVRFAKAFVDAKEKRLKDARALMNLHNNRCGRTAVRRF 230

  Fly   192 LRTDCKCHGVSGSCVMKTCWKSLPPFRLVGDRLMLKYQKAKTVQAVKGKRGLRLVLSRK--KHAG 254
            |:.:||||||||||.::|||::|..||..||.|..:|..|  ||....:.|.....:|:  :||
Mouse   231 LKLECKCHGVSGSCTLRTCWRALSDFRRTGDYLRRRYDGA--VQVTATQDGANFTAARQGYRHA- 292

  Fly   255 TARAQKPVLDWPKRMELIYLEASPNYCERSLQTGSQGTSGRTCQRTGHGPQSCDLLCCGRGHNTQ 319
                        .|.:|:|.:.||:||......||.||:||.|.:|..|...|:::|||||::|.
Mouse   293 ------------TRTDLVYFDNSPDYCVLDKAAGSLGTAGRVCSKTSKGTDGCEIMCCGRGYDTT 345

  Fly   320 HIRRTTQCRCQFRWCCEVKCDECDESYEEFTCK 352
            .:.|.|||.|:|.|||.|:|.||..:.:..|||
Mouse   346 RVTRVTQCECKFHWCCAVRCKECRNTVDVHTCK 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wnt2	NP_476810.1	wnt	36..352	CDD:278536	138/322 (43%)
Wnt2b	NP_033546.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33
Wnt2b	NP_033546.2	wnt	72..378	CDD:306592	141/326 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842326
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3913
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42581
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X108
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740