Protein Alignment Camta and Camta2

DIOPT Version :10

• Sequence 1: NP_001137624.1
• Gene: Camta / 35974
• FlyBaseID: FBgn0287478
• Length: 2044
• Species: Drosophila melanogaster
• Sequence 2: XP_038941411.1
• Gene: Camta2 / 287462
• RGDID: 1311296
• Length: 1230
• Species: Rattus norvegicus
• Alignment Length: 1701
• Identity: 483/1701 - (28%)
• Similarity: 668/1701 - (39%)
• Gaps: 585/1701 - (34%)

  Fly   391 STTTQTNVPLGNDGEPIKLPDN-LESLPRADSFPSQRHRWNTNEEIAAILISFDKHGEWQSKEVR 454
            :|...|.|...:....|.||.. ||.|||....|.:|.|||||||||:.||:|:||.||.|...:
  Rat    25 NTKDTTEVAENSHHLKIFLPKKLLECLPRCPLLPPERLRWNTNEEIASYLITFEKHDEWLSCAPK 89

  Fly   455 TRPKSGSLLLYSRKKVRYRRDGYCWKKRKDGKTTREDHMKLKVQGTE-----CIYGCYVHSAILP 514
            |||::||::||:||||:||:|||.|||||||||||||||||||||.|     |:|||||||:|:|
  Rat    90 TRPQNGSIILYNRKKVKYRKDGYLWKKRKDGKTTREDHMKLKVQGMEPVSWQCLYGCYVHSSIVP 154

  Fly   515 TFHRRCYWLLQNPDIVLVHYLNVPYPDDNKMAVIAPSITLWGDKKEWTK---EELVSQLKPMLST 576
            ||||||||||||||||||||||||..:|..........::..|::||.|   |||:.|||||...
  Rat   155 TFHRRCYWLLQNPDIVLVHYLNVPALEDCGKGCSPIFCSISSDRREWLKWSREELLGQLKPMFHG 219

  Fly   577 INSDDDSDSGNDIEISTAETVESIVCQLMEKQRLSRQAALVKQLDC--GCGDGGCVDGKTCT-HP 638
            |.    ...||.:|   ..:||.:|.|:::... ::.|.......|  |.|.|......:.| |.
  Rat   220 IK----WSCGNGLE---EFSVEQLVQQILDTHP-TKPAPRTHACLCSGGLGSGSLTHKCSSTKHR 276

  Fly   639 VMR---RSAAMLKSSVQEKRLGEPFNGNTPNVVVASKLYSRWAERPRQHVDNHGQFHNVTQQLPQ 700
            ::.   ...|:..:|:...:..||     |.::....     .|.|:.|........:.:....:
  Rat   277 IISPKVEPRALTLASISHSKPPEP-----PPLIAPLP-----PELPKAHTSPSSSSSSSSSGFAE 331

  Fly   701 ESAIKFQIIPPQQQQQQDGNYQQQQYRGGSQMLAARSNLVMQQQQQHQQQQQYHQQQQQQQQQQQ 765
            ...|:     |.....:.|:     .|||:.:|....
  Rat   332 PLEIR-----PSPPTSRGGS-----SRGGTAILLLTG---------------------------- 358

  Fly   766 QHQQQQQHLSLQRFVASQGQNSVHLNQQHRLQIANTTITATASDPATTLAAAAAVAAASGATPVA 830
             .:|:...|:..|.:|||                        ::|...::.|..|.:...|.|
  Rat   359 -LEQRAGGLTPTRHLASQ------------------------AEPRPPVSLAVVVGSEPSAPP-- 396

  Fly   831 LNIMDTELIENQNHMTANKITNSGSSNSSSSNASKQLAGQTNNKLNVVNNNDPGNNNFMYNQQQQ 895
                                       :..|.|.                 ||  :.|:
  Rat   397 ---------------------------APPSPAF-----------------DP--DRFL------ 409

  Fly   896 LNASSNSNNSSQQQQQQQQQHYYKLQQTTATPTSGQPPPLAQVQPHSLAQPPVEAMCMSPEHRSS 960
                    ||.|:.|               |...||     .|.|.            .||...:
  Rat   410 --------NSPQRGQ---------------TYGGGQ-----GVNPD------------FPEAEGT 434

  Fly   961 SQPTPATSSAGSIPSSVSVSISVSTSTPTPAPTSISTPTSGTSSTSSSLQSIIDGNQQQQITTTS 1025
            ..|.||...|.::             .|..|...: .|.||.|....:...|.|.:..:::....
  Rat   435 HTPCPALEPAAAL-------------EPQAAARGL-PPQSGASGRRGNKFFIQDDDSGEELKGPG 485

  Fly  1026 TAATCDNLMSANALSEQDSHTVNNQATEAPNRSQLQSQSQSLSLNQNGCATYSASSDNSSQISDE 1090
            |.                      ....:|..|   |.|...:|..:|.||..
  Rat   486 TV----------------------PPVPSPPPS---SPSSPAALQPSGRATRG------------ 513

  Fly  1091 SSSFGGNNQNSSNSSTSEEEPQVEALSFFNETLDLSQEDIQRTLIANMPYNTTAAGATAPSTTIT 1155
            .:.|||     |..||||.||  .:||.|        .|:...||.:     .|.|..|||..::
  Rat   514 ETLFGG-----SAGSTSELEP--FSLSSF--------PDLMGELITD-----EAPGVPAPSPQLS 558

  Fly  1156 TGNTKLELSQQETKEKPAMGTETATEIEDDETDDVFANLDAFDMLVEFPELDLDDKQALNNTALE 1220
                            |.:.|
  Rat   559 ----------------PVLNT-------------------------------------------- 563

  Fly  1221 QSSFLGESAPSQPRKVHNICDFSPEWSYTEGGVKVLVAGPWTSSNGGAYTVLFDAQPVPTQLVQE 1285
                              |.||||||||.|||||||:.||||.: ...|:.:||...||..|||.
  Rat   564 ------------------ITDFSPEWSYPEGGVKVLITGPWTEA-AEHYSCVFDHIAVPASLVQP 609

  Fly  1286 GVLRCYCPAHEAGFVTLQVACGGFLVSNSVMFEYKLSLLADAP---FDATSSNDCLYKFTLLNRL 1347
            |||||||||||.|.|:||||.....:|.||:|||:.......|   .|..|.:|..::.::|.||
  Rat   610 GVLRCYCPAHEVGLVSLQVAGREGPLSASVLFEYRARRFLSLPSTQLDWLSLDDSQFRMSILERL 674

  Fly  1348 STIDEKL-----------------QVKTEHELTTDNTALYLEPNFEEKLVAYCHKLI-KHAWSMP 1394
            ..:::::                 .::.|.:          .|.||.::|.....:| :..|..|
  Rat   675 EQMEKRMAEIAAAGQAPGQGPEAPPIQDEGQ----------GPGFEARVVVLVESMIPRSTWRGP 729

  Fly  1395 STAASWTVGLRGMTLLHLAAALGYAKLVGAMLNWRS-ENPHIILETELDALSQDVYGFTPLAWAC 1458
            ......: ..|||:|||||||.|||:|:..:..||| |...:.||.|.|.|:.|.:..|||.|||
  Rat   730 ERLMHGS-PFRGMSLLHLAAAQGYARLIETLSQWRSVETGSLDLEQEADPLNVDHFSCTPLMWAC 793

  Fly  1459 VRGHVECSLLLYKWNHNALKIKTQAQQTPLDLASMRGHKVLLAQMYRLEKERCRKPQLRGGLANL 1523
            ..||:|.::||:.||..||.|.....:.||.:|..||| |.||        ||.:
  Rat   794 ALGHLEAAVLLFCWNRQALSIPDSLGRLPLSVAHSRGH-VRLA--------RCLE---------- 839

  Fly  1524 SMNMGVEAEAEEQHQSFSAFDLELQRKHDGVFLRPVAVH-SNQSPPNGSSRYSKRSSIDSGINMD 1587
                      |.|.|       ||..:|      |:|:. .:.||..|.|..|..|.:..|
  Rat   840 ----------ELQRQ-------ELSVEH------PLALSPQSSSPDTGLSSVSSPSELSDG---- 877

  Fly  1588 IRSKSGKPLARLHSNFESHDSYALGVD-SP-----------LDSLTGTNCLLS------PLRKMD 1634
                          .|....:|:...| ||           ::::.|.   ||      ||..||
  Rat   878 --------------TFSVTSAYSSAPDGSPPPAPMLASEISMETIPGQ---LSFGAPETPLLLMD 925

  Fly  1635 FALCEVSTGESSP--------VHDKDC--DDNSTSATDVTIGNDLVLPDAVVGDSDAKVLTLAEH 1689
            :.  ..::.||:|        ..|:..  |.:|..|.|       |:|        ..:::||:.
  Rat   926 YE--ATNSKESAPSPSGLPLAQDDRAAPEDADSPPAVD-------VIP--------VDMISLAKQ 973

  Fly  1690 IIAAMPERIKNE-ADEMMVLG-SPLTEPLT---SESSALTDSFMDPLLDSLPNTHFDSDFSFDFH 1749
            ||.|.|||||.| ..|:...| ||.....|   ||:.:...|:::. :|..|::.|.|:..|:
  Rat   974 IIEATPERIKREDFSELPEAGASPREHTGTVGLSETMSWLASYLEN-VDHFPSSAFPSELPFE-- 1035

  Fly  1750 DHSYRYHDVSTPCSSLSPASSGPLQSPASYSILGTDPSVSSPSPPPSTKQLTEFLHASSISSYPF 1814
                                                  ...|:.||: ....|||.||  :|...
  Rat  1036 --------------------------------------RGRPAIPPA-PSWAEFLSAS--TSGKM 1059

  Fly  1815 EADFSKLTLTDTEQRELYEAAKCIQKAYRSYKGRQKLEEQNKERSAATVIQNYYRRYKQ------ 1873
            |:||:.|||:|.|||||||||:.||.|:|.|||| :|:||  :..||.|||..||:|||
  Rat  1060 ESDFALLTLSDHEQRELYEAARVIQTAFRKYKGR-RLKEQ--QEVAAAVIQRCYRKYKQLTWIAL 1121

  Fly  1874 -YAYYRQMTNAALVIQHGYRSYRRNKRFKKSGLCLSSSSDHGSVSSNSQCLSSFYDHYKQDQQQL 1937
             :|.|::||.||::||..:|||...|||::|.........|             |..|::
  Rat  1122 KFALYKKMTQAAILIQSKFRSYYEQKRFQQSRRAAVLIQQH-------------YRSYRR----- 1168

  Fly  1938 HELGSQPSTPKETSPSGPL----KRTYSQSTQNQAARKIQQFMRQSRIKLQKERAEKEKLVHQRR 1998
                 :|..|..  |||||    |.|:....|:||||||.:|:|:.|              |:.|
  Rat  1169 -----RPGPPHR--PSGPLPSRNKGTFLTKKQDQAARKIMRFLRRCR--------------HRMR 1212

  Fly  1999 AEYLQNLQFQG 2009
             |..||.:.:|
  Rat  1213 -ELKQNQELEG 1222

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Camta	NP_001137624.1	CG-1	422..538	CDD:198144	89/120 (74%)
		TIG	1239..1319	CDD:460355	49/79 (62%)
		ANK repeat	1405..1447	CDD:293786	23/42 (55%)
		Ank_2	1410..1500	CDD:463710	43/90 (48%)
		ANK repeat	1449..1481	CDD:293786	16/31 (52%)
Camta2	XP_038941411.1	CG-1	57..178	CDD:198144	89/120 (74%)
		TIG	563..643	CDD:460355	50/142 (35%)
		ANKYR	<739..840	CDD:440430	51/129 (40%)
		ANK repeat	739..782	CDD:293786	23/42 (55%)
		PTZ00322	772..>911	CDD:140343	53/198 (27%)
		ANK repeat	784..816	CDD:293786	16/31 (52%)