DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Camta and CAMTA1

DIOPT Version :9

Sequence 1:	NP_001137624.1	Gene:	Camta / 35974	FlyBaseID:	FBgn0287478	Length:	2044	Species:	Drosophila melanogaster
Sequence 2:	XP_011539385.1	Gene:	CAMTA1 / 23261	HGNCID:	18806	Length:	1680	Species:	Homo sapiens

Alignment Length:	1868	Identity:	526/1868 - (28%)
Similarity:	781/1868 - (41%)	Gaps:	534/1868 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   406 PIKLPDNLESLPRADSFPSQRHRWNTNEEIAAILISFDKHGEWQSKEVRTRPKSGSLLLYSRKKV 470
            |.||   ||.||:..|.|.:||||||||||||.||:|:||.||.:...:|||::||::||:||||
Human    54 PKKL---LECLPKCSSLPKERHRWNTNEEIAAYLITFEKHEEWLTTSPKTRPQNGSMILYNRKKV 115

  Fly   471 RYRRDGYCWKKRKDGKTTREDHMKLKVQGTECIYGCYVHSAILPTFHRRCYWLLQNPDIVLVHYL 535
            :||:|||||||||||||||||||||||||.||:|||||||:|:||||||||||||||||||||||
Human   116 KYRKDGYCWKKRKDGKTTREDHMKLKVQGVECLYGCYVHSSIIPTFHRRCYWLLQNPDIVLVHYL 180

  Fly   536 NVPYPDD--NKMAVIAPSITLWGDKKE---WTKEELVSQLKPMLSTIN---SDDDSDSGNDIEIS 592
            |||..:|  .....|..||..  ||||   ||||||:.|||||...|.   |:.:|.||
Human   181 NVPAIEDCGKPCGPILCSINT--DKKEWAKWTKEELIGQLKPMFHGIKWTCSNGNSSSG------ 237

  Fly   593 TAETVESIVCQLMEKQRLSRQAALVKQLDCGC----GDGGCVDGKTCTHPVMRRSAAMLKSSVQE 653
              .:||.:|.|:::..:...|.   :..:|.|    |.||.|..| |.....|
Human   238 --FSVEQLVQQILDSHQTKPQP---RTHNCLCTGSLGAGGSVHHK-CNSAKHR------------ 284

  Fly   654 KRLGEPFNGNTPNVVVASKLYSRWAERPRQHVDNHGQFHNVTQQLPQESAIKFQIIPPQQQQQQD 718
                          :::.|:      .||  ...:|....|                 |.....:
Human   285 --------------IISPKV------EPR--TGGYGSHSEV-----------------QHNDVSE 310

  Fly   719 GNYQQQQYRGGSQMLAARSNLVMQQQQQHQQQQQYHQQQQQQQQQQQQHQQQQQHLSLQRFVASQ 783
            |.::....:|.|:  ..|:..|.:....|
Human   311 GKHEHSHSKGSSR--EKRNGKVAKPVLLH------------------------------------ 337

  Fly   784 GQNSVHLNQQHRLQIANTTITATAS-------------DPATTLAAAAAVAAASGATPVALNIMD 835
             |:|..::..:::::.:||.::..|             .|..|..:..|||:..|:...:..:..
Human   338 -QSSTEVSSTNQVEVPDTTQSSPVSISSGLNSDPDMVDSPVVTGVSGMAVASVMGSLSQSATVFM 401

  Fly   836 TEL------------------------------IENQNHMTANKITNSGSSNSSS---SNASKQL 867
            :|:                              :.:..|..|  ...:|||.|.|   :|.|::|
Human   402 SEVTNEAVYTMSPTAGPNHHLLSPDASQGLVLAVSSDGHKFA--FPTTGSSESLSMLPTNVSEEL 464

  Fly   868 AGQT----NNKL-NVVNNNDPGNNNFMYNQQQQLNASSNSNNSSQQQQQQQQQHYYKLQQTTATP 927
            ...|    ..|: ....|.||  :.|:             ||..|.|
Human   465 VLSTTLDGGRKIPETTMNFDP--DCFL-------------NNPKQGQ------------------ 496

  Fly   928 TSGQPPPLAQVQPHSLAQPPVEAMCMSPEHRSSSQPTPATSS------------AGSIPSSVSVS 980
            |.|.....|::...::...|       |..||.|..|..|..            |....||.:.:
Human   497 TYGGGGLKAEMVSSNIRHSP-------PGERSFSFTTVLTKEIKTEDTSFEQQMAKEAYSSSAAA 554

  Fly   981 ISVSTSTPTPAPTSISTPTSGTSSTSSSLQ----SIIDGNQQQQITTTSTAATCDNLMSANALSE 1041
            ::.|:.|.|...:.:  |:.|..|.|::|:    |.||.|:..    ||:.:
Human   555 VAASSLTLTAGSSLL--PSGGGLSPSTTLEQMDFSAIDSNKDY----TSSFS------------- 600

  Fly  1042 QDSHTVNNQATEAPNRSQLQSQSQSLSLNQNGCATYSASSDN---------SSQISDESSSFGGN 1097
            |..|:.:...|.:|: ..||..|:.|.:.||   |:|:.||:         .::.|.::||..|:
Human   601 QTGHSPHIHQTPSPS-FFLQDASKPLPVEQN---THSSLSDSGGTFVMPTVKTEASSQTSSCSGH 661

  Fly  1098 NQNSSNSSTS----EEEPQVEALSFFNE-TLDLSQ-EDIQRTLIAN-----------MPYNTTAA 1145
            .:....|::|    :.:...:|::...| |::.|| .:....|:.:           :...|...
Human   662 VETRIESTSSLHLMQFQANFQAMTAEGEVTMETSQAAEGSEVLLKSGELQACSSEHYLQPETNGV 726

  Fly  1146 GATAPSTTITTGNTKLELSQQETKEKPAMGTETATEIEDDETDDVFANLDAFDMLVEFPELD--- 1207
            ..:|....|..||....|   ....:|::|..:..|:..|..|..|:| ...|::.:|..::
Human   727 IRSAGGVPILPGNVVQGL---YPVAQPSLGNASNMELSLDHFDISFSN-QFSDLINDFISVEGGS 787

  Fly  1208 --LDDKQAL--NNTALEQSSFLGESAP-------------------------------------- 1230
              :...|.:  ::|||.||.. |..||
Human   788 STIYGHQLVSGDSTALSQSED-GARAPFTQAEMCLPCCSPQQGSLQLSSSEGGASTMAYMHVAEV 851

  Fly  1231 -------------SQPRKVHNICDFSPEWSYTEGGVKVLVAGPWTSSNGGAYTVLFDAQPVPTQL 1282
                         .|..:|..:.|:||||||.|||||||:.|||..::.. |:.|||...||..|
Human   852 VSAASAQGTLGMLQQSGRVFMVTDYSPEWSYPEGGVKVLITGPWQEASNN-YSCLFDQISVPASL 915

  Fly  1283 VQEGVLRCYCPAHEAGFVTLQVACGGFLVSNSVMFEYK---LSLLADAPFDATSSNDCLYKFTLL 1344
            :|.||||||||||:.|.||||||....::||||:||||   |..|..:..|..|.:|..::.::|
Human   916 IQPGVLRCYCPAHDTGLVTLQVAFNNQIISNSVVFEYKARALPTLPSSQHDWLSLDDNQFRMSIL 980

  Fly  1345 NRLSTIDEKLQVKT---EHELTTDNTAL--------------------YLEPNFEEKLVAYCHKL 1386
            .||..::.::...|   :|:..:...:.                    .|...||.::|..|.|:
Human   981 ERLEQMERRMAEMTGSQQHKQASGGGSSGGGSGSGNGGSQAQCASGTGALGSCFESRVVVVCEKM 1045

  Fly  1387 IKHAWSMPSTAASWTVGLRGMTLLHLAAALGYAKLVGAMLNWRSENPHII-LETELDALSQDVYG 1450
            :..|....|.....:...|||||||||||.|||.|:..::.||:::...| ||.|:|.|:.|.:.
Human  1046 MSRACWAKSKHLIHSKTFRGMTLLHLAAAQGYATLIQTLIKWRTKHADSIDLELEVDPLNVDHFS 1110

  Fly  1451 FTPLAWACVRGHVECSLLLYKWNHNALKIKTQAQQTPLDLASMRGHKVLLAQ------------- 1502
            .|||.|||..||:|.:::||||:..|:.|.....:.||.:|..||| |.||:
Human  1111 CTPLMWACALGHLEAAVVLYKWDRRAISIPDSLGRLPLGIARSRGH-VKLAECLEHLQRDEQAQL 1174

  Fly  1503 -------------------MYRLEKERCRKPQLRGGLANL-SMNMGV---EAEAEEQHQSFSAFD 1544
                               |.:...|....|::..|:..: |.|..:   .:|....:.|.|..|
Human  1175 GQNPRIHCPASEEPSTESWMAQWHSEAISSPEIPKGVTVIASTNPELRRPRSEPSNYYSSESHKD 1239

  Fly  1545 LELQRKHDGVFLRPVAVHSNQ------------------------------SPPNGSSRYSKRSS 1579
            ....:||.   |.|....:.|                              ||..|...:|:..|
Human  1240 YPAPKKHK---LNPEYFQTRQEKLLPTALSLEEPNIRKQSPSSKQSVPETLSPSEGVRDFSRELS 1301

  Fly  1580 IDSGINMDIRSKSGKPLARLHSNFESHDSYALGVD------SPLDSLTGTNCLLS------PLRK 1632
            ..:......::...:|:.:    :.|.|.| :||.      :|..:..|.....|      |:..
Human  1302 PPTPETAAFQASGSQPVGK----WNSKDLY-IGVSTVQVTGNPKGTSVGKEAAPSQVRPREPMSV 1361

  Fly  1633 MDFALCEVSTGESSPVHDKDCDDNSTSATDVTIGNDLVLPDAVVGDSDAKVLTLAEHIIAAMPER 1697
            :..|..||...|.....|        ||.:...|..:       .|....::|||||||.|.|:|
Human  1362 LMMANREVVNTELGSYRD--------SAENEECGQPM-------DDIQVNMMTLAEHIIEATPDR 1411

  Fly  1698 IKNE-ADEMMVLGSPLTEPLTSES------SALTDSFMDPLLDSLPNTHFDSDFSFDFHDHSYRY 1755
            ||.| ...|...|...|:|.|..|      |.|.|:      |.||:.          ......|
Human  1412 IKQENFVPMESSGLERTDPATISSTMSWLASYLADA------DCLPSA----------AQIRSAY 1460

  Fly  1756 HDVSTPCSSLSPASSGPLQSPASYSILGTDPSVSSPSPPPSTKQLTEFLHASSISSYPFEADFSK 1820
            ::..||.|:   .|..|:.||.| .|....|::      ||....:|||.||  :|...|.:|::
Human  1461 NEPLTPSSN---TSLSPVGSPVS-EIAFEKPNL------PSAADWSEFLSAS--TSEKVENEFAQ 1513

  Fly  1821 LTLTDTEQRELYEAAKCIQKAYRSYKGRQKLEEQNKERSAATVIQNYYRRYKQ-------YAYYR 1878
            |||:|.|||||||||:.:|.|:|.||||...|:|   ..||.|||..||:|||       ||.|:
Human  1514 LTLSDHEQRELYEAARLVQTAFRKYKGRPLREQQ---EVAAAVIQRCYRKYKQLTWIALKYALYK 1575

  Fly  1879 QMTNAALVIQHGYRSYRRNKRFKKSGLCLSSSSDHGSVSSNSQCLSSFYDHYKQDQQQLHELGSQ 1943
            :||.||::||..:|||...|:|::|             ...:..:..:|..||:..::.....:.
Human  1576 KMTQAAILIQSKFRSYYEQKKFQQS-------------RRAAVLIQKYYRSYKKCGKRRQARRTA 1627

  Fly  1944 PSTPKETSPSGPLKRTYSQSTQNQAARKIQQFMRQSRIKLQKERAEKE 1991
            ....::      |:.:.....|:||||||.:|:|:.|.::::.:..||
Human  1628 VIVQQK------LRSSLLTKKQDQAARKIMRFLRRCRHRVKELKKAKE 1669

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Camta	NP_001137624.1	CG-1	422..538	CDD:198144	91/115 (79%)
		TIG	1242..1319	CDD:280079	46/76 (61%)
		ANK	<1405..1497	CDD:238125	44/92 (48%)
		ANK repeat	1405..1447	CDD:293786	23/42 (55%)
		Ank_2	1410..1500	CDD:289560	41/90 (46%)
		ANK repeat	1449..1481	CDD:293786	15/31 (48%)
CAMTA1	XP_011539385.1	CG-1	67..183	CDD:198144	91/115 (79%)
		TIG	873..952	CDD:280079	47/79 (59%)
		ANK repeat	1064..1107	CDD:293786	23/42 (55%)
		ANK	1065..1186	CDD:238125	47/121 (39%)
		Ank_4	1065..1129	CDD:290365	32/63 (51%)
		ANK repeat	1109..1141	CDD:293786	15/31 (48%)
		Ank_4	1112..1163	CDD:290365	24/51 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	213	1.000	Domainoid score	I2752
eggNOG	1	0.900	-	-		E1_KOG0520
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	594	1.000	Inparanoid score	I978
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D161424at33208
OrthoFinder	1	1.000	-	-		FOG0001351
OrthoInspector	1	1.000	-	-		otm40302
orthoMCL	1	0.900	-	-		OOG6_105843
Panther	1	1.100	-	-	LDO	PTHR23335
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3337
SonicParanoid	1	1.000	-	-		X1066
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.950