DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Camta and Camta2

DIOPT Version :9

Sequence 1:	NP_001137624.1	Gene:	Camta / 35974	FlyBaseID:	FBgn0287478	Length:	2044	Species:	Drosophila melanogaster
Sequence 2:	XP_006532981.1	Gene:	Camta2 / 216874	MGIID:	2135957	Length:	1272	Species:	Mus musculus

Alignment Length:	1752	Identity:	488/1752 - (27%)
Similarity:	677/1752 - (38%)	Gaps:	590/1752 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   327 ATSSTATTILRLGKSATTVAINGASKLEATTSTTTAVPV-------PATATTSNKLSNAVTSEQQ 384
            |:||:...:.|....|...|:.|     ..|.:.:..|:       |.|.|.:.|.:..|.....
Mouse    19 ASSSSHLFLKRAEAQAGARAVEG-----ICTDSPSPRPLRPGVTWPPGTFTMNTKDTTEVAENSH 78

  Fly   385 QQQQQQSTTTQTNVPLGNDGEPIKLPDN-LESLPRADSFPSQRHRWNTNEEIAAILISFDKHGEW 448
            ..:                   |.||.. ||.|||....|.:|.|||||||||:.||:|:||.||
Mouse    79 HLK-------------------IFLPKKLLECLPRCPLLPPERLRWNTNEEIASYLITFEKHDEW 124

  Fly   449 QSKEVRTRPKSGSLLLYSRKKVRYRRDGYCWKKRKDGKTTREDHMKLKVQGTE-----CIYGCYV 508
            .|...:|||::||::||:||||:||:|||.|||||||||||||||||||||.|     |:|||||
Mouse   125 LSCAPKTRPQNGSIILYNRKKVKYRKDGYLWKKRKDGKTTREDHMKLKVQGMEPVSWQCLYGCYV 189

  Fly   509 HSAILPTFHRRCYWLLQNPDIVLVHYLNVPYPDDNKMAVIAPSITLWGDKKEWTK---EELVSQL 570
            ||:|:|||||||||||||||||||||||||..:|..........::..|::||.|   |||:.||
Mouse   190 HSSIVPTFHRRCYWLLQNPDIVLVHYLNVPALEDCGKGCSPIFCSISSDRREWLKWSREELLGQL 254

  Fly   571 KPMLSTINSDDDSDSGNDIEISTAETVESIVCQLMEKQRLSRQAALVKQLDCGCGDGGCVDGKTC 635
            |||...|.    ...||..|   ..:||.:|.|:::
Mouse   255 KPMFHGIK----WSCGNGAE---EFSVEQLVQQILD----------------------------- 283

  Fly   636 THPVMRRSAAMLKSSVQEKRLGEPFNGNTPNVVVASKLYSRWAERPRQHVDNHGQFHNVTQQLPQ 700
            |||.                  :|                    .||.|.
Mouse   284 THPT------------------KP--------------------APRTHA--------------- 295

  Fly   701 ESAIKFQIIPPQQQQQQDGNYQQQQYRGGSQMLAARSNLVMQQQQQHQQQQQYHQQQQQQQQQQQ 765

Mouse   296 ----------------------------------------------------------------- 295

  Fly   766 QHQQQQQHLSLQRFVASQGQNSVHLNQQHRLQIANTTITATASDPATTLAAAAAVAAASGATPVA 830
                         .:.|.|..|..|.  |:.......|.:...:| ..||.|:...:.....|..
Mouse   296 -------------CLCSGGLGSGSLT--HKCSSTKHRIISPKVEP-RALALASISHSKPPEPPPL 344

  Fly   831 LNIMDTELIENQNHMTANKITNSGSSNSSSSNASKQLAGQTNNKLNVVNNNDPGNNNFMYNQQQQ 895
            :..:..||.:      |:...:|.||:||||..::.|.         :..:.|.:.
Mouse   345 IAPLPPELPK------AHTSPSSSSSSSSSSGFAEPLE---------IRPSPPTSR--------- 385

  Fly   896 LNASSNSNNSSQQQQQQQQQHYYKLQQTTATPTSGQPPPLAQVQPHSLAQPPVEAMCMSPEHRSS 960
             ..||....:.             |..|.....:|...|...:.|.:..:|||
Mouse   386 -GGSSRGGTAI-------------LLLTGLEQRAGGLTPTRHLAPQAEPRPPV------------ 424

  Fly   961 SQPTPATSSAGSIPSSVSVSISVSTSTPTPAPTS--------ISTPTSGTSSTSSSLQSIIDGNQ 1017
                           |::|.:....|.| |||.|        :::|..|  .|....|.:.....
Mouse   425 ---------------SLAVVVGSEPSAP-PAPPSPAFDPDRFLNSPQRG--QTYGGGQGVNPDFP 471

  Fly  1018 QQQITTTSTAATCDNLMSANALSEQDSHTVNNQATEAPNRSQLQSQSQSLSLNQNGCATYSASSD 1082
            :.:.|.|    .|..|..|.||..|                                   :|:..
Mouse   472 EAEGTHT----PCPALEPAAALEPQ-----------------------------------AAARG 497

  Fly  1083 NSSQISDESSSFGGNNQNSSNSSTSEEEPQVEALSFFNETLDLSQEDIQRTLIANMPYNTTAAGA 1147
            .:.|:       |.|.:..:              .||.:..|..:|       ...|.......:
Mouse   498 LAPQL-------GANGRRGN--------------KFFIQDDDSGEE-------LKGPGTVPPVPS 534

  Fly  1148 TAPSTTITTGNTKLELSQQETKEKPAMGTETATEIEDDETDDVFANLDAFDMLVEFPELDLDDKQ 1212
            :.||:  .:..|.|..|.:.|:.:...|....:..|          |:.|. |..||:|
Mouse   535 SPPSS--PSSPTALPPSGRATRGEALFGGSAGSSSE----------LEPFS-LSSFPDL------ 580

  Fly  1213 ALNNTALEQSSFLGESAPSQPR-------KVHNICDFSPEWSYTEGGVKVLVAGPWTSSNGGAYT 1270
                    ....:.:.||..|.       .::.|.||||||||.|||||||:.||||.: ...|:
Mouse   581 --------MGELISDEAPGVPAPAPQLSPALNAITDFSPEWSYPEGGVKVLITGPWTEA-AEHYS 636

  Fly  1271 VLFDAQPVPTQLVQEGVLRCYCPAHEAGFVTLQVACGGFLVSNSVMFEYKLSLLADAP---FDAT 1332
            .:||...||..|||.|||||||||||.|.|:||||.....:|.||:|||:.......|   .|..
Mouse   637 CVFDHIAVPASLVQPGVLRCYCPAHEVGLVSLQVAGREGPLSASVLFEYRARRFLSLPSTQLDWL 701

  Fly  1333 SSNDCLYKFTLLNRLSTIDEKL-----------------QVKTEHELTTDNTALYLEPNFEEKLV 1380
            |.:|..::.::|.||..:::::                 .::.|.:          .|.||.::|
Mouse   702 SLDDSQFRMSILERLEQMEKRMAEIAAAGQAPGQGPEAPPIQDEGQ----------GPGFEARVV 756

  Fly  1381 AYCHKLI-KHAWSMPSTAASWTVGLRGMTLLHLAAALGYAKLVGAMLNWRS-ENPHIILETELDA 1443
            .....:| :..|..|......: ..|||:|||||||.|||:|:..:..||| |...:.||.|:|.
Mouse   757 VLVESMIPRSTWRGPERLIHGS-PFRGMSLLHLAAAQGYARLIETLSQWRSVETGSLDLEQEVDP 820

  Fly  1444 LSQDVYGFTPLAWACVRGHVECSLLLYKWNHNALKIKTQAQQTPLDLASMRGHKVLLAQMYRLEK 1508
            |:.|.:..|||.|||..||:|.::||:.||..||.|.....:.||.:|..||| |.||
Mouse   821 LNVDHFSCTPLMWACALGHLEAAVLLFCWNRQALSIPDSLGRLPLSVAHSRGH-VRLA------- 877

  Fly  1509 ERCRKPQLRGGLANLSMNMGVEAEAEEQHQSFSAFDLELQRKHDGVFLRPVAVHSNQSPPNGSSR 1573
             ||.:                    |.|.|       ||..:|      |:|:    |||:
Mouse   878 -RCLE--------------------ELQRQ-------ELSVEH------PLAL----SPPS---- 900

  Fly  1574 YSKRSSIDSGINMDIRSKSGKPLARLHSNFESHDSYA------------LGVDSPLDSLTG-TNC 1625
                ||.|:|:     |.:..|.......|....:|:            |..|..::.:.| .:|
Mouse   901 ----SSPDTGL-----SSASSPSELSDGTFSVTSAYSSAPDGSPPPAPPLASDISMEMIPGQLSC 956

  Fly  1626 LL--SPLRKMDFALCEVSTGESSPVHDKDCDDNSTSATDVTIGNDLVLPDAVVGDSD---AKVLT 1685
            ..  :||..||:..........||.......||..:..|..      .|.||    |   ..:::
Mouse   957 GAPETPLLLMDYEATNSKEPAPSPCGPPLAQDNGAAPEDAD------SPPAV----DVIPVDMIS 1011

  Fly  1686 LAEHIIAAMPERIKNE-ADEMMVLGSPLTEPLTSESSALTDSFMDPLLDSLPNTHFDSDFSFDFH 1749
            ||:.||.|.|||||.| ..|....|:...|...:...:.|.|::...|:::  .||.|
Mouse  1012 LAKQIIDATPERIKREDFSEFPDAGASPREHTGTVGLSETMSWLASYLENV--DHFPS------- 1067

  Fly  1750 DHSYRYHDVSTPCSSLSPASSGPLQSPASYSILGTDPSVSSPSPPPSTKQLTEFLHASSISSYPF 1814
                     |.|.|.| |...|.|..|                |.||   ..|||.||  :|...
Mouse  1068 ---------SAPPSEL-PFERGRLAIP----------------PAPS---WAEFLSAS--TSGKM 1101

  Fly  1815 EADFSKLTLTDTEQRELYEAAKCIQKAYRSYKGRQKLEEQNKERSAATVIQNYYRRYKQ------ 1873
            |:||:.|||:|.|||||||||:.||.|:|.|||| :|:||  :..||.|||..||:|||
Mouse  1102 ESDFALLTLSDHEQRELYEAARVIQTAFRKYKGR-RLKEQ--QEVAAAVIQRCYRKYKQLTWIAL 1163

  Fly  1874 -YAYYRQMTNAALVIQHGYRSYRRNKRFKKSGLCLSSSSDHGSVSSNSQCLSSFYDHYKQDQQQL 1937
             :|.|::||.||::||..:|||...|||::|.........|             |..|::
Mouse  1164 KFALYKKMTQAAILIQSKFRSYYEQKRFQQSRRAAVLIQQH-------------YRSYRR----- 1210

  Fly  1938 HELGSQPSTPKETSPSGPL----KRTYSQSTQNQAARKIQQFMRQSRIKLQ--KERAEKEKL 1993
                 :|..|..  |||||    |.|:....|:||||||.:|:|:.|.:::  |:..|.|.|
Mouse  1211 -----RPGPPHR--PSGPLPARNKGTFLTKKQDQAARKIMRFLRRCRHRMRELKQNQELEGL 1265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Camta	NP_001137624.1	CG-1	422..538	CDD:198144	89/120 (74%)
		TIG	1242..1319	CDD:280079	47/76 (62%)
		ANK	<1405..1497	CDD:238125	45/92 (49%)
		ANK repeat	1405..1447	CDD:293786	23/42 (55%)
		Ank_2	1410..1500	CDD:289560	43/90 (48%)
		ANK repeat	1449..1481	CDD:293786	16/31 (52%)
Camta2	XP_006532981.1	CG-1	98..219	CDD:198144	89/120 (74%)
		TIG	606..685	CDD:366832	49/79 (62%)
		ANK repeat	781..824	CDD:293786	23/42 (55%)
		Ank_2	786..880	CDD:372319	46/102 (45%)
		ANK repeat	826..858	CDD:293786	16/31 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	213	1.000	Domainoid score	I2740
eggNOG	1	0.900	-	-		E1_KOG0520
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	591	1.000	Inparanoid score	I981
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D161424at33208
OrthoFinder	1	1.000	-	-		FOG0001351
OrthoInspector	1	1.000	-	-		otm42367
orthoMCL	1	0.900	-	-		OOG6_105843
Panther	1	1.100	-	-	O	PTHR23335
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3337
SonicParanoid	1	1.000	-	-		X1066
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.860