DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Camta and Camta1

DIOPT Version :9

Sequence 1:	NP_001137624.1	Gene:	Camta / 35974	FlyBaseID:	FBgn0287478	Length:	2044	Species:	Drosophila melanogaster
Sequence 2:	NP_001075026.1	Gene:	Camta1 / 100072	MGIID:	2140230	Length:	1682	Species:	Mus musculus

Alignment Length:	1878	Identity:	528/1878 - (28%)
Similarity:	789/1878 - (42%)	Gaps:	546/1878 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   406 PIKLPDNLESLPRADSFPSQRHRWNTNEEIAAILISFDKHGEWQSKEVRTRPKSGSLLLYSRKKV 470
            |.||   ||.||:..|.|.:||||||||||||.||:|:||.||.:...:|||::||::||:||||
Mouse    54 PKKL---LECLPKCSSLPKERHRWNTNEEIAAYLITFEKHEEWLTTSPKTRPQNGSMILYNRKKV 115

  Fly   471 RYRRDGYCWKKRKDGKTTREDHMKLKVQGTECIYGCYVHSAILPTFHRRCYWLLQNPDIVLVHYL 535
            :||:|||||||||||||||||||||||||.||:|||||||:|:||||||||||||||||||||||
Mouse   116 KYRKDGYCWKKRKDGKTTREDHMKLKVQGVECLYGCYVHSSIIPTFHRRCYWLLQNPDIVLVHYL 180

  Fly   536 NVPYPDD--NKMAVIAPSITLWGDKKE---WTKEELVSQLKPMLSTIN---SDDDSDSGNDIEIS 592
            |||..:|  .....|..||..  ||||   ||||||:.|||||...|.   |:.:|.||
Mouse   181 NVPAIEDCGKPCGPILCSINT--DKKEWAKWTKEELIGQLKPMFHGIKWTCSNGNSSSG------ 237

  Fly   593 TAETVESIVCQLMEKQRLSRQAALVKQLDCGCGDGGCVDGKTCTHPVMRRSAAMLKSSVQEKRLG 657
              .:||.:|.|:::..:...|..                    ||..:...:....|||..|.
Mouse   238 --FSVEQLVQQILDSHQTKPQPR--------------------THNCLCTGSLGAGSSVHHKC-- 278

  Fly   658 EPFNGNTPNVVVASKLYSRWAERPRQHVDNHGQFHNVTQQLPQESAIKFQIIPPQQQQQQDGNYQ 722
                                                        ::.|.:||.|:.:.:..|
Mouse   279 --------------------------------------------NSAKHRIISPKVEPRAGG--- 296

  Fly   723 QQQYRGGSQMLAARSNLVMQQQQQHQQQQQYHQQQQQQQQQQQQHQQQQQHLSLQRFVASQGQNS 787
               |.|.|::            |.:...:..|:....:...:::...:....:|..      |||
Mouse   297 ---YGGHSEV------------QHNDVSEGKHEPSHGRSTSREKRNGKVAKPALLH------QNS 340

  Fly   788 VHLNQQHRLQIANTTITATAS-------------DPATTLAAAAAVAAASGATPVALNIMDTEL- 838
            ..::..:::::.:||.::..|             .|..|..::.|||:..|....:..:..:|:
Mouse   341 TEVSSTNQVEVPDTTQSSPVSISSGLNSDPDMVDSPVVTGVSSMAVASVMGGLSQSATVFMSEVT 405

  Fly   839 -----------------------------IENQNHMTANKITNSGSSNSSS---SNASKQLAGQT 871
                                         :.:..|..|  ...:|||:|.|   :|.|::|...|
Mouse   406 NEAVYTMSPTAGPNHHLLSPDASQGLVLAVSSDGHKFA--FPTTGSSDSLSMLPANVSEELVLST 468

  Fly   872 ----NNKL-NVVNNNDPGNNNFMYNQQQQLNASSNSNNSSQQQQQQQQQHYYKLQQTTATPTSGQ 931
                ..|: ....|.||  :.|:.|.:|..........:                :..:|.....
Mouse   469 TLDGGRKIPETAMNFDP--DCFLNNPKQGQTYGGGGLKA----------------EMVSTNIRHS 515

  Fly   932 PPPLAQVQPHSLAQPPVEAMCMSPEHRSSSQPTPATSSAGSIPSSVSVSISVSTSTPTPAPTSIS 996
            ||........|:....::....|.|.:.:.:...::|:|.:..||:         |.|.|.:|:
Mouse   516 PPAERSFGFTSVLTKEIKTEDTSFEQQMAKEAAYSSSAAAAASSSL---------TLTAAGSSL- 570

  Fly   997 TPTSGTSSTSSSLQ----SIIDGNQQQQITTTSTAATCDNLMSANALSEQDSHTVNNQATEAPNR 1057
            .|:.|..|.|::|:    |.||.|:..                |::.| |..|:.:...|.:|:
Mouse   571 LPSGGGLSPSTTLEQMDFSAIDSNKDY----------------ASSFS-QTGHSPHIHQTPSPS- 617

  Fly  1058 SQLQSQSQSLSLNQNGCATYSASSDNSS-----QISDESSSFGGNNQNSSNSSTSEEEPQVEALS 1117
            ..||..|:.|.|.||   |:|:.|::.:     .:..|:||       .::|.:...|.::|:.|
Mouse   618 FFLQDASKPLPLEQN---THSSLSESGAAFVMPTVKTEASS-------QTSSCSGHVETRIESTS 672

  Fly  1118 FFNETLDLSQEDIQRTLIANMPYNTTAAGATAPSTTITTGNTKL----ELS--------QQETK- 1169
                :|.|.|      ..||..........|..::....||..|    ||.        |.||.
Mouse   673 ----SLHLMQ------FQANFQAMAAEGEVTMETSQAAEGNEVLLKSGELQACGSEHYLQPETNG 727

  Fly  1170 ----------------------EKPAMGTETATEIEDDETDDVFANLDAFDMLVEF--------- 1203
                                  .:|::|..:..|:..|..|..|:| ...|::.:|
Mouse   728 VIRSAGGVPLLPSNVVQGLYPVAQPSLGNSSNMELSLDHFDISFSN-QFSDLINDFISVEGGSGT 791

  Fly  1204 ---PELDLDDKQALNNT-----------------------ALEQSSFLGESAPS----------- 1231
               .:|...|..||:.:                       :|:.||  .|..||
Mouse   792 IYGHQLVSGDSAALSQSEDGARAPFTQAEMCIPCCSPQQGSLQLSS--AEGGPSTMAYMHVAEVV 854

  Fly  1232 -------------QPRKVHNICDFSPEWSYTEGGVKVLVAGPWTSSNGGAYTVLFDAQPVPTQLV 1283
                         |..:|..:.|:||||||.|||||||:.|||..::.. |:.|||...||..|:
Mouse   855 SAASAQGALGMLQQSGRVFMVTDYSPEWSYPEGGVKVLITGPWQEASNN-YSCLFDQISVPASLI 918

  Fly  1284 QEGVLRCYCPAHEAGFVTLQVACGGFLVSNSVMFEYK---LSLLADAPFDATSSNDCLYKFTLLN 1345
            |.||||||||||:.|.||||||....::||||:||||   |..|..:..|..|.:|..::.::|.
Mouse   919 QPGVLRCYCPAHDTGLVTLQVAFNNQIISNSVVFEYKARALPTLPSSQHDWLSLDDNQFRMSILE 983

  Fly  1346 RLSTIDEKLQVKT---EHELTTD--------------------NTALYLEPNFEEKLVAYCHKLI 1387
            ||..::.::...|   :|:..:.                    :.|..|...||.::|..|.|::
Mouse   984 RLEQMERRMAEMTGSQQHKQASGGGGSGSGSGSGAGGGQAQCASGAGTLGSCFESRVVVVCEKMM 1048

  Fly  1388 KHAWSMPSTAASWTVGLRGMTLLHLAAALGYAKLVGAMLNWRSENPHII-LETELDALSQDVYGF 1451
            ..|....|.....:...|||||||||||.|||.|:..::.||:::...| ||.|:|.|:.|.:..
Mouse  1049 SRACWAKSKHLIHSKTFRGMTLLHLAAAQGYATLIQTLIKWRTKHADSIDLELEVDPLNVDHFSC 1113

  Fly  1452 TPLAWACVRGHVECSLLLYKWNHNALKIKTQAQQTPLDLASMRGHKVLLAQ-------------- 1502
            |||.|||..||:|.:::||||:..|:.|.....:.||.:|..||| |.||:
Mouse  1114 TPLMWACALGHLEAAVVLYKWDRRAISIPDSLGRLPLGIARSRGH-VKLAECLEHLQRDEQAQLG 1177

  Fly  1503 ------------------MYRLEKERCRKPQLRGGLANL-SMNMGVEAEAEEQHQSFSA---FDL 1545
                              |.:.::|....|::..|:..: |.|..:.....|....:|.   .|.
Mouse  1178 QASRIHCAPSEEPTTDSWMAQWQREAMSPPEIPKGVTVIASTNPELRRPRSEPSNYYSTEGHKDY 1242

  Fly  1546 ELQRKHDGVFLRPVAVHSNQ------------------------------SPPNGSSRYSKRSSI 1580
            ...:||.   |.|.:..:.|                              ||..|...||:.::.
Mouse  1243 PAPKKHK---LNPESFQARQEKLLCTALSLEQPNIRKQSPRSKQPSPETISPSEGVREYSREAAP 1304

  Fly  1581 DSGINMDIRSKSGKPLARLHSNFESHDSYALGVDS--PLDSLTGTNCL----------LSPLRKM 1633
            .:......::.:.:|:.:    :.:.|.| :||.:  ...:..||:.:          ..|:..:
Mouse  1305 PTPETAASQASASQPVVK----WSAKDLY-IGVSTVQVTGNPKGTSVVKDAAPSQVRPREPMSVL 1364

  Fly  1634 DFALCEVSTGESSPVHDKDCDDNSTSATDVTIGNDLVLPDAVVGDSDAKVLTLAEHIIAAMPERI 1698
            ..|..||...|.....|:...::.....|               |....::|||||||.|.|:||
Mouse  1365 MLANREVVNTEMGAYRDRTEHEDCPQPMD---------------DIQVNMMTLAEHIIEATPDRI 1414

  Fly  1699 KNEADEMMVLGSPL--TEPLTSES------SALTDSFMDPLLDSLPN-THFDSDFSFDFHDHSYR 1754
            |.| :.:.:..|.|  |:|.|..|      |.|.|:      |.||: .|..|           .
Mouse  1415 KQE-NFVPMESSALERTDPATISSTMSWLASYLADA------DRLPSAAHIRS-----------A 1461

  Fly  1755 YHDVSTPCS--SLSPASSGPLQSPASYSILGTDPSVSSPSPPPSTKQLTEFLHASSISSYPFEAD 1817
            |.:..||.|  |||||.     ||.| .:....||:      ||....:|||.||  :|...|::
Mouse  1462 YTEPLTPSSNASLSPAG-----SPVS-EVAFEKPSL------PSAADWSEFLSAS--TSEKVESE 1512

  Fly  1818 FSKLTLTDTEQRELYEAAKCIQKAYRSYKGRQKLEEQNKERSAATVIQNYYRRYKQ-------YA 1875
            .::|||:|.|||||||||:.:|.|:|.||||...|:|   ..||.|||..||:|||       ||
Mouse  1513 LAQLTLSDHEQRELYEAARLVQTAFRKYKGRPLREQQ---EVAAAVIQRCYRKYKQLTWIALKYA 1574

  Fly  1876 YYRQMTNAALVIQHGYRSYRRNKRFKKSGLCLSSSSDHGSVSSNSQCLSSFYDHYKQDQQQLHEL 1940
            .|::||.||::||..:|||...|||::|             ...:..:.:||..||:..::
Mouse  1575 LYKKMTQAAILIQSKFRSYYEQKRFQQS-------------RRAAVLIQNFYRSYKKCGRR---- 1622

  Fly  1941 GSQPSTPKETSPSGPLKRTYSQSTQNQAARKIQQFMRQ--------SRIKLQKERAEK 1990
              :|:..........|:.:.....|:||||||.:|:|:        .|:..:.||.||
Mouse  1623 --RPARRTAVIVQQKLRSSLLTKKQDQAARKIMRFLRRCRHSPLVDHRLYKRSERIEK 1678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Camta	NP_001137624.1	CG-1	422..538	CDD:198144	91/115 (79%)
		TIG	1242..1319	CDD:280079	46/76 (61%)
		ANK	<1405..1497	CDD:238125	44/92 (48%)
		ANK repeat	1405..1447	CDD:293786	23/42 (55%)
		Ank_2	1410..1500	CDD:289560	41/90 (46%)
		ANK repeat	1449..1481	CDD:293786	15/31 (48%)
Camta1	NP_001075026.1	CG-1	67..183	CDD:198144	91/115 (79%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q9Y6Y1, ECO:0000255\|PROSITE-ProRule:PRU00767	112..119		5/6 (83%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	284..375		16/114 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	599..622		6/24 (25%)
		TIG	875..954	CDD:280079	47/79 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	992..1020		2/27 (7%)
		ANK repeat	1066..1109	CDD:293786	23/42 (55%)
		ANK 1. /evidence=ECO:0000255	1066..1095		17/28 (61%)
		ANK	1067..>1165	CDD:238125	47/98 (48%)
		Ank_4	1067..1131	CDD:290365	32/63 (51%)
		ANK repeat	1111..1143	CDD:293786	15/31 (48%)
		ANK 2. /evidence=ECO:0000255	1111..1141		14/29 (48%)
		Ank_4	1114..1165	CDD:290365	24/51 (47%)
		ANK 3. /evidence=ECO:0000255	1145..1174		9/29 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1217..1249		6/31 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1267..1318		5/50 (10%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	213	1.000	Domainoid score	I2740
eggNOG	1	0.900	-	-		E1_KOG0520
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	591	1.000	Inparanoid score	I981
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D161424at33208
OrthoFinder	1	1.000	-	-		FOG0001351
OrthoInspector	1	1.000	-	-		otm42367
orthoMCL	1	0.900	-	-		OOG6_105843
Panther	1	1.100	-	-	LDO	PTHR23335
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3337
SonicParanoid	1	1.000	-	-		X1066
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.990