DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ced-6 and appl1

DIOPT Version :9

Sequence 1:	NP_001246225.1	Gene:	ced-6 / 35971	FlyBaseID:	FBgn0029092	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	XP_021335332.1	Gene:	appl1 / 571540	ZFINID:	ZDB-GENE-081016-1	Length:	708	Species:	Danio rerio

Alignment Length:	295	Identity:	60/295 - (20%)
Similarity:	121/295 - (41%)	Gaps:	67/295 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 QQQQDKDKDAADGGNNTSGGGTGSNSNGDAKSEAKNGKRNWLHTPEQLISGHAVYLVKFFGNLSV 115
            ::...:.|.:|.|......|.:|.:.:.:::....                |.:::|:|.|::.|
Zfish   462 EEHTSQTKSSAQGRRTNPFGESGGSQSEESEDSIL----------------HQLFIVRFLGSMEV 510

  Fly   116 DQPKGIEVVKEAIRKLQFAQQMKKAETGTQEKFKKLEITISIKGVAIQEPRTHKILHQFPLYNIS 180
            ...:..:|:.|.:|::..|:.:......|:.     .:.::.:.:.:.:|:|.....:|||.::.
Zfish   511 KATESSDVIYETMRQILAARAIHNIFRMTES-----HLLVTCECLKLIDPQTQVTRLRFPLSSVV 570

  Fly   181 YCADEKGVKKFFSFIAKTVKTQDGSDPTSNGHANGNGDGSAKVEESHECFVFISNKLASDITLTI 245
            .||..:..|:.|.|:.:|              |.|..||    :....|::|.||.....|..:|
Zfish   571 LCASHQENKRLFGFVLQT--------------AGGRADG----QPVTVCYIFESNNDGEKICDSI 617

  Fly   246 GQAFDLAYRKYMDSTEKTNLSKAQQQINHLQQTVNVYKERLREVSAKLPKAELDALLFNLGIKDI 310
            |.|..:|....||       .||.|:    |:.::..||:.:|...|..:.|          ||:
Zfish   618 GLAKQIALHSEMD-------RKASQK----QRELDKAKEKQQEELHKQKQIE----------KDL 661

  Fly   311 LEAPTTEPQNGIEVASEALSNGKLDDDKLLIDTNS 345
                  |.|:.: :|:.:..|....|.:.|:.:||
Zfish   662 ------EEQSRL-IAASSRPNQPAADGQFLVLSNS 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ced-6	NP_001246225.1	PTB_CED-6	92..261	CDD:269971	36/168 (21%)
ced-6	NP_001246225.1	AceK	233..>304	CDD:295079	18/70 (26%)
appl1	XP_021335332.1	BAR_APPL1	20..234	CDD:153315
		BAR-PH_APPL	252..376	CDD:270067
		PTB_APPL	488..623	CDD:269980	33/173 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3536
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900