DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ced-6 and APPL2

DIOPT Version :9

Sequence 1:	NP_001246225.1	Gene:	ced-6 / 35971	FlyBaseID:	FBgn0029092	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_001238833.1	Gene:	APPL2 / 55198	HGNCID:	18242	Length:	670	Species:	Homo sapiens

Alignment Length:	313	Identity:	55/313 - (17%)
Similarity:	108/313 - (34%)	Gaps:	94/313 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LKTAPTTTMPYQPANSGGTSGGSKAAAKMAQLKFWNKQNSSKQQQQDK------------DKDAA 61
            :|...|......|..|.|....|...::       |.:||..:.:.||            ::..|
Human   394 IKLNQTALQAVTPITSFGKKQESSCPSQ-------NLKNSEMENENDKIVPKATASLPEAEELIA 451

  Fly    62 DGGN-------------NTSGGGTGSNSNGDAKSEAKNGKRNWLHTPEQLISGHAVYLVKFFGNL 113
            .|..             :.:.|...:|..|:.:.|      ::....:.|:  ..:::|:|.|::
Human   452 PGTPIQFDIVLPATEFLDQNRGSRRTNPFGETEDE------SFPEAEDSLL--QQMFIVRFLGSM 508

  Fly   114 SVDQPKGIEVVKEAIRKLQFAQQMKKAETGTQEKFKKLEITISIKGVAIQEPRTHKILHQFPLYN 178
            :|......||:.||:|::..|:.:......|:.     .:.::.:.:.:.:|:|......|.|.:
Human   509 AVKTDSTTEVIYEAMRQVLAARAIHNIFRMTES-----HLMVTSQSLRLIDPQTQVSRANFELTS 568

  Fly   179 ISYCADEKGVKKFFSFIAKTVKTQDGSDPTSNGHANGNGDGSAKVEESHECFVFISNKLASDITL 243
            ::..|..:..|:...|:.:.        |.|.|            |||...::|.||.....|..
Human   569 VTQFAAHQENKRLVGFVIRV--------PESTG------------EESLSTYIFESNSEGEKICY 613

  Fly   244 TIGQAFDLAYRKYMDSTEKTNLSKAQQQINHLQQTVNVYK--ERLREVSAKLP 294
            .|                  ||.|         :.:.|.|  |.|.::...:|
Human   614 AI------------------NLGK---------EIIEVQKDPEALAQLMLSIP 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ced-6	NP_001246225.1	PTB_CED-6	92..261	CDD:269971	30/168 (18%)
ced-6	NP_001246225.1	AceK	233..>304	CDD:295079	12/64 (19%)
APPL2	NP_001238833.1	BAR_APPL2	20..240	CDD:153316
		BAR-PH_APPL	258..382	CDD:270067
		PTB_APPL	488..621	CDD:269980	33/186 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	649..670
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3536
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810