DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ced-6 and ldlrap1

DIOPT Version :9

Sequence 1:	NP_001246225.1	Gene:	ced-6 / 35971	FlyBaseID:	FBgn0029092	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_001017114.1	Gene:	ldlrap1 / 549868	XenbaseID:	XB-GENE-954261	Length:	309	Species:	Xenopus tropicalis

Alignment Length:	365	Identity:	85/365 - (23%)
Similarity:	144/365 - (39%)	Gaps:	95/365 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 SGGGTGSNSNGDAKSEAKNGK-----RNWLHTPEQLISGHAVYLVKFFGNLSVDQPKGIEVVKEA 127
            |.|.....|...||.....||     .||..|.|.|:.|.:.:| |:.|...|:||||.|:...|
Frog     6 SAGRAIIRSPSIAKQSWGGGKHKKLPENWTDTRETLLEGMSFHL-KYLGMTLVEQPKGEELSATA 69

  Fly   128 IRKLQFAQQMKKAETGTQEKFKKLEITISIKGVAIQEPRTHKILHQFPLYNISYCADEKGVKKFF 192
            ::::....:      .:.:|.:|:.:.:|.:|:.:.:..:::::....:|.||||..:|...|.|
Frog    70 VKRIVATAK------ASGKKLQKVILKVSPRGIILYDLASNQLIENVSIYRISYCTADKMHDKVF 128

  Fly   193 SFIAKTVKTQDGSDPTSNGHANGNGDGSAKVEESHECFVFI--SNKLASDITLTIGQAFDLAY-- 253
            ::||:                       ::..|:.||..|:  ..|:|..:|||:.|||.:|:
Frog   129 AYIAQ-----------------------SQQNETLECHAFLCTKRKMAQAVTLTVAQAFKVAFEF 170

  Fly   254 ----RKYMDSTEK---------TNLSKAQQQINHLQQTVNVYKERLREVSAKLPKAELDALLFNL 305
                |:..:..||         ::.|.....|..|:.:          .||.|...|..|..|:.
Frog   171 WQVSRENKEKREKSGSDGEGASSSQSDGSSSITSLKAS----------ASANLLDLEDCAKAFDA 225

  Fly   306 ------GIKDILEAPTTEPQNGIEVASEALSNGKLDDDKLLIDTNSTTASTHSASPSSFLPIVPP 364
                  .|:|:.....:...|.|..|        |||.   :|             .:|..:...
Frog   226 LNASDNHIEDLFRQNESNENNNIVWA--------LDDG---LD-------------EAFSRLAES 266

  Fly   365 RNNLSSQISIGGKSNSQKMDELLLNSDSDS-DFDP-RADE 402
            |.| ...:.||..:|..:.:|.|..|..|. :.:| .|||
Frog   267 RTN-PQVLDIGLTANDLQSEECLSPSSWDKLELNPAEADE 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ced-6	NP_001246225.1	PTB_CED-6	92..261	CDD:269971	42/176 (24%)
ced-6	NP_001246225.1	AceK	233..>304	CDD:295079	20/87 (23%)
ldlrap1	NP_001017114.1	PTB_LDLRAP-mammal-like	43..165	CDD:269981	36/151 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910