DRSC/TRiP Functional Genomics Resources

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Protein Alignment ced-6 and Ldlrap1

DIOPT Version :9

Sequence 1:NP_001246225.1 Gene:ced-6 / 35971 FlyBaseID:FBgn0029092 Length:533 Species:Drosophila melanogaster
Sequence 2:NP_001102741.1 Gene:Ldlrap1 / 500564 RGDID:1563417 Length:307 Species:Rattus norvegicus


Alignment Length:307 Identity:73/307 - (23%)
Similarity:131/307 - (42%) Gaps:61/307 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    80 AKSEAKNGK-----RNWLHTPEQLISGHAVYLVKFFGNLSVDQPKGIEVVKEAIRKLQFAQQMKK 139
            ||.....|:     .||..|.|.|:.| .|:.:|:.|...|::|||.|:...|::::....:   
  Rat    18 AKQSWAGGRHRKLPENWTDTRETLLEG-MVFSLKYLGMTLVERPKGEELSAAAVKRIVATAK--- 78

  Fly   140 AETGTQEKFKKLEITISIKGVAIQEPRTHKILHQFPLYNISYCADEKGVKKFFSFIAKTVKTQDG 204
               .:.:|.:|:.:.:|.:|:.:.:..|.:::....:|.||||..:|...|.|::||:       
  Rat    79 ---ASGKKLQKVTLKVSPRGIILTDSLTSQLIENVSIYRISYCTADKMHDKVFAYIAQ------- 133

  Fly   205 SDPTSNGHANGNGDGSAKVEESHECFVFI--SNKLASDITLTIGQAFDLAYRKY-MDSTEKTNLS 266
                            ::..||.||..|:  ..|:|..:|||:.|||.:|:..: :...||....
  Rat   134 ----------------SQQNESLECHAFLCTKRKVAQAVTLTVAQAFKVAFEFWQVSKEEKEKRE 182

  Fly   267 KAQQQINHLQQT---------VNVYKERLREVSAKLPKAELDALLFNLGIKDILEAPTT------ 316
            ||.|:...:..|         .:|....|.::. :|.||.|..:..|....|....|..      
  Rat   183 KANQEGGDVPGTRRDSTPSLKTSVATGNLLDLE-ELAKAPLSTVSANTKNMDDALRPQVLGNNSV 246

  Fly   317 --EPQNGIEVASEALSNGKLDDDKLLIDTNSTTASTHSA---SPSSF 358
              |..:|::.|...|:..:.:..  ::||..|....|.|   ||:.:
  Rat   247 VWELDDGLDEAFSRLAQSRTNPQ--VLDTGLTAQDIHYAQCLSPTDW 291

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ced-6NP_001246225.1 PTB_CED-6 92..261 CDD:269971 42/171 (25%)
AceK 233..>304 CDD:295079 21/82 (26%)
Ldlrap1NP_001102741.1 PTB_LDLRAP-mammal-like 43..165 CDD:269981 37/151 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 179..205 4/25 (16%)
Clathrin box. /evidence=ECO:0000250|UniProtKB:Q5SW96 211..215 1/3 (33%)
AP-2 complex binding. /evidence=ECO:0000250|UniProtKB:Q5SW96 248..275 6/28 (21%)
[DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. /evidence=ECO:0000250|UniProtKB:Q5SW96 256..265 2/8 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3536
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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