DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ced-6 and Appl2

DIOPT Version :9

Sequence 1:	NP_001246225.1	Gene:	ced-6 / 35971	FlyBaseID:	FBgn0029092	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_001102211.1	Gene:	Appl2 / 362860	RGDID:	1563028	Length:	662	Species:	Rattus norvegicus

Alignment Length:	172	Identity:	35/172 - (20%)
Similarity:	69/172 - (40%)	Gaps:	33/172 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 VYLVKFFGNLSVDQPKGIEVVKEAIRKLQFAQQMKKAETGTQEKFKKLEITISIKGVAIQEPRTH 168
            :::|:|.|:::|......||:.||:|::..|:.:......|:.     .:.::.:.:.:.:|:|.
  Rat   491 MFIVRFLGSMAVKTDSTTEVIYEAMRQVLAARAIHNIFRTTES-----HLMVTSQTLRLIDPQTQ 550

  Fly   169 KILHQFPLYNISYCADEKGVKKFFSFIAKTVKTQDGSDPTSNGHANGNGDGSAKVEESHECFVFI 233
            .....|.|.:::..|..:..|:...|:.:.        |.|.|            |||...::|.
  Rat   551 VSRACFELTSVTQFAAHQENKRLVGFVIRV--------PESTG------------EESLSTYIFE 595

  Fly   234 SNKLASDITLTIGQAFDL--------AYRKYMDSTEKTNLSK 267
            ||.....|...|....::        |..:.|.|...||..|
  Rat   596 SNSEGEKICYAINLGKEIIEVQKDPEALARLMLSVPLTNDGK 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ced-6	NP_001246225.1	PTB_CED-6	92..261	CDD:269971	32/164 (20%)
ced-6	NP_001246225.1	AceK	233..>304	CDD:295079	10/43 (23%)
Appl2	NP_001102211.1	BAR_APPL2	20..234	CDD:153316
		BAR-PH_APPL	252..376	CDD:270067
		PTB_APPL	480..613	CDD:269980	29/146 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	643..662
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3536
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900