Protein Alignment ced-6 and numb

DIOPT Version :9

• Sequence 1: NP_001246225.1
• Gene: ced-6 / 35971
• FlyBaseID: FBgn0029092
• Length: 533
• Species: Drosophila melanogaster
• Sequence 2: NP_001260291.1
• Gene: numb / 34263
• FlyBaseID: FBgn0002973
• Length: 556
• Species: Drosophila melanogaster
• Alignment Length: 599
• Identity: 102/599 - (17%)
• Similarity: 196/599 - (32%)
• Gaps: 181/599 - (30%)

  Fly    19 YQPANSGGTSG--GSKAAAKMAQLKFWNKQNSSKQQQQDKDKDAADGGNNTSGGGTGSNSNGDAK 81
            ::|...|.|.|  |.....|.|..:|..|......:.:...:|:             .....|..
  Fly     9 HEPLERGFTRGKFGDVKNGKSASFRFSKKSPKKMDRLRRSFRDS-------------FRRRKDRV 60

  Fly    82 SEAKNGKRNWLHTPEQLISGHAVYLVKFFGNLSVDQPKGIEVVKEAIRKLQFAQQMKKAETGTQE 146
            .|:.. ...|....|.:.|....:.||:.|.:.|.:.:|::|.:||::.|:  |..::...|.
  Fly    61 PESSK-PHQWQADEEAVRSATCSFSVKYLGCVEVFESRGMQVCEEALKVLR--QSRRRPVRGL-- 120

  Fly   147 KFKKLEITISIKGVAIQEPRTHKILHQFPLYNISYCADEKGVKKFFSFIAKTVKTQDGSDPTSNG 211
                  :.:|..|:.:.:..|..::....:..:|:||.::..::.||:|.:
  Fly   121 ------LHVSGDGLRVVDDETKGLIVDQTIEKVSFCAPDRNHERGFSYICR-------------- 165

  Fly   212 HANGNGDGSAKVEESHECFVFISNKLASD-ITLTIGQAFDLAYRKY--------MDSTEKTNLSK 267
                  ||:.:   ...|..|::.|.:.: ::..:|.||.:...:.        :..|..|..|.
  Fly   166 ------DGTTR---RWMCHGFLACKDSGERLSHAVGCAFAVCLERKQRRDKECGVTMTFDTKNST 221

  Fly   268 AQQQINHLQQTVNVYKERLREVSAKLPKAELDALLFNLGIKDILEAP---TTEPQNGIEVASEAL 329
            ..:..:..|||:.   |||...:....:..:|      |....:..|   |.:|.|...:.....
  Fly   222 FTRTGSFRQQTLT---ERLAMATVGTNERSVD------GPGSAMPGPPAATVKPFNPFAIERPHA 277

  Fly   330 SNGKLDDDKLLIDTNSTTASTHSASPSSF-LPIVPPRNNLSSQISIGGKSNSQKMDELLLNSDSD 393
            :...|:                  ..||| |..:..::....|:|:       ::::|..|:|..
  Fly   278 TPNMLE------------------RQSSFRLSTIGSQSPFKRQMSL-------RINDLPSNADRQ 317

  Fly   394 SDF------DPRADETQEIGGTGRSAISNMFGFEP-------ANSFGQHLFSNNNDHKLQNNNSS 445
            ..|      :|.....:.:......:.:...|.:|       |:|..|.....:....|.....:
  Fly   318 RAFLTAAAGNPMQTPLRSVSPIAEVSPAKSAGADPLSAAAVAADSVSQLCQELSQGLSLLTQTDA 382

  Fly   446 LLIT------SNNNSINSSGFSSELNI------TPPLLAPPPKI--------------------- 477
            ||..      :||.|||.:..::|..:      .||.....|::
  Fly   383 LLAAGEDLNFNNNRSINQNIIAAEKQVQHVHSYAPPTAQVTPRVASTTPTYQTLHSQSPSRSEQS 447

  Fly   478 -----------------------AAPR---------RLNSVTTGNGL---NGNTDLFGSDPFELN 507
                                   |||:         |..::.:|.|.   .|..|    |||:..
  Fly   448 IETSTELPNAEQWLGHVVRSTSPAAPKRPTYLANVGRAQTLASGTGAAVGGGGPD----DPFDAE 508

  Fly   508 NGPNIFKQNQLNLD 521
            ...|:....||:.|
  Fly   509 WVANVAAAKQLSPD 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ced-6	NP_001246225.1	PTB_CED-6	92..261	CDD:269971	30/177 (17%)
		AceK	233..>304	CDD:295079	14/79 (18%)
numb	NP_001260291.1	PTB_Numb	67..201	CDD:241298	31/166 (19%)
		NumbF	269..374	CDD:283874	17/129 (13%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438631
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11232
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940