Protein Alignment ced-6 and LDLRAP1

DIOPT Version :9

• Sequence 1: NP_001246225.1
• Gene: ced-6 / 35971
• FlyBaseID: FBgn0029092
• Length: 533
• Species: Drosophila melanogaster
• Sequence 2: NP_056442.2
• Gene: LDLRAP1 / 26119
• HGNCID: 18640
• Length: 308
• Species: Homo sapiens
• Alignment Length: 313
• Identity: 77/313 - (24%)
• Similarity: 132/313 - (42%)
• Gaps: 76/313 - (24%)

  Fly    68 SGGGTGSNSNGDAKSEAKNGKRNWLHTPEQLISGHAVYLVKFFGNLSVDQPKGIEVVKEAIRKLQ 132
            |.||.|.:         :....||..|.|.|:.| .::.:|:.|...|:||||.|:...||:::.
Human    21 SWGGGGRH---------RKLPENWTDTRETLLEG-MLFSLKYLGMTLVEQPKGEELSAAAIKRIV 75

  Fly   133 FAQQMKKAETGTQEKFKKLEITISIKGVAIQEPRTHKILHQFPLYNISYCADEKGVKKFFSFIAK 197
            ...:      .:.:|.:|:.:.:|.:|:.:.:..|::::....:|.||||..:|...|.|::||:
Human    76 ATAK------ASGKKLQKVTLKVSPRGIILTDNLTNQLIENVSIYRISYCTADKMHDKVFAYIAQ 134

  Fly   198 TVKTQDGSDPTSNGHANGNGDGSAKVEESHECFVFI--SNKLASDITLTIGQAFDLAYRKY-MDS 259
            :...|                       |.||..|:  ..|:|..:|||:.|||.:|:..: :..
Human   135 SQHNQ-----------------------SLECHAFLCTKRKMAQAVTLTVAQAFKVAFEFWQVSK 176

  Fly   260 TEKTNLSKAQQQ--------------INHLQQTVNVYKERLREVSAKLPKAELDALLFNLGIKDI 310
            .||....||.|:              :..|..|.|:..   .|.:||.|.:.:.|...|:.
Human   177 EEKEKRDKASQEGGDVLGARQDCTPSLKSLVATGNLLD---LEETAKAPLSTVSANTTNMD---- 234

  Fly   311 LEAPTTEPQNGIEVASEALSNGKLDD----------DKLLIDTNSTTASTHSA 353
             |.|..:..:|..|..| |.:| ||:          :..::||..|....|.|
Human   235 -EVPRPQALSGSSVVWE-LDDG-LDEAFSRLAQSRTNPQVLDTGLTAQDMHYA 284

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ced-6	NP_001246225.1	PTB_CED-6	92..261	CDD:269971	43/171 (25%)
		AceK	233..>304	CDD:295079	22/87 (25%)
LDLRAP1	NP_056442.2	PTB_LDLRAP-mammal-like	44..166	CDD:269981	38/151 (25%)
		Clathrin box. /evidence=ECO:0000269|PubMed:12221107	212..216		0/6 (0%)
		AP-2 complex binding. /evidence=ECO:0000269|PubMed:12221107	249..276		7/28 (25%)
		[DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. /evidence=ECO:0000269|PubMed:16516836	257..266		0/8 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3536
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810