Protein Alignment ced-6 and APPL1

DIOPT Version :10

• Sequence 1: NP_001246225.1
• Gene: ced-6 / 35971
• FlyBaseID: FBgn0029092
• Length: 533
• Species: Drosophila melanogaster
• Sequence 2: NP_036228.1
• Gene: APPL1 / 26060
• HGNCID: 24035
• Length: 709
• Species: Homo sapiens
• Alignment Length: 248
• Identity: 55/248 - (22%)
• Similarity: 104/248 - (41%)
• Gaps: 45/248 - (18%)

  Fly    51 QQQQDKDKDAADGGNNTSGGGTGSNSNGDAKSEAKNGKRNWLHTPEQLISGHAVYLVKFFGNLSV 115
            :.|..:.|....||..|:..|   .|.|..|||          |.:.::  |.:::|:|.|::.|
Human   463 EDQPGQAKAFGQGGRRTNPFG---ESGGSTKSE----------TEDSIL--HQLFIVRFLGSMEV 512

  Fly   116 DQPKGIEVVKEAIRKLQFAQQMKKAETGTQEKFKKLEITISIKGVAIQEPRTHKILHQFPLYNIS 180
            ......:||.|.:|::..|:.:......|:.     .:.::...:.:.:|:|......|||..:.
Human   513 KSDDHPDVVYETMRQILAARAIHNIFRMTES-----HLLVTCDCLKLIDPQTQVTRLTFPLPCVV 572

  Fly   181 YCADEKGVKKFFSFIAKTVKTQDGSDPTSNGHANGNGDGSAKVEESHECFVFISNKLASDITLTI 245
            ..|..:..|:.|.|:.:          ||:|.:..|        .|..|::|.||.....|..::
Human   573 LYATHQENKRLFGFVLR----------TSSGRSESN--------LSSVCYIFESNNEGEKICDSV 619

  Fly   246 GQAFDLAYRKYMD--STEKTN-----LSKAQQQINHLQQTVNVYKERLREVSA 291
            |.|..:|....:|  ::||..     ..|.|:::|..:|.....:|:.|.::|
Human   620 GLAKQIALHAELDRRASEKQKEIERVKEKQQKELNKQKQIEKDLEEQSRLIAA 672

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ced-6	NP_001246225.1	PTB_CED-6	92..261	CDD:269971	35/170 (21%)
APPL1	NP_036228.1	Required for RAB5A binding	1..428
		BAR_APPL1	20..234	CDD:153315
		BAR-PH_APPL	252..376	CDD:270067
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	397..434
		F&H	403..414
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	467..491		7/26 (27%)
		PTB_APPL	490..625	CDD:269980	36/169 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..709		7/28 (25%)