DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ced-6 and APPL1

DIOPT Version :9

Sequence 1:	NP_001246225.1	Gene:	ced-6 / 35971	FlyBaseID:	FBgn0029092	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_036228.1	Gene:	APPL1 / 26060	HGNCID:	24035	Length:	709	Species:	Homo sapiens

Alignment Length:	248	Identity:	55/248 - (22%)
Similarity:	104/248 - (41%)	Gaps:	45/248 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 QQQQDKDKDAADGGNNTSGGGTGSNSNGDAKSEAKNGKRNWLHTPEQLISGHAVYLVKFFGNLSV 115
            :.|..:.|....||..|:..|   .|.|..|||          |.:.::  |.:::|:|.|::.|
Human   463 EDQPGQAKAFGQGGRRTNPFG---ESGGSTKSE----------TEDSIL--HQLFIVRFLGSMEV 512

  Fly   116 DQPKGIEVVKEAIRKLQFAQQMKKAETGTQEKFKKLEITISIKGVAIQEPRTHKILHQFPLYNIS 180
            ......:||.|.:|::..|:.:......|:.     .:.::...:.:.:|:|......|||..:.
Human   513 KSDDHPDVVYETMRQILAARAIHNIFRMTES-----HLLVTCDCLKLIDPQTQVTRLTFPLPCVV 572

  Fly   181 YCADEKGVKKFFSFIAKTVKTQDGSDPTSNGHANGNGDGSAKVEESHECFVFISNKLASDITLTI 245
            ..|..:..|:.|.|:.:          ||:|.:..|        .|..|::|.||.....|..::
Human   573 LYATHQENKRLFGFVLR----------TSSGRSESN--------LSSVCYIFESNNEGEKICDSV 619

  Fly   246 GQAFDLAYRKYMD--STEKTN-----LSKAQQQINHLQQTVNVYKERLREVSA 291
            |.|..:|....:|  ::||..     ..|.|:::|..:|.....:|:.|.::|
Human   620 GLAKQIALHAELDRRASEKQKEIERVKEKQQKELNKQKQIEKDLEEQSRLIAA 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ced-6	NP_001246225.1	PTB_CED-6	92..261	CDD:269971	35/170 (21%)
ced-6	NP_001246225.1	AceK	233..>304	CDD:295079	16/66 (24%)
APPL1	NP_036228.1	Required for RAB5A binding	1..428
		BAR_APPL1	20..234	CDD:153315
		BAR-PH_APPL	252..376	CDD:270067
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..434
		F&H	403..414
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	467..491		7/26 (27%)
		PTB_APPL	490..625	CDD:269980	36/169 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	645..709		7/28 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3536
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810