Protein Alignment ced-6 and Appl2

DIOPT Version :10

• Sequence 1: NP_001246225.1
• Gene: ced-6 / 35971
• FlyBaseID: FBgn0029092
• Length: 533
• Species: Drosophila melanogaster
• Sequence 2: NP_660255.1
• Gene: Appl2 / 216190
• MGIID: 2384914
• Length: 662
• Species: Mus musculus
• Alignment Length: 267
• Identity: 51/267 - (19%)
• Similarity: 95/267 - (35%)
• Gaps: 74/267 - (27%)

  Fly    42 FWNKQNSSKQQQQDKDKDAADGG---------------------------------NNTSGGGTG 73
            |..||.||...|..|:.|..|..                                 .:.:.||..
Mouse   404 FGKKQESSCSSQNIKNSDIEDDNIVPKATASIPETEELIAPGTPIQFDIVLPATEFLDQNRGGRR 468

  Fly    74 SNSNGDAKSEAKNGKRNWLHTPEQLISGHAVYLVKFFGNLSVDQPKGIEVVKEAIRKLQFAQQMK 138
            :|..|    |.::|  ::....:.|:  ..:::|:|.|:::|......||:.||:|::..|:.:.
Mouse   469 TNPFG----ETEDG--SFPEAEDSLL--QQMFIVRFLGSMAVKTDSTAEVIYEAMRQVLAARAIH 525

  Fly   139 KAETGTQEKFKKLEITISIKGVAIQEPRTHKILHQFPLYNISYCADEKGVKKFFSFIAKTVKTQD 203
            .....|:.     .:.::.:.:.:.:|:|......|.|.:::..|..:..|:...|:.:.
Mouse   526 NIFRMTES-----HLMVTSQTLRLIDPQTQVSRACFELTSVTQFAAHQENKRLVGFVIRV----- 580

  Fly   204 GSDPTSNGHANGNGDGSAKVEESHECFVFISNKLASDITLTIGQAFDL--------AYRKYMDST 260
               |.|.|            |||...::|.||.....|...|....::        |..:.|.|.
Mouse   581 ---PESTG------------EESLSTYIFESNSEGEKICYAINLGKEIIEVQKDPEALARLMLSV 630

  Fly   261 EKTNLSK 267
            ..||..|
Mouse   631 PLTNDGK 637

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ced-6	NP_001246225.1	PTB_CED-6	92..261	CDD:269971	33/176 (19%)
Appl2	NP_660255.1	BAR_APPL2	20..234	CDD:153316
		BAR-PH_APPL	252..376	CDD:270067
		PH domain	278..376
		PTB_APPL	480..613	CDD:269980	30/159 (19%)
		PTB domain	491..607		28/140 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	642..662