DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ced-6 and ced-6

DIOPT Version :9

Sequence 1:	NP_001246225.1	Gene:	ced-6 / 35971	FlyBaseID:	FBgn0029092	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_498203.2	Gene:	ced-6 / 175773	WormBaseID:	WBGene00000420	Length:	492	Species:	Caenorhabditis elegans

Alignment Length:	543	Identity:	149/543 - (27%)
Similarity:	218/543 - (40%)	Gaps:	156/543 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 GGNNTSGGGTGSNSNGDAKSEAKNGK-RNWLHTPEQLISGHAVYLVKFFGNLSVDQPKGIEVVKE 126
            ||||.:|.|:.|.|....:.:.:.|. |.|:|.|:.||:||..|:.:|.|.:...:..|.:|.:|
Worm    18 GGNNINGEGSSSPSTSAPQVKYRGGTGRTWIHPPDYLINGHVEYVARFLGCVETPKANGSDVARE 82

  Fly   127 AIRKLQFAQQMKKAE-TGTQEKFKKLEITISIKGVAIQEPRTHKILHQFPLYNISYCADEKGVKK 190
            ||..::|.:.:|::| |....|.:|:||.|||..|.|.:.:|...::.|||..||:|||:|..|:
Worm    83 AIHAIRFQRDLKRSEQTRETAKLQKVEIRISIDNVIIADIKTKAPMYTFPLGRISFCADDKDDKR 147

  Fly   191 FFSFIAKTVKTQDGSDPTSNGHANGNGDGSAKVEESHECFVFISNKLASDITLTIGQAFDLAYRK 255
            .|||||:.    :|        |:|          ...|:.|.|.|||.|||||||:||||||::
Worm   148 MFSFIARA----EG--------ASG----------KPSCYAFTSEKLAEDITLTIGEAFDLAYKR 190

  Fly   256 YMDSTEKTNLSKAQQ------QINHLQQTVNVYKERLREVSAKLPKAELD-------------AL 301
            ::|. .:|:|...:|      :|..|:....|..|||.|......||:.:             ||
Worm   191 FLDK-NRTSLENQKQIYILKKKIVELETENQVLIERLAEALRANSKADYENTGPPIYPGLGPPAL 254

  Fly   302 LF---------NLGIKDILEAPTTEPQNGIEVAS-----EALSNGKLDDDKLLIDTNSTTASTHS 352
            ..         |:....|...|........|:|.     ...|||.           |.:.|..|
Worm   255 PLSPMPQGPPPNIPPSSIYSMPRANDLPPTEMAPTLPQISTSSNGA-----------SPSVSPAS 308

  Fly   353 ASPSSFLPIVPP---------------RNNLSSQISIGGKSNSQKMDELLLNSDS---------- 392
            .|||...|.:||               ||.:.|.    ..|.:..:|.|.|.|..
Worm   309 TSPSGPAPSIPPPRPPALAPPPPVAPRRNPVVSP----KNSTAGLLDGLELGSAEPAKKAPSNIF 369

  Fly   393 DSDFDPRADETQE-------IGGTGRSAISNMFGFEPANSFGQHLFSNNNDHKLQNNNSSLLITS 450
            |..|||||.|.:.       .|....|.|.|  |.|...|....|.::....:|....||.:
Worm   370 DDSFDPRAGEKKSTAAEYNPFGADFLSGIQN--GKEAPPSASAELLASEAIARLPKPESSSV--- 429

  Fly   451 NNNSINSSGFSSELNITPPLLAPPPKIAA---------PRRLNSVTTGN------------GLNG 494
                                  ||.|.||         .::|.::::|:            |:.|
Worm   430 ----------------------PPKKTAAEYDAMINEVEKKLAAMSSGSFEFGQLQTGDLGGIEG 472

  Fly   495 NTDLFGSDPFELNNGPNIFKQNQ 517
            .:| :|:....||  |.:....|
Worm   473 ESD-YGTPSDRLN--PKMMNLKQ 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ced-6	NP_001246225.1	PTB_CED-6	92..261	CDD:269971	66/169 (39%)
ced-6	NP_001246225.1	AceK	233..>304	CDD:295079	32/98 (33%)
ced-6	NP_498203.2	PTB_CED-6	48..196	CDD:269971	52/148 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166904
Domainoid	1	1.000	101	1.000	Domainoid score	I4378
eggNOG	1	0.900	-	-		E1_KOG3536
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005528
OrthoInspector	1	1.000	-	-		oto20347
orthoMCL	1	0.900	-	-		OOG6_108573
Panther	1	1.100	-	-	LDO	PTHR11232
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2449
SonicParanoid	1	1.000	-	-		X3949
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.730