DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ced-6 and appl2

DIOPT Version :9

Sequence 1:	NP_001246225.1	Gene:	ced-6 / 35971	FlyBaseID:	FBgn0029092	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_001121547.1	Gene:	appl2 / 100000135	ZFINID:	ZDB-GENE-081016-2	Length:	662	Species:	Danio rerio

Alignment Length:	229	Identity:	50/229 - (21%)
Similarity:	82/229 - (35%)	Gaps:	49/229 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 GSNSNGDAKSEAKNGKRNWLHTPEQLISGHAVYLVKFFGNLSVDQPKGIEVVKEAIRKLQFAQQM 137
            |.....|.:|:          |.:.|:  ..|:.|:|.|:::|......||:.||:|::..|:.:
Zfish   473 GETEEDDDESD----------THDSLL--QQVFAVRFLGSMAVRSGHTQEVIYEAMRQVLAARAI 525

  Fly   138 KKAETGTQEKFKKLE--ITISIKGVAIQEPRTHKILHQFPLYNISYCADEKGVKKFFSFIAKTVK 200
            ...       ||..|  :.||...:.:.:|:|......|.|..:|..|..:..::...|:.::..
Zfish   526 HNI-------FKTTESHLMISSSCIRLIDPQTQVTKISFQLQEVSEFAAHQENERLMGFVVRSSA 583

  Fly   201 TQDGSDPTSNGHANGNGDGSAKVEESHECFVFISNKLASDITLTIGQAFDL--------AYRKYM 257
            ..|                    |.|...|||.||.....|..||..|.::        |..:.|
Zfish   584 EDD--------------------EPSFSVFVFESNTEGEKICYTINLAKEIADARKDPEALAQLM 628

  Fly   258 DSTEKTNLSKAQQQINHLQQTVNVYKERLREVSA 291
            .|...||..|.....|....|.....:..:|..|
Zfish   629 KSMPLTNDGKFLLLDNETGDTAETAGQEQQESEA 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ced-6	NP_001246225.1	PTB_CED-6	92..261	CDD:269971	40/178 (22%)
ced-6	NP_001246225.1	AceK	233..>304	CDD:295079	16/67 (24%)
appl2	NP_001121547.1	BAR	21..235	CDD:299863
		BAR-PH_APPL	253..375	CDD:270067
		PH	277..377	CDD:278594
		PTB_APPL	488..614	CDD:269980	36/154 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3536
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900