DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdk and Pdk4

DIOPT Version :9

Sequence 1:	NP_001097240.1	Gene:	Pdk / 35970	FlyBaseID:	FBgn0017558	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_446003.2	Gene:	Pdk4 / 89813	RGDID:	69061	Length:	412	Species:	Rattus norvegicus

Alignment Length:	416	Identity:	213/416 - (51%)
Similarity:	291/416 - (69%)	Gaps:	20/416 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FPVRFSAASSSMASLAKMLDFYSGFNPSPLSIKQFMDFG-QNACEKKSYIFLRKELPVRLANIMK 67
            |.:|.:::..:...:.:.::.:|.::|||||:||.:||| :||||:.|:.|||:|||||||||:|
  Rat     6 FVMRSASSLGNAGLVPREVELFSRYSPSPLSMKQLLDFGSENACERTSFSFLRQELPVRLANILK 70

  Fly    68 EIALLPDNLLHTRSVSEVSSWYVKSFEDVL-VYEKAEPTHDNLQKFVADLDLIRNRHNDVVQTMA 131
            ||.:||:.|::|.||..|.|||::|..|:: .:||:......|..||..|..:||||::||.|||
  Rat    71 EIDILPERLVNTPSVQLVKSWYIQSLMDLVEFHEKSPEDQKALSDFVDTLVKVRNRHHNVVPTMA 135

  Fly   132 QGVIEMKENEGGQVDAPTESSIQYFLDRLYMSRISIRMLINQHTLLFG----GNPHAGGRHIGCL 192
            ||::|.|:|  ..||..|..::||||||.||:|||.|||:|||.|:|.    |||    .|||.:
  Rat   136 QGILEYKDN--CTVDPVTNQNLQYFLDRFYMNRISTRMLMNQHILIFSDSKTGNP----SHIGSI 194

  Fly   193 DPACDLSDVVRDAYENARFLCDQYYLTSPALEIQQHSSE-PGDNLPIRTVYVPSHLYYMLFELFK 256
            ||.||:..||.||:|.|:.||||||||||.|::.|.:.: ||.  ||..|||||||::|||||||
  Rat   195 DPNCDVVAVVEDAFECAKMLCDQYYLTSPELKLTQVNGKFPGQ--PIHIVYVPSHLHHMLFELFK 257

  Fly   257 NSMRAVVEHHGHDNNDTLPPLKVAICKGKEDICVKISDQGGGIPRSQTDQLFKYMYSTAPQPSKS 321
            |:|||.|||  .:|..:|.|::..:..||||:.:||||:|||:|...||:||.|.|||||.|...
  Rat   258 NAMRATVEH--QENRPSLTPVEATVVLGKEDLTIKISDRGGGVPLRITDRLFSYTYSTAPTPVMD 320

  Fly   322 DLHTVPLAGYGYGLPISRLYARYFHGDIVLLSCEGFGTDAIIYLKALSDEANELLPIFNKTSSKF 386
            :....||||:|||||||||||:||.||:.|.|..|:||||||||||||.|:.|.||:|||::.|.
  Rat   321 NSRNAPLAGFGYGLPISRLYAKYFQGDLNLYSMSGYGTDAIIYLKALSSESIEKLPVFNKSAFKH 385

  Fly   387 YRATVPTGDW---SNQSSDMNARQLS 409
            |:.:....||   |.:..:::..:|:
  Rat   386 YQMSSEADDWCIPSKEPKNLSKEKLA 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdk	NP_001097240.1	BCDHK_Adom3	32..193	CDD:402181	88/166 (53%)
Pdk	NP_001097240.1	HATPase_PDK-like	197..366	CDD:340406	99/169 (59%)
Pdk4	NP_446003.2	BCDHK_Adom3	34..195	CDD:402181	88/166 (53%)
Pdk4	NP_446003.2	HATPase_PDK-like	199..365	CDD:340406	99/169 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340942
Domainoid	1	1.000	183	1.000	Domainoid score	I3338
eggNOG	1	0.900	-	-		E1_COG0642
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	442	1.000	Inparanoid score	I1600
OMA	1	1.010	-	-		QHG56575
OrthoDB	1	1.010	-	-		D1242599at2759
OrthoFinder	1	1.000	-	-		FOG0000382
OrthoInspector	1	1.000	-	-		otm44546
orthoMCL	1	0.900	-	-		OOG6_100725
Panther	1	1.100	-	-	O	PTHR11947
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X391
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770