DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdk and pdk2a

DIOPT Version :9

Sequence 1:	NP_001097240.1	Gene:	Pdk / 35970	FlyBaseID:	FBgn0017558	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	XP_001332594.3	Gene:	pdk2a / 794083	ZFINID:	ZDB-GENE-120910-1	Length:	409	Species:	Danio rerio

Alignment Length:	412	Identity:	228/412 - (55%)
Similarity:	295/412 - (71%)	Gaps:	15/412 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VRFSAASSSMASLAKMLDFYSGFNPSPLSIKQFMDFGQ-NACEKKSYIFLRKELPVRLANIMKEI 69
            |||...::::|::...::.:|.|:|||||:|||:|||. |||||.|::|||:||||||:||||||
Zfish     4 VRFIMKNAALANVPHHIEHFSKFSPSPLSMKQFLDFGSTNACEKTSFVFLRQELPVRLSNIMKEI 68

  Fly    70 ALLPDNLLHTRSVSEVSSWYVKSFEDVLVY-EKAEPTHDNLQKFVADLDLIRNRHNDVVQTMAQG 133
            .|||..||.|.||..|.|||::|..::|.: ||:...|..|::|||.|..|||||||||.|||||
Zfish    69 NLLPKRLLTTPSVQMVHSWYIQSLMEILEFLEKSPDDHSILEEFVAALVNIRNRHNDVVPTMAQG 133

  Fly   134 VIEMKENEGGQVDAPTESSIQYFLDRLYMSRISIRMLINQHTLLFGG--NP-HAGGRHIGCLDPA 195
            |||.||..|  .|..|..:|||||||.|:||||||||||||||:|.|  || |.  ..||.:||.
Zfish   134 VIEYKEVFG--QDPVTNQNIQYFLDRFYLSRISIRMLINQHTLVFDGATNPVHP--NTIGSIDPH 194

  Fly   196 CDLSDVVRDAYENARFLCDQYYLTSPALEIQQHSSEPGDNLPIRTVYVPSHLYYMLFELFKNSMR 260
            |.::|||:||||:||.|||||||.||.|::|:.::. ..|.||..||||||||::|||||||:||
Zfish   195 CQVADVVKDAYESARMLCDQYYLNSPDLDLQELNTN-NRNQPISIVYVPSHLYHILFELFKNAMR 258

  Fly   261 AVVEHHGHDNNDTLPPLKVAICKGKEDICVKISDQGGGIPRSQTDQLFKYMYSTAPQPSKSDLHT 325
            |.:|.|...:|  ||.::|.:..|.||:.:|:||:|||:|..:.:.||.|||||||.|...:...
Zfish   259 ATIESHKEGSN--LPAIQVMVAVGGEDLTIKMSDRGGGVPFRKMENLFSYMYSTAPTPQMDEKQR 321

  Fly   326 VPLAGYGYGLPISRLYARYFHGDIVLLSCEGFGTDAIIYLKALSDEANELLPIFNKTSSKFYRAT 390
            .||||:|||||||||||:||.||:.|.|.||.||||:|:|||||.::.|.||:||||:.:.|..|
Zfish   322 APLAGFGYGLPISRLYAKYFQGDLQLYSMEGHGTDAVIHLKALSTDSVERLPVFNKTARRNYEVT 386

  Fly   391 VPTGDW---SNQSSDMNARQLS 409
            ....||   |.:..|:...:|:
Zfish   387 QGADDWCVPSREPLDLAVFKLA 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdk	NP_001097240.1	BCDHK_Adom3	32..193	CDD:402181	103/165 (62%)
Pdk	NP_001097240.1	HATPase_PDK-like	197..366	CDD:340406	95/168 (57%)
pdk2a	XP_001332594.3	BCDHK_Adom3	30..192	CDD:313630	103/165 (62%)
pdk2a	XP_001332594.3	HATPase_c	242..362	CDD:214643	69/121 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580820
Domainoid	1	1.000	182	1.000	Domainoid score	I3390
eggNOG	1	0.900	-	-		E1_COG0642
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	432	1.000	Inparanoid score	I1678
OMA	1	1.010	-	-		QHG56575
OrthoDB	1	1.010	-	-		D1242599at2759
OrthoFinder	1	1.000	-	-		FOG0000382
OrthoInspector	1	1.000	-	-		otm25437
orthoMCL	1	0.900	-	-		OOG6_100725
Panther	1	1.100	-	-	LDO	PTHR11947
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R894
SonicParanoid	1	1.000	-	-		X391
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800