DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdk and pdk4

DIOPT Version :9

Sequence 1:	NP_001097240.1	Gene:	Pdk / 35970	FlyBaseID:	FBgn0017558	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_001122176.1	Gene:	pdk4 / 561007	ZFINID:	ZDB-GENE-060503-754	Length:	409	Species:	Danio rerio

Alignment Length:	396	Identity:	223/396 - (56%)
Similarity:	287/396 - (72%)	Gaps:	12/396 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 SSSMASLAKMLDFYSGFNPSPLSIKQFMDFGQ-NACEKKSYIFLRKELPVRLANIMKEIALLPDN 75
            :||..::.|.:|.:|.|:|||||:|||:|||. |||||.|::|||:|||||||||||||..|||.
Zfish    10 NSSKLNIPKQVDRFSKFSPSPLSMKQFIDFGSANACEKTSFMFLRQELPVRLANIMKEIDFLPDK 74

  Fly    76 LLHTRSVSEVSSWYVKSFEDVLVYEKAEPTHDN-LQKFVADLDLIRNRHNDVVQTMAQGVIEMKE 139
            ||.|.|:..:.|||.:|..:::.:.:.:|.... |.||...|..:|||||:||.||||||:|.||
Zfish    75 LLGTPSLKLLQSWYAQSLMELVDFLEKDPDDKKILTKFTETLINVRNRHNNVVPTMAQGVLEYKE 139

  Fly   140 NEGGQVDAPTESSIQYFLDRLYMSRISIRMLINQHTLLFGG--NPHAGGRHIGCLDPACDLSDVV 202
            ..|  ||..|..::||||||.||||||.|||:|||||:|.|  || |..:|||.:||.||:.:||
Zfish   140 AFG--VDPVTNQNVQYFLDRFYMSRISTRMLMNQHTLIFDGSTNP-AHPKHIGSIDPNCDVVEVV 201

  Fly   203 RDAYENARFLCDQYYLTSPALEIQQ-HSSEPGDNLPIRTVYVPSHLYYMLFELFKNSMRAVVEHH 266
            |||||:::.||||||||||.:||:| :...|.|  ||..||||||||:||||||||:|||.||
Zfish   202 RDAYESSKMLCDQYYLTSPEVEIKQVNIKGPSD--PIHIVYVPSHLYHMLFELFKNAMRATVE-- 262

  Fly   267 GHDNNDTLPPLKVAICKGKEDICVKISDQGGGIPRSQTDQLFKYMYSTAPQPSKSDLHTVPLAGY 331
            .|:.:..|||:||.:..|.||:.:|:||:|.|:|..:.::||.|||||||.|...|....||||:
Zfish   263 THETSLHLPPIKVRVSLGTEDLTIKMSDRGSGVPLRKIERLFSYMYSTAPSPVAEDTRNAPLAGF 327

  Fly   332 GYGLPISRLYARYFHGDIVLLSCEGFGTDAIIYLKALSDEANELLPIFNKTSSKFYRATVPTGDW 396
            |||||||||||:||.||:.|.|.||:||.|:|||||||.|:.|.||:|||::.:.|:.:....||
Zfish   328 GYGLPISRLYAKYFQGDLQLYSMEGYGTSAVIYLKALSTESIERLPVFNKSALRHYQTSTEADDW 392

  Fly   397 SNQSSD 402
            ...||:
Zfish   393 CIPSSE 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdk	NP_001097240.1	BCDHK_Adom3	32..193	CDD:402181	95/164 (58%)
Pdk	NP_001097240.1	HATPase_PDK-like	197..366	CDD:340406	100/169 (59%)
pdk4	NP_001122176.1	BCDHK_Adom3	30..192	CDD:287417	95/164 (58%)
		BaeS	<196..370	CDD:223715	106/177 (60%)
		HATPase_c	242..362	CDD:214643	72/121 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580816
Domainoid	1	1.000	182	1.000	Domainoid score	I3390
eggNOG	1	0.900	-	-		E1_COG0642
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	432	1.000	Inparanoid score	I1678
OMA	1	1.010	-	-		QHG56575
OrthoDB	1	1.010	-	-		D1242599at2759
OrthoFinder	1	1.000	-	-		FOG0000382
OrthoInspector	1	1.000	-	-		otm25437
orthoMCL	1	0.900	-	-		OOG6_100725
Panther	1	1.100	-	-	O	PTHR11947
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X391
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.770