Protein Alignment Pdk and PDK4

DIOPT Version :9

• Sequence 1: NP_001097240.1
• Gene: Pdk / 35970
• FlyBaseID: FBgn0017558
• Length: 422
• Species: Drosophila melanogaster
• Sequence 2: NP_002603.1
• Gene: PDK4 / 5166
• HGNCID: 8812
• Length: 411
• Species: Homo sapiens
• Alignment Length: 399
• Identity: 209/399 - (52%)
• Similarity: 280/399 - (70%)
• Gaps: 15/399 - (3%)

  Fly     4 FPVRFSAASSSMASLAKMLDFYSGFNPSPLSIKQFMDFG-QNACEKKSYIFLRKELPVRLANIMK 67
            |.:|.:.:.:....:.:.::.:|.::|||||:||.:||| :||||:.|:.|||:|||||||||:|
Human     6 FVLRSAGSLNGAGLVPREVEHFSRYSPSPLSMKQLLDFGSENACERTSFAFLRQELPVRLANILK 70

  Fly    68 EIALLPDNLLHTRSVSEVSSWYVKSFEDVL-VYEKAEPTHDNLQKFVADLDLIRNRHNDVVQTMA 131
            ||.:||..|::|.||..|.|||::|..|:: .:||:......|..||..|..:||||::||.|||
Human    71 EIDILPTQLVNTSSVQLVKSWYIQSLMDLVEFHEKSPDDQKALSDFVDTLIKVRNRHHNVVPTMA 135

  Fly   132 QGVIEMKENEGGQVDAPTESSIQYFLDRLYMSRISIRMLINQHTLLFG----GNPHAGGRHIGCL 192
            ||:||.|  :...||..|..::||||||.||:|||.|||:|||.|:|.    |||    .|||.:
Human   136 QGIIEYK--DACTVDPVTNQNLQYFLDRFYMNRISTRMLMNQHILIFSDSQTGNP----SHIGSI 194

  Fly   193 DPACDLSDVVRDAYENARFLCDQYYLTSPALEIQQHSSEPGDNLPIRTVYVPSHLYYMLFELFKN 257
            ||.||:..||:||:|.:|.|||||||:||.|::.|.:.:..|. ||..|||||||::||||||||
Human   195 DPNCDVVAVVQDAFECSRMLCDQYYLSSPELKLTQVNGKFPDQ-PIHIVYVPSHLHHMLFELFKN 258

  Fly   258 SMRAVVEHHGHDNNDTLPPLKVAICKGKEDICVKISDQGGGIPRSQTDQLFKYMYSTAPQPSKSD 322
            :|||.|||  .:|..:|.|::|.:..||||:.:||||:|||:|....|:||.|.|||||.|...:
Human   259 AMRATVEH--QENQPSLTPIEVIVVLGKEDLTIKISDRGGGVPLRIIDRLFSYTYSTAPTPVMDN 321

  Fly   323 LHTVPLAGYGYGLPISRLYARYFHGDIVLLSCEGFGTDAIIYLKALSDEANELLPIFNKTSSKFY 387
            ....||||:|||||||||||:||.||:.|.|..|:||||||||||||.|:.|.||:|||::.|.|
Human   322 SRNAPLAGFGYGLPISRLYAKYFQGDLNLYSLSGYGTDAIIYLKALSSESIEKLPVFNKSAFKHY 386

  Fly   388 RATVPTGDW 396
            :.:....||
Human   387 QMSSEADDW 395

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdk	NP_001097240.1	BCDHK_Adom3	32..193	CDD:402181	88/166 (53%)
		HATPase_PDK-like	197..366	CDD:340406	97/168 (58%)
PDK4	NP_002603.1	BCDHK_Adom3	34..195	CDD:313630	88/166 (53%)
		HATPase_c	245..365	CDD:214643	73/121 (60%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147295
Domainoid	1	1.000	181	1.000	Domainoid score	I3480
eggNOG	1	0.900	-	-		E1_COG0642
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	440	1.000	Inparanoid score	I1670
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56575
OrthoDB	1	1.010	-	-		D1242599at2759
OrthoFinder	1	1.000	-	-		FOG0000382
OrthoInspector	1	1.000	-	-		otm40408
orthoMCL	1	0.900	-	-		OOG6_100725
Panther	1	1.100	-	-	O	PTHR11947
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R894
SonicParanoid	1	1.000	-	-		X391
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800