Protein Alignment Pdk and PDK3

DIOPT Version :10

• Sequence 1: NP_001097240.1
• Gene: Pdk / 35970
• FlyBaseID: FBgn0017558
• Length: 422
• Species: Drosophila melanogaster
• Sequence 2: NP_001135858.1
• Gene: PDK3 / 5165
• HGNCID: 8811
• Length: 415
• Species: Homo sapiens
• Alignment Length: 413
• Identity: 236/413 - (57%)
• Similarity: 292/413 - (70%)
• Gaps: 29/413 - (7%)

  Fly     1 MRLF------PVRFSAASSSMASLAKMLDFYSGFNPSPLSIKQFMDFGQ-NACEKKSYIFLRKEL 58
            ||||      ||            .|.::.||.|:|||||||||:|||: |||||.||:||||||
Human     1 MRLFRWLLKQPV------------PKQIERYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKEL 53

  Fly    59 PVRLANIMKEIALLPDNLLHTRSVSEVSSWYVKSFEDVLVYEKAEPTHDN-LQKFVADLDLIRNR 122
            ||||||.|:|:.|||||||:..||..|.|||::||.::|.||...|.... |..|:..|..:|||
Human    54 PVRLANTMREVNLLPDNLLNRPSVGLVQSWYMQSFLELLEYENKSPEDPQVLDNFLQVLIKVRNR 118

  Fly   123 HNDVVQTMAQGVIEMKENEGGQVDAPTESSIQYFLDRLYMSRISIRMLINQHTLLFGG--NP-HA 184
            |||||.||||||||.||..|  .|....::|||||||.|.:|||.|||||||||||||  || |.
Human   119 HNDVVPTMAQGVIEYKEKFG--FDPFISTNIQYFLDRFYTNRISFRMLINQHTLLFGGDTNPVHP 181

  Fly   185 GGRHIGCLDPACDLSDVVRDAYENARFLCDQYYLTSPALEIQQHSSEPGDNLPIRTVYVPSHLYY 249
              :|||.:||.|:::|||:||||.|:.||:||||.:|.||:::.:::..|. ||:.|||||||::
Human   182 --KHIGSIDPTCNVADVVKDAYETAKMLCEQYYLVAPELEVEEFNAKAPDK-PIQVVYVPSHLFH 243

  Fly   250 MLFELFKNSMRAVVEHHGHDNNDTLPPLKVAICKGKEDICVKISDQGGGIPRSQTDQLFKYMYST 314
            ||||||||||||.||.: .|..:..|.:|..:..||||:.:||||.|||:|..:.|:||.|||||
Human   244 MLFELFKNSMRATVELY-EDRKEGYPAVKTLVTLGKEDLSIKISDLGGGVPLRKIDRLFNYMYST 307

  Fly   315 APQPSKSDLHTVPLAGYGYGLPISRLYARYFHGDIVLLSCEGFGTDAIIYLKALSDEANELLPIF 379
            ||:||.......||||:||||||||||||||.||:.|.|.||.||||:|||||||.|:.|.||:|
Human   308 APRPSLEPTRAAPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLKALSSESFERLPVF 372

  Fly   380 NKTSSKFYRATVPTGDWSNQSSD 402
            ||::.:.|:.|....||||.||:
Human   373 NKSAWRHYKTTPEADDWSNPSSE 395

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdk	NP_001097240.1	BCDHK_Adom3	32..193	CDD:463093	103/165 (62%)
		HATPase_PDK-like	197..366	CDD:340406	98/168 (58%)
PDK3	NP_001135858.1	BCDHK_Adom3	26..188	CDD:463093	103/165 (62%)
		HATPase_PDK-like	192..359	CDD:340406	98/168 (58%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	383..406		7/13 (54%)