DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pdk and PDK1

DIOPT Version :9

Sequence 1:	NP_001097240.1	Gene:	Pdk / 35970	FlyBaseID:	FBgn0017558	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_001265478.1	Gene:	PDK1 / 5163	HGNCID:	8809	Length:	456	Species:	Homo sapiens

Alignment Length:	433	Identity:	229/433 - (52%)
Similarity:	296/433 - (68%)	Gaps:	39/433 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FPVRFSAAS-SSMAS---LAKMLDFYSGFNPSPLSIKQFMDFGQ-NACEKKSYIFLRKELPVRLA 63
            |...||:.| ||.||   :...:|||:.|:|||||:|||:|||. |||||.|::|||:|||||||
Human    24 FSRSFSSDSGSSPASERGVPGQVDFYARFSPSPLSMKQFLDFGSVNACEKTSFMFLRQELPVRLA 88

  Fly    64 NIMKEIALLPDNLLHTRSVSEVSSWYVKSFEDVL------------VYEKAEPTHDNLQK----- 111
            ||||||:|||||||.|.||..|.|||::|.:::|            :||:...|...:..
Human    89 NIMKEISLLPDNLLRTPSVQLVQSWYIQSLQELLDFKDKSAEDAKAIYERPRRTWLQVSSLCCMA 153

  Fly   112 ----FVADLDLIRNRHNDVVQTMAQGVIEMKENEGGQVDAPTESSIQYFLDRLYMSRISIRMLIN 172
                |...:..||||||||:.||||||||.||:.|  ||..|..::||||||.||||||||||:|
Human   154 CKMIFTDTVIRIRNRHNDVIPTMAQGVIEYKESFG--VDPVTSQNVQYFLDRFYMSRISIRMLLN 216

  Fly   173 QHTLLFGGNPHAG---GRHIGCLDPACDLSDVVRDAYENARFLCDQYYLTSPALEIQQ-HSSEPG 233
            ||:|||||.....   .:|||.::|.|::.:|::|.|||||.|||.||:.||.||::: ::..||
Human   217 QHSLLFGGKGKGSPSHRKHIGSINPNCNVLEVIKDGYENARRLCDLYYINSPELELEELNAKSPG 281

  Fly   234 DNLPIRTVYVPSHLYYMLFELFKNSMRAVVEHHGHDNNDTLPPLKVAICKGKEDICVKISDQGGG 298
            .  ||:.||||||||:|:||||||:|||.:|||.  |....||::|.:..|.||:.||:||:|||
Human   282 Q--PIQVVYVPSHLYHMVFELFKNAMRATMEHHA--NRGVYPPIQVHVTLGNEDLTVKMSDRGGG 342

  Fly   299 IPRSQTDQLFKYMYSTAPQPSKSDLHTVPLAGYGYGLPISRLYARYFHGDIVLLSCEGFGTDAII 363
            :|..:.|:||.|||||||:|.......|||||:|||||||||||:||.||:.|.|.||:||||:|
Human   343 VPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVI 407

  Fly   364 YLKALSDEANELLPIFNKTSSKFYRATVPTGDW---SNQSSDM 403
            |:||||.::.|.||::||.:.|.|.......||   |.:..||
Human   408 YIKALSTDSIERLPVYNKAAWKHYNTNHEADDWCVPSREPKDM 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdk	NP_001097240.1	BCDHK_Adom3	32..193	CDD:402181	100/185 (54%)
Pdk	NP_001097240.1	HATPase_PDK-like	197..366	CDD:340406	97/169 (57%)
PDK1	NP_001265478.1	BCDHK_Adom3	56..240	CDD:287417	100/185 (54%)
		BaeS	<244..418	CDD:223715	101/177 (57%)
		HATPase_c	290..410	CDD:214643	74/121 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147294
Domainoid	1	1.000	181	1.000	Domainoid score	I3480
eggNOG	1	0.900	-	-		E1_COG0642
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	440	1.000	Inparanoid score	I1670
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56575
OrthoDB	1	1.010	-	-		D1242599at2759
OrthoFinder	1	1.000	-	-		FOG0000382
OrthoInspector	1	1.000	-	-		otm40408
orthoMCL	1	0.900	-	-		OOG6_100725
Panther	1	1.100	-	-	O	PTHR11947
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R894
SonicParanoid	1	1.000	-	-		X391
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800