DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pdk and Pdk1

DIOPT Version :9

Sequence 1:	NP_001097240.1	Gene:	Pdk / 35970	FlyBaseID:	FBgn0017558	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	XP_011237746.1	Gene:	Pdk1 / 228026	MGIID:	1926119	Length:	471	Species:	Mus musculus

Alignment Length:	442	Identity:	225/442 - (50%)
Similarity:	294/442 - (66%)	Gaps:	53/442 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SAASSSMAS---LAKMLDFYSGFNPSPLSIKQFMDFGQ-NACEKKSYIFLRKELPVRLANIMKEI 69
            ||:.|..||   :...:|||:.|:|||||:|||:|||. |||||.|::|||:|||||||||||||
Mouse    30 SASGSGPASELGVPGQVDFYARFSPSPLSMKQFLDFGSVNACEKTSFMFLRQELPVRLANIMKEI 94

  Fly    70 ALLPDNLLHTRSVSEVSSW-------------------------------------YVKSFEDVL 97
            :|||||||.|.||..|.||                                     |::|.:::|
Mouse    95 SLLPDNLLRTPSVQLVQSWPGAQHTDQVDMELAAILLPLPLWYYRDVLPCPVTVSRYIQSLQELL 159

  Fly    98 VY-EKAEPTHDNLQKFVADLDLIRNRHNDVVQTMAQGVIEMKENEGGQVDAPTESSIQYFLDRLY 161
            .: :|:......:.:|...:..||||||||:.||||||.|.||:.|  ||..|..::||||||.|
Mouse   160 DFKDKSAEDAKTIYEFTDTVIRIRNRHNDVIPTMAQGVTEYKESFG--VDPVTSQNVQYFLDRFY 222

  Fly   162 MSRISIRMLINQHTLLFGGNPHAGGR-HIGCLDPACDLSDVVRDAYENARFLCDQYYLTSPALEI 225
            |||||||||:|||:|||||......| |||.::|.||:.:|::|.|||||.|||.||:.||.||:
Mouse   223 MSRISIRMLLNQHSLLFGGKGSPSHRKHIGSINPNCDVVEVIKDGYENARRLCDLYYVNSPELEL 287

  Fly   226 QQ-HSSEPGDNLPIRTVYVPSHLYYMLFELFKNSMRAVVEHHGHDNNDTLPPLKVAICKGKEDIC 289
            :: ::..||..  |:.||||||||:|:||||||:|||.:|||.  :....||::|.:..|:||:.
Mouse   288 EELNAKSPGQT--IQVVYVPSHLYHMVFELFKNAMRATMEHHA--DKGVYPPIQVHVTLGEEDLT 348

  Fly   290 VKISDQGGGIPRSQTDQLFKYMYSTAPQPSKSDLHTVPLAGYGYGLPISRLYARYFHGDIVLLSC 354
            ||:||:|||:|..:.|:||.|||||||:|.......|||||:|||||||||||:||.||:.|.|.
Mouse   349 VKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDLKLYSL 413

  Fly   355 EGFGTDAIIYLKALSDEANELLPIFNKTSSKFYRATVPTGDW---SNQSSDM 403
            ||:||||:||:||||.|:.|.||::||.:.|.|:|.....||   |.:..||
Mouse   414 EGYGTDAVIYIKALSTESVERLPVYNKAAWKHYKANHEADDWCVPSREPKDM 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdk	NP_001097240.1	BCDHK_Adom3	32..193	CDD:402181	98/200 (49%)
Pdk	NP_001097240.1	HATPase_PDK-like	197..366	CDD:340406	96/169 (57%)
Pdk1	XP_011237746.1	BCDHK_Adom3	56..255	CDD:371050	98/200 (49%)
Pdk1	XP_011237746.1	HATPase_PDK-like	259..425	CDD:340406	96/169 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837226
Domainoid	1	1.000	183	1.000	Domainoid score	I3418
eggNOG	1	0.900	-	-		E1_COG0642
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	444	1.000	Inparanoid score	I1626
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56575
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000382
OrthoInspector	1	1.000	-	-		otm42480
orthoMCL	1	0.900	-	-		OOG6_100725
Panther	1	1.100	-	-	O	PTHR11947
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R894
SonicParanoid	1	1.000	-	-		X391
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790