DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdk and pdhk-2

DIOPT Version :9

Sequence 1:	NP_001097240.1	Gene:	Pdk / 35970	FlyBaseID:	FBgn0017558	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_498928.1	Gene:	pdhk-2 / 176226	WormBaseID:	WBGene00022719	Length:	401	Species:	Caenorhabditis elegans

Alignment Length:	396	Identity:	210/396 - (53%)
Similarity:	284/396 - (71%)	Gaps:	10/396 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VRFS--AASSSMASLAKMLDFYSGFNPSPLSIKQFMDFGQNACEKKSYIFLRKELPVRLANIMKE 68
            :|||  .....:.||||.||:||.|.||.|:|:|::|||:......||.||:.||.|||||||:|
Worm     1 MRFSRKLLGPFVGSLAKKLDYYSQFQPSSLTIQQYLDFGRIGTSANSYTFLKNELLVRLANIMQE 65

  Fly    69 IALLPDNLLHTRSVSEVSSWYVKSFEDVLVYEKAEPTHDNLQKFVADLDLIRNRHNDVVQTMAQG 133
            ..|||..||...|...||:||.:||||:|::|.::.:.:.:.:|...|.::..||..||:|||:|
Worm    66 FTLLPPKLLQMPSSKMVSNWYAESFEDLLLFEASDSSPEQVARFNDQLTVVLKRHAHVVETMAEG 130

  Fly   134 VIEMKENEGGQVDAPTESSIQYFLDRLYMSRISIRMLINQHTLLFGGNPHAGGRHIGCLDPACDL 198
            :||::|::|  ||..:|..|||||||.|::|||||||.|||.::||.......||:||:|||||:
Worm   131 LIELRESDG--VDIASEKGIQYFLDRFYINRISIRMLQNQHLVVFGNVLPESPRHVGCIDPACDV 193

  Fly   199 SDVVRDAYENARFLCDQYYLTSPALEIQQHSS-EPGDNLPIRTVYVPSHLYYMLFELFKNSMRAV 262
            ..||.||:||||||||:||||||:::::.|:: |.|.  ||..|.||||||:|:||||||:|||.
Worm   194 ESVVYDAFENARFLCDRYYLTSPSMKLEMHNAVEKGK--PISIVAVPSHLYHMMFELFKNAMRAT 256

  Fly   263 VEHHGHDNNDTLPPLKVAICKGKEDICVKISDQGGGIPRSQTDQLFKYMYSTAPQPSKSDLHTVP 327
            ||:||.|  |.||.:||.:.||:||:.:||.|:|||:.|:..::|:.|||||||.|.: |....|
Worm   257 VEYHGVD--DDLPDIKVYVVKGQEDLSIKICDRGGGVSRTILERLYNYMYSTAPPPPR-DGTQAP 318

  Fly   328 LAGYGYGLPISRLYARYFHGDIVLLSCEGFGTDAIIYLKALSDEANELLPIFNKTSSKFYRATVP 392
            |||||||||:||||||||.||:.|:|.||.||||.|||||:..||:|:|||::.:|.:.......
Worm   319 LAGYGYGLPLSRLYARYFLGDLFLVSMEGHGTDACIYLKAVPVEASEVLPIYSTSSRRNLTMGPQ 383

  Fly   393 TGDWSN 398
            ..|||:
Worm   384 VADWSH 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdk	NP_001097240.1	BCDHK_Adom3	32..193	CDD:402181	77/160 (48%)
Pdk	NP_001097240.1	HATPase_PDK-like	197..366	CDD:340406	102/169 (60%)
pdhk-2	NP_498928.1	BCDHK_Adom3	30..188	CDD:287417	77/159 (48%)
		BaeS	<226..365	CDD:223715	87/143 (61%)
		HATPase_c	238..357	CDD:214643	76/121 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159410
Domainoid	1	1.000	160	1.000	Domainoid score	I2482
eggNOG	1	0.900	-	-		E1_COG0642
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55897
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1049
Isobase	1	0.950	-	0	Normalized mean entropy	S1736
OMA	1	1.010	-	-		QHG56575
OrthoDB	1	1.010	-	-		D1242599at2759
OrthoFinder	1	1.000	-	-		FOG0000382
OrthoInspector	1	1.000	-	-		oto17577
orthoMCL	1	0.900	-	-		OOG6_100725
Panther	1	1.100	-	-	LDO	PTHR11947
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R894
SonicParanoid	1	1.000	-	-		X391
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	16.790