DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pdk and pdk1

DIOPT Version :9

Sequence 1:	NP_001097240.1	Gene:	Pdk / 35970	FlyBaseID:	FBgn0017558	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	XP_002934664.2	Gene:	pdk1 / 100497838	XenbaseID:	XB-GENE-483609	Length:	412	Species:	Xenopus tropicalis

Alignment Length:	414	Identity:	228/414 - (55%)
Similarity:	297/414 - (71%)	Gaps:	19/414 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRLFPVRFSAASSSMASLAKMLDFYSGFNPSPLSIKQFMDFGQ-NACEKKSYIFLRKELPVRLAN 64
            |||......:|..:.::...::||||.|:|||||:|||:|||. |||||.|:||||.||||||||
Frog     1 MRLLRALMRSAPLASSNTPSLVDFYSKFSPSPLSMKQFLDFGSVNACEKTSFIFLRHELPVRLAN 65

  Fly    65 IMKEIALLPDNLLHTRSVSEVSSWYVKSFEDVLVYE--KAEPTHDNLQKFVADLDLIRNRHNDVV 127
            |||||.|||||||...|:..|.||||:||::::.::  .||.. |.::||...:..||||||||:
Frog    66 IMKEINLLPDNLLKMPSIKLVQSWYVQSFQEIIDFKDNNAEDP-DTVRKFSDTVITIRNRHNDVI 129

  Fly   128 QTMAQGVIEMKENEGGQVDAPTESSIQYFLDRLYMSRISIRMLINQHTLLFGG----NPHAGGRH 188
            .||||||:|.|::.|  ||..|..::||||||.||||||||||:|||||||||    || |..:|
Frog   130 PTMAQGVVEYKDSFG--VDPVTSQNVQYFLDRFYMSRISIRMLLNQHTLLFGGKVKVNP-AHPKH 191

  Fly   189 IGCLDPACDLSDVVRDAYENARFLCDQYYLTSPALEIQQ-HSSEPGDNLPIRTVYVPSHLYYMLF 252
            ||.:||||::.|||:|.||||:.|||.||::||.:|:.: ::..||.  ||:.||||||||:|:|
Frog   192 IGSIDPACNVVDVVKDGYENAKHLCDLYYMSSPEVELTEFNAKSPGQ--PIQVVYVPSHLYHMVF 254

  Fly   253 ELFKNSMRAVVEHHGHDNNDTLPPLKVAICKGKEDICVKISDQGGGIPRSQTDQLFKYMYSTAPQ 317
            |||||:|||.:|.|.  :....|.:||.:..|.||:.:|:||:|||:|..:.|:||.|||||||.
Frog   255 ELFKNAMRATMEFHA--DKGVYPSVKVHVVLGSEDLTIKLSDRGGGVPLRKIDRLFNYMYSTAPL 317

  Fly   318 PSKSDLHTVPLAGYGYGLPISRLYARYFHGDIVLLSCEGFGTDAIIYLKALSDEANELLPIFNKT 382
            |........||||:|||||||||||:||.||:.|.|.||:||||:||.||||.|:.|.||::||:
Frog   318 PRMETSRATPLAGFGYGLPISRLYAKYFQGDLKLYSLEGYGTDAVIYFKALSTESIERLPVYNKS 382

  Fly   383 SSKFYRATVPTGDW---SNQSSDM 403
            :.|.|:......||   |::..||
Frog   383 AWKHYKTNHEADDWCVPSSEPKDM 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdk	NP_001097240.1	BCDHK_Adom3	32..193	CDD:402181	103/167 (62%)
Pdk	NP_001097240.1	HATPase_PDK-like	197..366	CDD:340406	93/169 (55%)
pdk1	XP_002934664.2	BCDHK_Adom3	32..196	CDD:371050	103/167 (62%)
pdk1	XP_002934664.2	HATPase_PDK-like	200..366	CDD:340406	93/169 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	185	1.000	Domainoid score	I3319
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	439	1.000	Inparanoid score	I1628
OMA	1	1.010	-	-		QHG56575
OrthoDB	1	1.010	-	-		D1242599at2759
OrthoFinder	1	1.000	-	-		FOG0000382
OrthoInspector	1	1.000	-	-		otm47583
Panther	1	1.100	-	-	O	PTHR11947
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R894
SonicParanoid	1	1.000	-	-		X391
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.110