DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wun and PLPP2

DIOPT Version :9

Sequence 1:	NP_724787.1	Gene:	wun / 35966	FlyBaseID:	FBgn0016078	Length:	379	Species:	Drosophila melanogaster
Sequence 2:	NP_808211.1	Gene:	PLPP2 / 8612	HGNCID:	9230	Length:	309	Species:	Homo sapiens

Alignment Length:	282	Identity:	109/282 - (38%)
Similarity:	161/282 - (57%)	Gaps:	27/282 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 LCAGFPILLFFLLGEPYKRGFFCDDESLKHPFHDSTVRNWMLYFIGAVIPVGVIFIVEVIISQNK 162
            |.|..|..:..|:..||||||:|.|:|:::|:...|:.:.::  .|..|...||     ::|..:
Human    37 LGASLPFAILTLVNAPYKRGFYCGDDSIRYPYRPDTITHGLM--AGVTITATVI-----LVSAGE 94

  Fly   163 AKQDNGNATSRRYVFMNYELPDWMIECYKKIGIYAFGAVLSQLTTDIAKYSIGRLRPHFIAVCQP 227
            |.....:....|..|.||     :...||.:|.:.|||.:||..||:|||.||||||:|:|||.|
Human    95 AYLVYTDRLYSRSDFNNY-----VAAVYKVLGTFLFGAAVSQSLTDLAKYMIGRLRPNFLAVCDP 154

  Fly   228 QMADGSTCDDAINAGKYIQ-EFTCKGVGSSARMLKEMRLSFPSGHSSFTFFAMVYLALYLQARMT 291
            ..:       .:|...|:| |..|:|   :...:.|.||||.||||||..:.||:||||:|||:.
Human   155 DWS-------RVNCSVYVQLEKVCRG---NPADVTEARLSFYSGHSSFGMYCMVFLALYVQARLC 209

  Fly   292 WRGSKLLRHLLQFLFIMVAWYTALSRVSDYKHHWSDVLAGSLIGSISALVVANYVSDLFQ-KPNT 355
            |:.::|||..:||..:..|.|...:|||||||||||||.|.|.|::.|.:...|:||.|: :|
Human   210 WKWARLLRPTVQFFLVAFALYVGYTRVSDYKHHWSDVLVGLLQGALVAALTVCYISDFFKARP-- 272

  Fly   356 KPYLARTVQDMNASPAQAITIT 377
             |......:::...|:.::|:|
Human   273 -PQHCLKEEELERKPSLSLTLT 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wun	NP_724787.1	PAP2_wunen	188..343	CDD:239479	75/155 (48%)
PLPP2	NP_808211.1	PAP2_wunen	115..261	CDD:239479	75/155 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144681
Domainoid	1	1.000	156	1.000	Domainoid score	I4177
eggNOG	1	0.900	-	-		E1_COG0671
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	204	1.000	Inparanoid score	I3741
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48083
OrthoDB	1	1.010	-	-		D434801at33208
OrthoFinder	1	1.000	-	-		FOG0000694
OrthoInspector	1	1.000	-	-		mtm8567
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10165
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X571
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.870