DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wun and PLPP1

DIOPT Version :9

Sequence 1:	NP_724787.1	Gene:	wun / 35966	FlyBaseID:	FBgn0016078	Length:	379	Species:	Drosophila melanogaster
Sequence 2:	NP_795714.1	Gene:	PLPP1 / 8611	HGNCID:	9228	Length:	285	Species:	Homo sapiens

Alignment Length:	272	Identity:	122/272 - (44%)
Similarity:	166/272 - (61%)	Gaps:	23/272 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 NKRILCRVGLDVLILLCAGFPILLFFLLGE--PYKRGFFCDDESLKHPFHDSTVRNWMLYFIGAV 145
            :|..|..|.||||.:|.|..|:.: ..||:  |::|||||.|.|:.:|:|||||.:.:|..:|..
Human     3 DKTRLPYVALDVLCVLLASMPMAV-LKLGQIYPFQRGFFCKDNSINYPYHDSTVTSTVLILVGVG 66

  Fly   146 IPVGVIFIVEVIISQNKAKQDNGNATSRRYVFMNYELPDWMIECYKKIGIYAFGAVLSQLTTDIA 210
            :|:..|.:.|.:.........|.      ::..||     :...||.||.:.|||..||..||||
Human    67 LPISSIILGETLSVYCNLLHSNS------FIRNNY-----IATIYKAIGTFLFGAAASQSLTDIA 120

  Fly   211 KYSIGRLRPHFIAVCQPQMADGSTCDDAINAGKYIQEFTCKGVGSSARMLKEMRLSFPSGHSSFT 275
            |||||||||||:.||.|..:. ..|.|.     ||:.:.|:|   :|..:||.||||.||||||:
Human   121 KYSIGRLRPHFLDVCDPDWSK-INCSDG-----YIEYYICRG---NAERVKEGRLSFYSGHSSFS 176

  Fly   276 FFAMVYLALYLQARMTWRGSKLLRHLLQFLFIMVAWYTALSRVSDYKHHWSDVLAGSLIGSISAL 340
            .:.|:::||||||||....::|||..|||..:.|:.|..|||||||||||||||.|.:.|::.|:
Human   177 MYCMLFVALYLQARMKGDWARLLRPTLQFGLVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVAI 241

  Fly   341 VVANYVSDLFQK 352
            :||.||||.|::
Human   242 LVAVYVSDFFKE 253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wun	NP_724787.1	PAP2_wunen	188..343	CDD:239479	81/154 (53%)
PLPP1	NP_795714.1	PAP2_wunen	99..244	CDD:239479	81/153 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144637
Domainoid	1	1.000	156	1.000	Domainoid score	I4177
eggNOG	1	0.900	-	-		E1_COG0671
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7484
Inparanoid	1	1.050	204	1.000	Inparanoid score	I3741
Isobase	1	0.950	-	0	Normalized mean entropy	S2766
OMA	1	1.010	-	-		QHG48083
OrthoDB	1	1.010	-	-		D1354951at2759
OrthoFinder	1	1.000	-	-		FOG0000694
OrthoInspector	1	1.000	-	-		mtm8567
orthoMCL	1	0.900	-	-		OOG6_100228
Panther	1	1.100	-	-	LDO	PTHR10165
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3374
SonicParanoid	1	1.000	-	-		X571
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750