DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wun and SGPP1

DIOPT Version :9

Sequence 1:	NP_724787.1	Gene:	wun / 35966	FlyBaseID:	FBgn0016078	Length:	379	Species:	Drosophila melanogaster
Sequence 2:	NP_110418.1	Gene:	SGPP1 / 81537	HGNCID:	17720	Length:	441	Species:	Homo sapiens

Alignment Length:	228	Identity:	48/228 - (21%)
Similarity:	71/228 - (31%)	Gaps:	72/228 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 VRNWMLYFIGAVIPVGVIFIVEVIISQNKAKQDNGNATSRRYVFMNYELPDWMIECYKKIG---- 194
            |.||.||.:       ..|..|:           ||.     :|.....|.|:......:|
Human   123 VSNWPLYCL-------FCFGTEL-----------GNE-----LFYILFFPFWIWNLDPLVGRRLV 164

  Fly   195 -IYAFGAVLSQLTTDIAKYSIGRLRPHFIAVCQPQMADGSTCDDAINAGKYIQEFTCKGVGSSAR 258
             |:.....|.|.|.||.::.    ||....|.:.::.             |..|:
Human   165 VIWVLVMYLGQCTKDIIRWP----RPASPPVVKLEVF-------------YNSEY---------- 202

  Fly   259 MLKEMRLSFPSGHSSFTFFAMVYLALYLQARMTWRGSKLLRHLLQFLFIMVAW--YTALSRVSDY 321
                   |.||.|:.......:.:.|....|  |:     ..|:..|.::..|  ...|||:...
Human   203 -------SMPSTHAMSGTAIPISMVLLTYGR--WQ-----YPLIYGLILIPCWCSLVCLSRIYMG 253

  Fly   322 KHHWSDVLAGSLIGSISALVVANYVSDLFQKPN 354
            .|...|::||.|. :|..|.|.....||....|
Human   254 MHSILDIIAGFLY-TILILAVFYPFVDLIDNFN 285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wun	NP_724787.1	PAP2_wunen	188..343	CDD:239479	32/161 (20%)
SGPP1	NP_110418.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..110
		PAP2_SPPase1	126..275	CDD:239482	43/213 (20%)
		Phosphatase sequence motif I. /evidence=ECO:0000305	178..186		2/11 (18%)
		Phosphatase sequence motif II. /evidence=ECO:0000305	205..208		2/2 (100%)
		Phosphatase sequence motif III. /evidence=ECO:0000305	248..259		3/10 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0671
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900