DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wun and PLPP4

DIOPT Version :9

Sequence 1:	NP_724787.1	Gene:	wun / 35966	FlyBaseID:	FBgn0016078	Length:	379	Species:	Drosophila melanogaster
Sequence 2:	NP_001025230.1	Gene:	PLPP4 / 196051	HGNCID:	23531	Length:	271	Species:	Homo sapiens

Alignment Length:	290	Identity:	77/290 - (26%)
Similarity:	121/290 - (41%)	Gaps:	58/290 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 KRILCRVGLDVLILLCAGFPILLFFLLGEPYKRGFFCDDESL-KHPFHDS-TVRNWMLYFIGAVI 146
            :.:...:|:..|:     |.:.:|....:|::|....::..| |:|...| .:...:::.|..:.
Human     2 RELAIEIGVRALL-----FGVFVFTEFLDPFQRVIQPEEIWLYKNPLVQSDNIPTRLMFAISFLT 61

  Fly   147 PVGVIFIVEVIISQNKAKQDNGNATSRRYVFMNYELPDWMIECYKKIGIYAFGAVLSQLTTDIAK 211
            |:.||.:|::|...:|        |..:..|:...|                ...|:.:.|:..|
Human    62 PLAVICVVKIIRRTDK--------TEIKEAFLAVSL----------------ALALNGVCTNTIK 102

  Fly   212 YSIGRLRPHFIAVCQPQMADGSTCDDAINAGKYIQEFTCKGVGSSARMLKEMRLSFPSGHSSFTF 276
            ..:||.||.|...|.|        |..:|:     |..|.|   ...::.|.|.||||.||||.|
Human   103 LIVGRPRPDFFYRCFP--------DGVMNS-----EMHCTG---DPDLVSEGRKSFPSIHSSFAF 151

  Fly   277 FAMVYLALYLQARM-----TWRGSKLLRHLLQFLFIMVAWYTALSRVSDYKHHWSDVLAGSLIGS 336
            ..:.:...||..::     :.|| |..|.....|.:..|...||||:.||||||.|...|.:||.
Human   152 SGLGFTTFYLAGKLHCFTESGRG-KSWRLCAAILPLYCAMMIALSRMCDYKHHWQDSFVGGVIGL 215

  Fly   337 ISALVVANYVSDLFQKPNT---KPYLARTV 363
            |.|.:.  |........||   |||::..|
Human   216 IFAYIC--YRQHYPPLANTACHKPYVSLRV 243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wun	NP_724787.1	PAP2_wunen	188..343	CDD:239479	50/159 (31%)
PLPP4	NP_001025230.1	PAP2_containing_1_like	37..225	CDD:239484	65/230 (28%)
		Phosphatase sequence motif I. /evidence=ECO:0000269\|PubMed:17590538	102..110		3/7 (43%)
		Phosphatase sequence motif II. /evidence=ECO:0000269\|PubMed:17590538	143..146		2/2 (100%)
		Phosphatase sequence motif III. /evidence=ECO:0000269\|PubMed:17590538	195..205		7/9 (78%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..271
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144667
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0671
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100228
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3374
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.670