DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Non1 and nog1

DIOPT Version :9

Sequence 1:	NP_001286247.1	Gene:	Non1 / 35963	FlyBaseID:	FBgn0028473	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001342776.1	Gene:	nog1 / 2541126	PomBaseID:	SPBC651.01c	Length:	642	Species:	Schizosaccharomyces pombe

Alignment Length:	650	Identity:	325/650 - (50%)
Similarity:	440/650 - (67%)	Gaps:	16/650 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FKKIMVVPPAKDFIDIMLSKTQRKTPTVVHKGYKISRIRAFYTRKVKYTQQNFHDRLSQIIQDFP 70
            ||.|..:|....|:|::||:||||||||:..|:||||||.||.||||:||....::|..|:|:||
pombe     6 FKNITPIPDVNTFLDVVLSRTQRKTPTVIRSGFKISRIRGFYGRKVKFTQDTITEKLDSILQEFP 70

  Fly    71 KLDDVHPFYADLMNVLYDKDHYKLALGQLNTARHLVDNVAKDYVRLLKYGDSLYRCKQLKKAALG 135
            ||:|:|||:|||:|:|||:||.|:||.||:||:|||:|||:||:||||||||||||||||:||||
pombe    71 KLNDIHPFHADLLNILYDRDHLKIALSQLSTAKHLVENVARDYIRLLKYGDSLYRCKQLKRAALG 135

  Fly   136 RMATIMKRQASNLTYLEQVRQHLSRLPTIDPYSRTIIICGFPNVGKSSFINKITRADVEVQPYAF 200
            |||||:|||.|:|.:||||||||||||.|||.:||:::||:||||||||:||:|||.|:||||||
pombe   136 RMATIIKRQKSSLEFLEQVRQHLSRLPAIDPNTRTLLVCGYPNVGKSSFMNKVTRAQVDVQPYAF 200

  Fly   201 TTKSLYVGHTDYKYLRWQVIDTPGILDHPLEERNVIEMQAITALAHLRACVLYFMDISEQCGHSL 265
            |||||:|||.|||||||||||||||||||||:.|.||||:|||:||||:.||||||:||.||:|:
pombe   201 TTKSLFVGHFDYKYLRWQVIDTPGILDHPLEQMNTIEMQSITAMAHLRSAVLYFMDLSEMCGYSV 265

  Fly   266 EEQVKLFESIKPLFTNKPLILAINKIDILTPEDLPEERRAIITKLQEDKNIPVMLMSTVQETGVM 330
            ..||||:.||||||.||..||.:||||.:.||||.::.:.::..:.:|.|:.|:..|.||:.|||
pombe   266 AAQVKLYHSIKPLFANKVTILVLNKIDAMRPEDLDQKNQELLQTIIDDGNVKVVQTSCVQDIGVM 330

  Fly   331 EVKTEACERLLSYRVDQKMRTKKVDNILNRLHVAMPAPRDDKLRAPCIPEKASARLLQNADKAER 395
            :|:|.|||.||:.||:||::..:|:|:|||:|:|.||.||:..|..|||:....|...:|:...|
pombe   331 DVRTTACEALLAARVEQKLKGSRVNNVLNRIHLAEPAARDEVARPACIPDSVKTRRAYDANDPNR 395

  Fly   396 KRKLEKEIEEEMGDD--YTLDLKKNYSEIPEEERYDIIPEFWQGHNIADYIDADIFDKLEELERE 458
             |.|.::||...|..  |.::|:..|.......:||.:||...|.|:||::|.:|..||..|:.|
pombe   396 -RILARDIEAANGGAGVYNVELRDKYILQDPSWKYDRMPELLDGKNVADFVDPEIEAKLLALDEE 459

  Fly   459 EGLREESGVYKVPDMTMDETLKEIREIAKQIRGKRFELRDEKRLSSRKNKPVIPRNKQPKVRDRS 523
            |...|..|.|.......|...:|:.|.|.:||.|........|....||:||:||.    ...|:
pombe   460 EERLEREGYYDSDQEIEDADEEEVLEKASRIREKNKLTMLAARQKKIKNRPVLPRT----AGIRT 520

  Fly   524 VQKLVSTMEGLGVDMSGSENANFTKSVVDLRRGQVAVGSKKVPMQPLLDKESSAVVRKTGQPLKR 588
            :.:|.|:::..|:.....|....:::.. ....::|.||.    ..||..|...:..|:..|..:
pombe   521 LDELQSSLQSAGLPSDSIEERARSRART-AAANEMADGSG----VDLLMNEGEEIRSKSIAPRSQ 580

  Fly   589 APSRDTLGIKNLAIRKKAQIMAK-RDIAKKVTSRGLKGEADRFIGTKMPKHLFSGKRGNGKTDRR 652
            :..|:: |:.....|..|..:|: :.|.:...:|.  .|:||.:....||||.|||||||||.||
pombe   581 SNRRES-GVHAEGARSYADRLARVKQIHRNRMARA--SESDRHVIAAKPKHLLSGKRGNGKTQRR 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Non1	NP_001286247.1	Nog1	5..341	CDD:224009	223/334 (67%)
		NOG	169..341	CDD:206684	112/171 (65%)
		NOGCT	398..448	CDD:285381	16/51 (31%)
nog1	NP_001342776.1	Nog1	2..346	CDD:224009	226/339 (67%)
nog1	NP_001342776.1	NOGCT	398..449	CDD:311880	16/50 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	240	1.000	Domainoid score	I458
eggNOG	1	0.900	-	-		E1_COG1084
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7100
Inparanoid	1	1.050	611	1.000	Inparanoid score	I153
OMA	1	1.010	-	-		QHG53775
OrthoFinder	1	1.000	-	-		FOG0003703
OrthoInspector	1	1.000	-	-		oto101882
orthoMCL	1	0.900	-	-		OOG6_101289
Panther	1	1.100	-	-	LDO	PTHR45759
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R823
SonicParanoid	1	1.000	-	-		X3064
TreeFam	1	0.960	-	-
	14	13.860