DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Non1 and GTPBP4

DIOPT Version :9

Sequence 1:	NP_001286247.1	Gene:	Non1 / 35963	FlyBaseID:	FBgn0028473	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_036473.2	Gene:	GTPBP4 / 23560	HGNCID:	21535	Length:	634	Species:	Homo sapiens

Alignment Length:	663	Identity:	390/663 - (58%)
Similarity:	485/663 - (73%)	Gaps:	40/663 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLYNFKKIMVVPPAKDFIDIMLSKTQRKTPTVVHKGYKISRIRAFYTRKVKYTQQNFHDRLSQI 65
            |:.||||||.|||.||||||:.|||||||||||:||.|:|.|||.||.||||:||||:|||||||
Human     1 MAHYNFKKITVVPSAKDFIDLTLSKTQRKTPTVIHKHYQIHRIRHFYMRKVKFTQQNYHDRLSQI 65

  Fly    66 IQDFPKLDDVHPFYADLMNVLYDKDHYKLALGQLNTARHLVDNVAKDYVRLLKYGDSLYRCKQLK 130
            :.|||||||:|||||||||:|||||||||||||:|.|::||||||||||||:|||||||||||||
Human    66 LTDFPKLDDIHPFYADLMNILYDKDHYKLALGQINIAKNLVDNVAKDYVRLMKYGDSLYRCKQLK 130

  Fly   131 KAALGRMATIMKRQASNLTYLEQVRQHLSRLPTIDPYSRTIIICGFPNVGKSSFINKITRADVEV 195
            :||||||.|::|||..:|.|||||||||||||||||.:||:::||:|||||||||||:|||||:|
Human   131 RAALGRMCTVIKRQKQSLEYLEQVRQHLSRLPTIDPNTRTLLLCGYPNVGKSSFINKVTRADVDV 195

  Fly   196 QPYAFTTKSLYVGHTDYKYLRWQVIDTPGILDHPLEERNVIEMQAITALAHLRACVLYFMDISEQ 260
            ||||||||||:|||.|||||||||:|||||||||||:||.||||||||||||||.|||.||:|||
Human   196 QPYAFTTKSLFVGHMDYKYLRWQVVDTPGILDHPLEDRNTIEMQAITALAHLRAAVLYVMDLSEQ 260

  Fly   261 CGHSLEEQVKLFESIKPLFTNKPLILAINKIDILTPEDLPEERRAIITKLQEDKNIPVMLMSTVQ 325
            |||.|.||::||::|:|||.|||||:..||.|:....:|.|:.:.|.|.||.: ..||:..||:.
Human   261 CGHGLREQLELFQNIRPLFINKPLIVVANKCDVKRIAELSEDDQKIFTDLQSE-GFPVIETSTLT 324

  Fly   326 ETGVMEVKTEACERLLSYRVDQKMRTKKVDNILNRLHVAMPAPRDDKLRAPCIPEKASARLLQNA 390
            |.||::||||||:|||::||:.||:..||:.:|||||:|:|..||||.|.|.|||...|| .:..
Human   325 EEGVIKVKTEACDRLLAHRVETKMKGNKVNEVLNRLHLAIPTRRDDKERPPFIPEGVVAR-RKRM 388

  Fly   391 DKAERKRKLEKEIEEEMGDDYTLDLKKNYSEIPEEERYDIIPEFWQGHNIADYIDADIFDKLEEL 455
            :..|.::|.|:::|.||||||.|||:|.:..:...|::|.|||.|:|||||||||..|..|||||
Human   389 ETEESRKKRERDLELEMGDDYILDLQKYWDLMNLSEKHDKIPEIWEGHNIADYIDPAIMKKLEEL 453

  Fly   456 EREEGLREESGVYKVPDMTMDETLKEIREIAKQIRGKRFELRDEKRL----SSRKNK--PVIPRN 514
            |:||.||..:|.|.....:.||.:.|||::||||       |::|:|    |..||.  |.:||.
Human   454 EKEEELRTAAGEYDSVSESEDEEMLEIRQLAKQI-------REKKKLKILESKEKNTQGPRMPRT 511

  Fly   515 KQPKVRDRSVQKLV--STMEGLGVDMSGSENANFTKSVVDLRRGQVAVGSKKVPMQPLLDKESSA 577
            .      :.||:.|  ..|..|||||...::|::   .|..||.:.....:|        :|.||
Human   512 A------KKVQRTVLEKEMRSLGVDMDDKDDAHY---AVQARRSRSITRKRK--------REDSA 559

  Fly   578 ---VVRKTGQPLKRAPSRDTLGIKNLAIRKKAQIMAKRDIAKKVTSRGLKGEADRFIGTKMPKHL 639
               .|.::|. ..|.| ||..|::::.:.|||:.|.| :..||:...|.||||||.:....||||
Human   560 PPSSVARSGS-CSRTP-RDVSGLRDVKMVKKAKTMMK-NAQKKMNRLGKKGEADRHVFDMKPKHL 621

  Fly   640 FSGKRGNGKTDRR 652
            .||||..||.|||
Human   622 LSGKRKAGKKDRR 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Non1	NP_001286247.1	Nog1	5..341	CDD:224009	251/335 (75%)
		NOG	169..341	CDD:206684	118/171 (69%)
		NOGCT	398..448	CDD:285381	28/49 (57%)
GTPBP4	NP_036473.2	Nog1	5..345	CDD:224009	254/340 (75%)
		NOGCT	398..446	CDD:400463	27/47 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	495..517		7/27 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	529..634		43/118 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160321
Domainoid	1	1.000	277	1.000	Domainoid score	I1743
eggNOG	1	0.900	-	-		E1_COG1084
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7100
Inparanoid	1	1.050	733	1.000	Inparanoid score	I608
Isobase	1	0.950	-	0	Normalized mean entropy	S500
OMA	1	1.010	-	-		QHG53775
OrthoDB	1	1.010	-	-		D338191at33208
OrthoFinder	1	1.000	-	-		FOG0003703
OrthoInspector	1	1.000	-	-		oto91222
orthoMCL	1	0.900	-	-		OOG6_101289
Panther	1	1.100	-	-	LDO	PTHR45759
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R823
SonicParanoid	1	1.000	-	-		X3064
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750