DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Non1 and nog-1

DIOPT Version :9

Sequence 1:	NP_001286247.1	Gene:	Non1 / 35963	FlyBaseID:	FBgn0028473	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_741288.1	Gene:	nog-1 / 176863	WormBaseID:	WBGene00020297	Length:	681	Species:	Caenorhabditis elegans

Alignment Length:	703	Identity:	356/703 - (50%)
Similarity:	473/703 - (67%)	Gaps:	76/703 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SLYNFKKIMVVPPAKDFIDIMLSKTQRKTPTVVHKGYKISRIRAFYTRKVKYTQQNFHDRLSQII 66
            |:||||:|..||.|::..|::|||||||||||||:.|.|.||||||.||:|:.||..||:|:|||
Worm     3 SMYNFKRITCVPNAQELKDVVLSKTQRKTPTVVHRQYSIGRIRAFYARKIKFLQQTLHDKLTQII 67

  Fly    67 QDFPKLDDVHPFYADLMNVLYDKDHYKLALGQLNTARHLVDNVAKDYVRLLKYGDSLYRCKQLKK 131
            .:|||::::||||:||||:|||:||||:||||:||||||:|.:|::||||:||.|||||||.||:
Worm    68 TEFPKMEEIHPFYSDLMNILYDRDHYKIALGQMNTARHLIDGIAREYVRLMKYADSLYRCKMLKR 132

  Fly   132 AALGRMATIMKRQASNLTYLEQVRQHLSRLPTIDPYSRTIIICGFPNVGKSSFINKITRADVEVQ 196
            ||||||..::|||.|:..|||||||||||||:|||.:||:|:|||||||||||||.:||||||||
Worm   133 AALGRMVKLLKRQKSSFEYLEQVRQHLSRLPSIDPATRTLILCGFPNVGKSSFINNVTRADVEVQ 197

  Fly   197 PYAFTTKSLYVGHTDYKYLRWQVIDTPGILDHPLEERNVIEMQAITALAHLRACVLYFMDISEQC 261
            |||||||:|||||.||::|||||||||||||.|||:||.|||||:||||||:|.||:.||:||||
Worm   198 PYAFTTKALYVGHLDYRFLRWQVIDTPGILDQPLEDRNTIEMQAVTALAHLKASVLFMMDVSEQC 262

  Fly   262 GHSLEEQVKLFESIKPLFTNKPLILAINKIDILTPEDLPEERRAIITKLQEDKNIPVMLMSTVQE 326
            ..|:|||:.|||||:|||.|||:::.:||:||....|||.|:.|::.:| |.:.||::..||:.:
Worm   263 DRSIEEQLHLFESIRPLFANKPVLIGLNKVDIRHRSDLPPEKAALLDQL-EKEGIPIIETSTLTQ 326

  Fly   327 TGVMEVKTEACERLLSYRVDQKMRTKKVDN----ILNRLHVAMPAPRDDKLRAPCIP----EKAS 383
            .|||.::..||:.||:.||:.|::.||:.|    :|||:.||.|||||:|:|||.:|    .|.:
Worm   327 EGVMGLRDRACDELLAQRVEAKIQAKKITNVEDCVLNRVFVAYPAPRDEKVRAPFVPPGLAAKRA 391

  Fly   384 ARLLQNAD---------------------------------------KAERKRKLEKEIEEEMGD 409
            .:.||.|.                                       :.|..|:||:|||.||.|
Worm   392 QKKLQEAQELMETDGDEFAAKIPQKPGKIGKEKIAKGGSQSTDLGDLRDENTRRLEREIELEMQD 456

  Fly   410 DYTLDLKKNYSEIPEEERYDIIPEFWQGHNIADYIDADIFDKLEELEREEGLREESGVYKVPDMT 474
            ||.|||||:|.....:|:|||:||.|:|||:||::|.:|..|||.|.|||.|.|::|.|:....:
Worm   457 DYILDLKKHYMLKNPDEKYDIVPEIWEGHNLADFVDPEIQSKLENLLREEELLEQAGEYESDLDS 521

  Fly   475 MDETLKEIREIAKQIRGKRFELRDEKRLSSRKNKPVIPRNKQPKVRDRSVQKLVSTMEGLGVDMS 539
            .||..||..::|.|||.|...|..:..::.|....:..|....:.||||:.:|.:.:..||||:.
Worm   522 DDEETKEKLKLALQIREKEKLLTLDHAVNKRIAGRIGSRIHGSRKRDRSMSRLENELGELGVDVD 586

  Fly   540 GSENANFTKSVVDLRRGQVAVGSKKVPMQPLLDKESSAVVRKTGQPLKRAPSRDTLGIKNLAIRK 604
                   ||.:.:| :||.|        :|.|.|:......::...::.|| ||.|...:  ..|
Worm   587 -------TKKMKNL-QGQCA--------KPQLGKKMKVGRSRSLSAVRPAP-RDELAFPD--EEK 632

  Fly   605 KAQIMAKRDIAKKVTSRGL-----KGEADRFIGTKMPKHLFSGKRGNGKTDRR 652
            :|.:    |..:....|||     ||||||.:....|||||.|||||||||.|
Worm   633 RAHV----DKLRTKAMRGLRREAKKGEADRHVYDLKPKHLFCGKRGNGKTDWR 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Non1	NP_001286247.1	Nog1	5..341	CDD:224009	222/335 (66%)
		NOG	169..341	CDD:206684	111/171 (65%)
		NOGCT	398..448	CDD:285381	29/49 (59%)
nog-1	NP_741288.1	Nog1	3..346	CDD:224009	227/343 (66%)
		NOG	170..341	CDD:206684	111/171 (65%)
		NOGCT	445..495	CDD:285381	29/49 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167755
Domainoid	1	1.000	245	1.000	Domainoid score	I1213
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7100
Inparanoid	1	1.050	646	1.000	Inparanoid score	I432
Isobase	1	0.950	-	0	Normalized mean entropy	S500
OMA	1	1.010	-	-		QHG53775
OrthoDB	1	1.010	-	-		D338191at33208
OrthoFinder	1	1.000	-	-		FOG0003703
OrthoInspector	1	1.000	-	-		oto20032
orthoMCL	1	0.900	-	-		OOG6_101289
Panther	1	1.100	-	-	LDO	PTHR45759
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R823
SonicParanoid	1	1.000	-	-		X3064
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.890