DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8800 and PPP1R7

DIOPT Version :9

Sequence 1:	NP_610483.1	Gene:	CG8800 / 35962	FlyBaseID:	FBgn0033408	Length:	188	Species:	Drosophila melanogaster
Sequence 2:	NP_002703.1	Gene:	PPP1R7 / 5510	HGNCID:	9295	Length:	360	Species:	Homo sapiens

Alignment Length:	162	Identity:	48/162 - (29%)
Similarity:	82/162 - (50%)	Gaps:	30/162 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 IEKMDSTLGTLVQCERISMSTNMIEKIFGLSGMKCLKVLSLSRNYIKQISGLEAVAETLEELWLS 101
            ||.:|    ||...|.:.:..|.|.|:..|..:..|.|||:..|.:.:|.||:.:. .|.||:||
Human   201 IENID----TLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLV-NLRELYLS 260

  Fly   102 YNLIEKIKGL----------------------TGLKCLKVLYISNNLIKDWSEFNRLAEIESLED 144
            :|.||.|:||                      :.|..|:..::::||::.||:.:.|....|||.
Human   261 HNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGARSLET 325

  Fly   145 LVVVGNPLSEGLDEPTWRAECIKRLPTIRKLD 176
            :.:..|||.:   :|.:|.:.:..||::|::|
Human   326 VYLERNPLQK---DPQYRRKVMLALPSVRQID 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8800	NP_610483.1	PPP1R42	37..180	CDD:411060	48/162 (30%)
		leucine-rich repeat	50..71	CDD:275380	5/20 (25%)
		leucine-rich repeat	95..116	CDD:275380	12/42 (29%)
		leucine-rich repeat	117..141	CDD:275380	6/23 (26%)
PPP1R7	NP_002703.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..64
		LRR 1	77..98
		internalin_A	87..>317	CDD:380193	35/120 (29%)
		LRR 2	99..120
		leucine-rich repeat	100..121	CDD:275380
		LRR 3	121..142
		leucine-rich repeat	122..143	CDD:275380
		LRR 4	143..164
		leucine-rich repeat	144..165	CDD:275380
		LRR 5	165..186
		leucine-rich repeat	166..187	CDD:275380
		LRR 6	187..208		4/10 (40%)
		leucine-rich repeat	188..209	CDD:275380	5/11 (45%)
		LRR 7	209..230		5/20 (25%)
		leucine-rich repeat	210..231	CDD:275380	5/20 (25%)
		LRR 8	231..252		8/20 (40%)
		leucine-rich repeat	232..253	CDD:275380	8/21 (38%)
		LRR 9	253..274		11/20 (55%)
		leucine-rich repeat	254..275	CDD:275380	11/20 (55%)
		LRR 10	275..296		0/20 (0%)
		leucine-rich repeat	276..297	CDD:275380	1/20 (5%)
		LRR 11	297..318		5/20 (25%)
		LRRcap	336..354	CDD:197729	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0531
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810