DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8800 and Cntrl

DIOPT Version :9

Sequence 1:	NP_610483.1	Gene:	CG8800 / 35962	FlyBaseID:	FBgn0033408	Length:	188	Species:	Drosophila melanogaster
Sequence 2:	NP_001366203.1	Gene:	Cntrl / 26920	MGIID:	1889576	Length:	2334	Species:	Mus musculus

Alignment Length:	191	Identity:	55/191 - (28%)
Similarity:	97/191 - (50%)	Gaps:	21/191 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IKEALKRWEEREQQNSLTAKVIDL--------QFQWPPIEKMDSTLGTLVQCERISMSTNMIEKI 63
            |.|||.: :..:|.|....|.::|        :|::  ||.::.    .|:.|.:::|.|:|.||
Mouse    83 ITEALIK-KLTKQDNLALVKSLNLSLSKDGGKKFRY--IENLEK----CVKLEVLNLSYNLIVKI 140

  Fly    64 FGLSGMKCLKVLSLSRNYIKQISGLEAVAETLEELWLSYNLIEKIK--GLTGLKCLKVLYISNNL 126
            ..:..:..|:.|:||.|.|.:|.|||.:. .|::|.|:.|.||.|.  ....||.|:||.:..|.
Mouse   141 EKVDKLLRLRELNLSYNKISKIEGLENMC-NLQKLNLAGNEIEHIPVWFAKKLKSLRVLNLKGNK 204

  Fly   127 IKDWSEFNRLAEIESLEDLVVVGNPLSEGLDEPTWRAECIKRLPTIRKLDGEPVVLNEEPQ 187
            |....:.::|..::.|..||::.||:   :..|.:....|..|.::..|:|:||...:..:
Mouse   205 ISSLQDVSKLKPLQDLTSLVLIDNPV---VALPHYLQFIIFHLRSLESLEGQPVTTQDRQE 262

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8800	NP_610483.1	PPP1R42	37..180	CDD:411060	44/144 (31%)
		leucine-rich repeat	50..71	CDD:275380	6/20 (30%)
		leucine-rich repeat	95..116	CDD:275380	8/22 (36%)
		leucine-rich repeat	117..141	CDD:275380	6/23 (26%)
Cntrl	NP_001366203.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..70
		PPP1R42	89..261	CDD:411060	51/182 (28%)
		leucine-rich repeat	100..119	CDD:275378	3/20 (15%)
		LRR 1	126..147		6/20 (30%)
		leucine-rich repeat	127..148	CDD:275380	6/20 (30%)
		LRR 2	148..169		10/20 (50%)
		leucine-rich repeat	149..170	CDD:275380	10/21 (48%)
		LRR 3	170..191		7/20 (35%)
		leucine-rich repeat	171..194	CDD:275380	8/22 (36%)
		LRR 4	194..215		5/20 (25%)
		leucine-rich repeat	195..219	CDD:275380	6/23 (26%)
		leucine-rich repeat	220..246	CDD:275380	8/28 (29%)
		Smc	<270..602	CDD:224117
		Smc	440..>1134	CDD:224117
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..562
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	751..771
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1154..1198
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1213..1245
		Drf_FH1	<1239..1310	CDD:399386
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1338..1360
		SMC_prok_B	1407..2216	CDD:274008
		Required for centrosome localization. /evidence=ECO:0000250	1951..2121
		Sufficient for interaction with HOOK2. /evidence=ECO:0000250	1988..2334
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2291..2334
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0531
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810