DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8800 and LRRIQ3

DIOPT Version :9

Sequence 1:	NP_610483.1	Gene:	CG8800 / 35962	FlyBaseID:	FBgn0033408	Length:	188	Species:	Drosophila melanogaster
Sequence 2:	NP_001099129.1	Gene:	LRRIQ3 / 127255	HGNCID:	28318	Length:	624	Species:	Homo sapiens

Alignment Length:	192	Identity:	44/192 - (22%)
Similarity:	73/192 - (38%)	Gaps:	45/192 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 TIKEALKRWEE--------REQQNSLTAKVIDLQFQWPPIEKMDSTLGTLVQCERISMSTNMIEK 62
            |:.|.|...||        ||.|...    :.::|....::.|:: |.:.:.......|.|.|..
Human     5 TVTEELTSHEEWSHYNENIREGQKDF----VFVKFNGLHLKSMEN-LQSCISLRVCIFSNNFITD 64

  Fly    63 IFGLSGMKCLKV--LSLSRNYIKQISGLEAVAETLEELWLSYNLIEKIKGLTGLKCLKVLYISNN 125
            |..|  ..|:|:  |.|..|.||.:..        .:.|            .|||.||:||:.:|
Human    65 IHPL--QSCIKLIKLDLHGNQIKSLPN--------TKFW------------NGLKNLKLLYLHDN 107

  Fly   126 LIKDWSEFNRLAEIESLEDLVVVGNPLS--EGLDEPTWRAECIKRLPTIRKLDGEPVVLNEE 185
            ..........|:...:|..|.:...|:|  :|     :|...:..:..::.|| ..|:.:||
Human   108 GFAKLKNICVLSACPTLIALTMFDCPVSLKKG-----YRHVLVNSIWPLKALD-HHVISDEE 163

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8800	NP_610483.1	PPP1R42	37..180	CDD:411060	32/146 (22%)
		leucine-rich repeat	50..71	CDD:275380	5/20 (25%)
		leucine-rich repeat	95..116	CDD:275380	3/20 (15%)
		leucine-rich repeat	117..141	CDD:275380	6/23 (26%)
LRRIQ3	NP_001099129.1	LRR_8	51..109	CDD:290566	21/79 (27%)
		LRR_4	51..89	CDD:289563	12/39 (31%)
		LRR 1	51..72		5/22 (23%)
		leucine-rich repeat	52..73	CDD:275378	6/22 (27%)
		LRR_4	73..115	CDD:289563	15/61 (25%)
		LRR 2	73..94		7/40 (18%)
		leucine-rich repeat	74..98	CDD:275378	8/43 (19%)
		LRR 3	98..119		5/20 (25%)
		leucine-rich repeat	99..123	CDD:275378	6/23 (26%)
		leucine-rich repeat	124..135	CDD:275378	3/10 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0531
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810