DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8800 and CNTRL

DIOPT Version :9

Sequence 1:	NP_610483.1	Gene:	CG8800 / 35962	FlyBaseID:	FBgn0033408	Length:	188	Species:	Drosophila melanogaster
Sequence 2:	XP_011516468.1	Gene:	CNTRL / 11064	HGNCID:	1858	Length:	2340	Species:	Homo sapiens

Alignment Length:	191	Identity:	56/191 - (29%)
Similarity:	98/191 - (51%)	Gaps:	21/191 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IKEALKRWEEREQQNSLTAKVIDL--------QFQWPPIEKMDSTLGTLVQCERISMSTNMIEKI 63
            |.|||.: :..:|.|....|.::|        :|::  ||.::.    .|:.|.:::|.|:|.||
Human    83 ITEALIK-KLTKQDNLALIKSLNLSLSKDGGKKFKY--IENLEK----CVKLEVLNLSYNLIGKI 140

  Fly    64 FGLSGMKCLKVLSLSRNYIKQISGLEAVAETLEELWLSYNLIEKIKGLTG--LKCLKVLYISNNL 126
            ..|..:..|:.|:||.|.|.:|.|:|.:. .|::|.|:.|.||.|....|  ||.|:||.:..|.
Human   141 EKLDKLLKLRELNLSYNKISKIEGIENMC-NLQKLNLAGNEIEHIPVWLGKKLKSLRVLNLKGNK 204

  Fly   127 IKDWSEFNRLAEIESLEDLVVVGNPLSEGLDEPTWRAECIKRLPTIRKLDGEPVVLNEEPQ 187
            |....:.::|..::.|..|::|.||:   :..|.:....|..|.::..|:|:||...:..:
Human   205 ISSLQDISKLKPLQDLISLILVENPV---VTLPHYLQFTIFHLRSLESLEGQPVTTQDRQE 262

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8800	NP_610483.1	PPP1R42	37..180	CDD:411060	45/144 (31%)
		leucine-rich repeat	50..71	CDD:275380	7/20 (35%)
		leucine-rich repeat	95..116	CDD:275380	9/22 (41%)
		leucine-rich repeat	117..141	CDD:275380	6/23 (26%)
CNTRL	XP_011516468.1	leucine-rich repeat	100..119	CDD:275378	3/20 (15%)
		LRR_4	126..167	CDD:289563	15/40 (38%)
		leucine-rich repeat	127..148	CDD:275380	7/20 (35%)
		LRR_8	148..205	CDD:290566	23/57 (40%)
		leucine-rich repeat	149..170	CDD:275380	9/21 (43%)
		LRR_4	169..213	CDD:289563	15/44 (34%)
		leucine-rich repeat	171..194	CDD:275380	9/22 (41%)
		leucine-rich repeat	195..219	CDD:275380	6/23 (26%)
		leucine-rich repeat	220..246	CDD:275380	8/28 (29%)
		SMC_prok_B	<435..1119	CDD:274008
		DUF342	<513..610	CDD:302792
		Pro-rich	<1176..1299	CDD:291893
		COG4372	1320..>1602	CDD:226809
		Mplasa_alph_rch	1525..2221	CDD:275316
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0531
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810