DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myd88 and SIGIRR

DIOPT Version :9

Sequence 1:	NP_001260821.1	Gene:	Myd88 / 35956	FlyBaseID:	FBgn0033402	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	XP_005253101.1	Gene:	SIGIRR / 59307	HGNCID:	30575	Length:	504	Species:	Homo sapiens

Alignment Length:	228	Identity:	54/228 - (23%)
Similarity:	91/228 - (39%)	Gaps:	47/228 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 YNACVLYAEADIDH--ATEIMNNLESERYNLRLFLRHRDML-MGVPFEHVQLSHFMATRCNHLIV 304
            |:|.|.|::...|.  ...|:......|...:|||..||:| ...|...:.::   .:||..|||
Human   165 YDAYVSYSDCPEDRKFVNFILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVN---LSRCRRLIV 226

  Fly   305 VLTEEFLRSP--ENTYLVNFTQKIQIENHTRKIIPILYKTDMHIP-----QTLGIYTHI------ 356
            ||::.||...  .:::.....:.:::   ||:.|.|.::.....|     :.|..:.|:
Human   227 VLSDAFLSRAWCSHSFREGLCRLLEL---TRRPIFITFEGQRRDPAHPALRLLRQHRHLVTLLLW 288

  Fly   357 KYAGDSKLFNFWDKLARSLHDLDAFSIYSTRQVQTPSPVEESAPRVTTPSIRIQINDKDVTDMPN 421
            :....:...:||.::..:|          .|:||. .|||..      |..::| :|||...:..
Human   289 RPGSVTPSSDFWKEVQLAL----------PRKVQY-RPVEGD------PQTQLQ-DDKDPMLILR 335

  Fly   422 YNSCKVPEAETTIVSV----SGDTGSPLPEHKP 450
               .:|||.......|    .||.|.|...|.|
Human   336 ---GRVPEGRALDSEVDPDPEGDLGMPAQPHSP 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myd88	NP_001260821.1	DD	90..172	CDD:301326
Myd88	NP_001260821.1	TIR_2	242..375	CDD:304906	32/147 (22%)
SIGIRR	XP_005253101.1	Ig	8..111	CDD:299845
SIGIRR	XP_005253101.1	TIR	165..311	CDD:279864	34/161 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910