DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myd88 and Tlr5

DIOPT Version :9

Sequence 1:NP_001260821.1 Gene:Myd88 / 35956 FlyBaseID:FBgn0033402 Length:537 Species:Drosophila melanogaster
Sequence 2:XP_017177186.1 Gene:Tlr5 / 53791 MGIID:1858171 Length:873 Species:Mus musculus


Alignment Length:403 Identity:75/403 - (18%)
Similarity:123/403 - (30%) Gaps:154/403 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    74 GLGHFNETPLSALGIETRTQLSRMLNRKKVLRSEEGYQRDWRGISELAKQKGFVDENANNPMDLV 138
            ||.|..|..|.:.|:.     |.:|:        :||   :|.:..||:    :|.:.|....|.
Mouse   132 GLPHLLELRLFSCGLS-----SAVLS--------DGY---FRNLYSLAR----LDLSGNQIHSLR 176

  Fly   139 LISWSQRSPQTAKVGHLEHFLGIIDRWDVCDDIQENLAKDTQRF----IMKQEQRQTALVEACPP 199
            |.|..:.....:.|....:.:     :.:|:|..|.|...|..|    :.|...|.:...|.|..
Mouse   177 LHSSFRELNSLSDVNFAFNQI-----FTICEDELEPLQGKTLSFFGLKLTKLFSRVSVGWETCRN 236

  Fly   200 P-------PSDCFET------NNNYSSSNNITVGQSV----------------QILSDEDQRCVQ 235
            |       ..|..|.      ..|:|   ||..|..:                |.:.|.||... 
Mouse   237 PFRGVRLETLDLSENGWTVDITRNFS---NIIQGSQISSLILKHHIMGPGFGFQNIRDPDQSTF- 297

  Fly   236 MGQPLPRYNACVLYAEADIDH---------------------------------------ATEIM 261
              ..|.|.:...|    |:.|                                       :.:::
Mouse   298 --ASLARSSVLQL----DLSHGFIFSLNPRLFGTLKDLKMLNLAFNKINKIGENAFYGLDSLQVL 356

  Fly   262 N---NLESERYNLRLFLRHRDMLMGVP-FEHVQLSHFMATRCNHLIVVLTEEFLRSPENTYLVNF 322
            |   ||..|.||...:        |:| ..:|.|..      ||:.::..:.|       .|:..
Mouse   357 NLSYNLLGELYNSNFY--------GLPRVAYVDLQR------NHIGIIQDQTF-------RLLKT 400

  Fly   323 TQKIQIENHTRKIIPILYKTDM---------HIPQTLGIYTHIKYAGDSKLFNFWDKLARSLHDL 378
            .|.:.:.::..|.|..:....|         |:|       ||.:..     ||.:.....|.:|
Mouse   401 LQTLDLRDNALKAIGFIPSIQMVLLGGNKLVHLP-------HIHFTA-----NFLELSENRLENL 453

  Fly   379 -DAFSIYSTRQVQ 390
             |.:.:....|:|
Mouse   454 SDLYFLLRVPQLQ 466

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myd88NP_001260821.1 DD 90..172 CDD:301326 15/81 (19%)
TIR_2 242..375 CDD:304906 28/184 (15%)
Tlr5XP_017177186.1 leucine-rich repeat 63..93 CDD:275380
LRR_8 <101..146 CDD:338972 5/13 (38%)
leucine-rich repeat 112..135 CDD:275380 2/2 (100%)
leucine-rich repeat 136..161 CDD:275380 8/40 (20%)
leucine-rich repeat 162..186 CDD:275380 7/27 (26%)
leucine-rich repeat 187..242 CDD:275380 12/59 (20%)
leucine-rich repeat 243..304 CDD:275380 13/66 (20%)
leucine-rich repeat 305..328 CDD:275380 3/26 (12%)
LRR_8 308..363 CDD:338972 5/58 (9%)
leucine-rich repeat 329..352 CDD:275380 0/22 (0%)
LRR_8 352..411 CDD:338972 15/79 (19%)
leucine-rich repeat 353..376 CDD:275380 7/30 (23%)
leucine-rich repeat 377..400 CDD:275380 6/35 (17%)
PRK15370 <397..>597 CDD:185268 16/82 (20%)
leucine-rich repeat 401..429 CDD:275380 4/27 (15%)
leucine-rich repeat 430..464 CDD:275380 9/45 (20%)
leucine-rich repeat 465..489 CDD:275380 1/2 (50%)
leucine-rich repeat 490..518 CDD:275380
leucine-rich repeat 519..542 CDD:275380
leucine-rich repeat 543..561 CDD:275380
leucine-rich repeat 565..585 CDD:275380
PCC 569..>647 CDD:188093
TIR 708..858 CDD:366714
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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