DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myd88 and MYD88

DIOPT Version :9

Sequence 1:	NP_001260821.1	Gene:	Myd88 / 35956	FlyBaseID:	FBgn0033402	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	NP_001166038.2	Gene:	MYD88 / 4615	HGNCID:	7562	Length:	304	Species:	Homo sapiens

Alignment Length:	332	Identity:	83/332 - (25%)
Similarity:	144/332 - (43%)	Gaps:	57/332 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 GSGSGTGTGLGHFNETPLSALGIETRTQLSRMLNRKKVLRSEEGYQRDWRGISELAKQKGFVD-- 128
            |.|:|:...:...:..||:||.:..|.:||..||.:..:.:      ||   :.||::..|..
Human     5 GPGAGSAAPVSSTSSLPLAALNMRVRRRLSLFLNVRTQVAA------DW---TALAEEMDFEYLE 60

  Fly   129 ----ENANNPMDLVLISWSQRSPQTAKVGHLEHFLGIIDRWDVCDDIQENLAKDTQRFIMKQEQR 189
                |...:|...:|.:|..|  ..|.||.|...|..:.|.||..::..::.:|.|::|:||:|.
Human    61 IRQLETQADPTGRLLDAWQGR--PGASVGRLLELLTKLGRDDVLLELGPSIEEDCQKYILKQQQE 123

  Fly   190 ------QTALVEACPPPPSDCFETNNNYSSSNNITVGQSVQILSDEDQRCVQMGQPLPRYNACVL 248
                  |.|.|::..|..::.                ..:..|.|      .:|....|::|.:.
Human   124 EAEKPLQVAAVDSSVPRTAEL----------------AGITTLDD------PLGHMPERFDAFIC 166

  Fly   249 YAEADIDHATEIMNNLESERYNLRLFLRHRDMLMG-----VPFEHVQLSHFMATR----CNHLIV 304
            |..:||....|::..||...|.|:|.:..||:|.|     :..|.::..  :|.|    |..::|
Human   167 YCPSDIQFVQEMIRQLEQTNYRLKLCVSDRDVLPGTCVWSIASELIEKR--LARRPRGGCRRMVV 229

  Fly   305 VLTEEFLRSPENTYLVNFTQKIQIENHTRKIIPILYKT-DMHIPQTLGIYTHIKYAGDSKLFNFW 368
            |:::::|:|.|..:...|...:....|.:::|||.||. ....|..|...|...|........||
Human   230 VVSDDYLQSKECDFQTKFALSLSPGAHQKRLIPIKYKAMKKEFPSILRFITVCDYTNPCTKSWFW 294

  Fly   369 DKLARSL 375
            .:||::|
Human   295 TRLAKAL 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myd88	NP_001260821.1	DD	90..172	CDD:301326	23/87 (26%)
Myd88	NP_001260821.1	TIR_2	242..375	CDD:304906	39/142 (27%)
MYD88	NP_001166038.2	Death_MyD88	29..106	CDD:260026	23/87 (26%)
MYD88	NP_001166038.2	TIR	160..304	CDD:214587	40/144 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159628
Domainoid	1	1.000	50	1.000	Domainoid score	I11744
eggNOG	1	0.900	-	-		E1_28PXY
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	96	1.000	Inparanoid score	I5057
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380911at33208
OrthoFinder	1	1.000	-	-		FOG0006849
OrthoInspector	1	1.000	-	-		oto91631
orthoMCL	1	0.900	-	-		OOG6_108536
Panther	1	1.100	-	-	LDO	PTHR15079
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5112
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.790