Protein Alignment Myd88 and tlr4bb

DIOPT Version :9

• Sequence 1: NP_001260821.1
• Gene: Myd88 / 35956
• FlyBaseID: FBgn0033402
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_997978.2
• Gene: tlr4bb / 403132
• ZFINID: ZDB-GENE-040219-9
• Length: 819
• Species: Danio rerio
• Alignment Length: 409
• Identity: 88/409 - (21%)
• Similarity: 157/409 - (38%)
• Gaps: 119/409 - (29%)

  Fly    45 DVSYRRYRTAGMVVAE----GVMDSGSGSGTGTGLGHF--NETPLSAL-----GIE-------TR 91
            |:||.|.....:...:    .|:.....|.:|..|.:|  |.|.|..|     |||       |.
Zfish   449 DISYTRVHFNTLTFQDLHNLTVLKMAGNSFSGDKLSYFLQNLTSLEVLDISQCGIEKVSMRSFTG 513

  Fly    92 TQLSR--MLNRKKVLRSEEGYQRDWRGISELAKQKGFVDENA--NNPMDLVLISWSQRSPQTAKV 152
            ||..|  .|:|.|::..:...|.:...::.:     ::|:|:  ..|:|::     |:.|..
Zfish   514 TQKLRHLYLSRNKLMVLDFLTQPELTHLTSV-----YIDKNSITTIPLDVL-----QKLPMN--- 565

  Fly   153 GHLEHFLGIIDRWDVCDDIQENLAKDTQRFIMKQEQRQTALVE----ACPPPPSDCFETNNNYSS 213
                     :..:|:..:..:.....|. ||:...|:|..|.:    .|     ..|..|.::.:
Zfish   566 ---------LSEFDLSSNSIDCSCSQTD-FILWIIQKQNILKQLENIRC-----KTFSANTDFKA 615

  Fly   214 ----------SNNITVGQSV---------QILSDEDQRCVQM-----------GQPLPRYNACVL 248
                      ...:|:..||         .||..:....||.           ||....|:|.|:
Zfish   616 IDFDIDYCVHKKRLTIVLSVICVTFVVVLAILLYKFWFYVQYCFILFSGYRSPGQQECSYDAFVI 680

  Fly   249 YAEADIDHA---TEIMNNLESERYNLRLFLRHRDMLMGVPF-EHVQLSHFMATRCNHLIVVLTEE 309
            :  :..|.|   .|:|.|||:....::|.|..||...|... .::.....|.:|  .:|||:::.
Zfish   681 F--SSYDEAWVMNELMENLENGVPPIQLCLHMRDFQAGKSIASNIIDEGIMGSR--KIIVVVSQH 741

  Fly   310 FLRS---------PENTYLVNFTQKIQI-------ENHTRKIIPILYKTDMHIPQTLGIYTHIKY 358
            |:.|         .::.:|:.....|.|       |..|:|:.. |:|   |:.:.    |::|:
Zfish   742 FIDSSWCRFEFELAQSRFLMERNANIIIIILEDVAERKTKKVFG-LHK---HLKKN----TYLKW 798

  Fly   359 AGDSKLFN--FWDKLARSL 375
            :.| .|.|  ||.:|.:::
Zfish   799 SRD-PLSNMRFWIRLRKAI 816

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myd88	NP_001260821.1	DD	90..172	CDD:301326	15/85 (18%)
		TIR_2	242..375	CDD:304906	39/154 (25%)
tlr4bb	NP_997978.2	leucine-rich repeat	56..77	CDD:275380
		LRR_8	77..133	CDD:290566
		leucine-rich repeat	78..101	CDD:275380
		leucine-rich repeat	102..125	CDD:275380
		leucine-rich repeat	126..148	CDD:275380
		leucine-rich repeat	149..173	CDD:275380
		leucine-rich repeat	174..200	CDD:275380
		leucine-rich repeat	201..222	CDD:275380
		LRR_RI	<325..531	CDD:238064	23/81 (28%)
		leucine-rich repeat	326..369	CDD:275380
		leucine-rich repeat	370..395	CDD:275380
		LRR_8	394..455	CDD:290566	3/5 (60%)
		leucine-rich repeat	396..419	CDD:275380
		leucine-rich repeat	420..444	CDD:275380
		LRR_8	443..527	CDD:290566	22/77 (29%)
		leucine-rich repeat	445..467	CDD:275380	4/17 (24%)
		leucine-rich repeat	468..492	CDD:275380	6/23 (26%)
		LRR_8	491..576	CDD:290566	21/106 (20%)
		leucine-rich repeat	493..516	CDD:275380	7/22 (32%)
		leucine-rich repeat	517..540	CDD:275380	5/22 (23%)
		leucine-rich repeat	541..565	CDD:275380	6/33 (18%)
		TIR	675..816	CDD:214587	39/153 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910