DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myd88 and tlr2

DIOPT Version :9

Sequence 1:	NP_001260821.1	Gene:	Myd88 / 35956	FlyBaseID:	FBgn0033402	Length:	537	Species:	Drosophila melanogaster
Sequence 2:	XP_005170910.1	Gene:	tlr2 / 403125	ZFINID:	ZDB-GENE-040219-6	Length:	818	Species:	Danio rerio

Alignment Length:	153	Identity:	36/153 - (23%)
Similarity:	68/153 - (44%)	Gaps:	29/153 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 RYNACVLYAEADIDHATEIM-NNLESERYNLRLFLRHRDM-----LMGVPFEHVQLSHFMATRCN 300
            ||:|.|.|::.|.:...||: ..||..:.:..|.|..||.     ::....:.::.|:
Zfish   671 RYDAFVSYSQHDAEWVEEILVAELEDTQPSFSLCLHKRDFRPGRWIVDNIIDSIEKSY------- 728

  Fly   301 HLIVVLTEEFLRSPENTYLVNFTQ-KIQIENHTRKII----PILYKTDMHIP-------QTLGIY 353
            ..:.||:|.|:.|....|.::|:. :|..|::...::    ||..:|   ||       :.:...
Zfish   729 RTLFVLSEHFVSSEWCRYELDFSHFRIMDEHNDSAVLVLLEPIKKET---IPKRFCKLRKIMNSR 790

  Fly   354 THIKYAGD-SKLFNFWDKLARSL 375
            |::::..| .|...||..|..:|
Zfish   791 TYLEWPEDEDKRDEFWSNLRAAL 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myd88	NP_001260821.1	DD	90..172	CDD:301326
Myd88	NP_001260821.1	TIR_2	242..375	CDD:304906	35/151 (23%)
tlr2	XP_005170910.1	leucine-rich repeat	85..105	CDD:275378
		leucine-rich repeat	106..129	CDD:275378
		LRR_8	108..163	CDD:290566
		leucine-rich repeat	130..153	CDD:275378
		leucine-rich repeat	154..178	CDD:275378
		leucine-rich repeat	179..192	CDD:275378
		LRR_RI	<390..501	CDD:238064
		leucine-rich repeat	390..418	CDD:275380
		LRR_8	418..478	CDD:290566
		leucine-rich repeat	419..444	CDD:275380
		leucine-rich repeat	445..467	CDD:275380
		leucine-rich repeat	468..488	CDD:275380
		leucine-rich repeat	489..508	CDD:275380
		leucine-rich repeat	509..530	CDD:275380
		leucine-rich repeat	531..554	CDD:275380
		TIR	671..814	CDD:214587	36/153 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910